Gene Page: IL8RB

Summary
GeneID  3579
Symbol  IL8RB
Synonyms  CD182|CDw128b|CMKAR2|CXCR2|IL8R2|IL8RA
Description  interleukin 8 receptor, beta
See related  HGNC:6027|MIM:146928|Ensembl:ENSG00000180871|HPRD:00907|
Locus tag  -
Gene type  protein-coding
Map location  2q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0307 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004918interleukin-8 receptor activityIDA10820279 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007200G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)IDA10438939 
GO:0006968cellular defense responseIDA10725748 
GO:0008284positive regulation of cell proliferationIDA10438939 
GO:0006954inflammatory responseTAS9725262 
GO:0006935chemotaxisIDA10725748 
GO:0006915apoptosisIEA-
GO:0042119neutrophil activationIDA10878382 
GO:0030593neutrophil chemotaxisIDA10820279 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIDA10878382 
GO:0009986cell surfaceIDA10878382 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS10438939 
GO:0042629mast cell granuleIDA9725262 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARRB1ARB1 | ARR1arrestin, beta 1-HPRD,BioGRID11170396 
CXCL1FSP | GRO1 | GROa | MGSA | MGSA-a | NAP-3 | SCYB1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)-HPRD1379593 |8550564 
|8702798 |8940121 
in vivoBioGRID1379593 |8702798 
|8940121 
CXCL2CINC-2a | GRO2 | GROb | MGSA-b | MIP-2a | MIP2 | MIP2A | SCYB2chemokine (C-X-C motif) ligand 2-HPRD,BioGRID8702798 |9260277 
CXCL3CINC-2b | GRO3 | GROg | MIP-2b | MIP2B | SCYB3chemokine (C-X-C motif) ligand 3-HPRD,BioGRID8702798 
CXCL5ENA-78 | SCYB5chemokine (C-X-C motif) ligand 5-HPRD,BioGRID8702798 |9692902 
CXCL6CKA-3 | GCP-2 | GCP2 | SCYB6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)-HPRD,BioGRID9692902 |10593335 
GNA15GNA16guanine nucleotide binding protein (G protein), alpha 15 (Gq class)-HPRD,BioGRID9843397 
GTF3AAP2 | TFIIIAgeneral transcription factor IIIAAffinity Capture-WesternBioGRID11170396 
IL8CXCL8 | GCP-1 | GCP1 | LECT | LUCT | LYNAP | MDNCF | MONAP | NAF | NAP-1 | NAP1interleukin 8-HPRD,BioGRID8702798 |9464567 
IL8RBCD182 | CDw128b | CMKAR2 | CXCR2 | IL8R2 | IL8RAinterleukin 8 receptor, beta-HPRD,BioGRID12888558 
MYO5BKIAA1119myosin VBAffinity Capture-WesternBioGRID15004234 
PPBPB-TG1 | Beta-TG | CTAP-III | CTAP3 | CTAPIII | CXCL7 | LA-PF4 | LDGF | MDGF | NAP-2 | PBP | SCYB7 | TC1 | TC2 | TGB | TGB1 | THBGB | THBGB1pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)-HPRD,BioGRID8195702 |8702798 
RAB11FIP2KIAA0941 | Rab11-FIP2 | nRip11RAB11 family interacting protein 2 (class I)-HPRD,BioGRID15004234 
RGS12DKFZp761K1617 | DKFZp761K1817regulator of G-protein signaling 12-HPRD9651375 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 6844All SZGR genes in this pathway
ST_GRANULE_CELL_SURVIVAL_PATHWAY 2723All SZGR genes in this pathway
PID_IL8_CXCR2_PATHWAY 3426All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES 5727All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
LIAN_LIPA_TARGETS_6M 7447All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN 148102All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
LIAN_LIPA_TARGETS_3M 5936All SZGR genes in this pathway
YOKOE_CANCER_TESTIS_ANTIGENS 3822All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
MARTINELLI_IMMATURE_NEUTROPHIL_DN 139All SZGR genes in this pathway
MIZUKAMI_HYPOXIA_UP 1212All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS 4430All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS_AND_CYCLIC_RGD 2115All SZGR genes in this pathway
ZWANG_EGF_INTERVAL_DN 214124All SZGR genes in this pathway


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