Gene Page: IL12B

Summary
GeneID  3593
Symbol  IL12B
Synonyms  CLMF|CLMF2|IL-12B|NKSF|NKSF2
Description  interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
See related  HGNC:5970|MIM:161561|Ensembl:ENSG00000113302|HPRD:01194|
Locus tag  -
Gene type  protein-coding
Map location  5q31.1-q33.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS9789052 
GO:0005125cytokine activityIDA1674604 
GO:0004896cytokine receptor activityIEA-
GO:0005143interleukin-12 receptor bindingTAS1674604 
GO:0005515protein bindingIPI10899108 
GO:0042164interleukin-12 alpha subunit bindingIEA-
GO:0042803protein homodimerization activityIEA-
GO:0046982protein heterodimerization activityIPI1674604 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetIDA7903063 
GO:0007166cell surface receptor linked signal transductionIEA-
GO:0007050cell cycle arrestIDA16942485 
GO:0010224response to UV-BIDA8992506 
GO:0042093T-helper cell differentiationIDA1673147 
GO:0032816positive regulation of natural killer cell activationIDA1674604 
GO:0016477cell migrationIDA7903063 
GO:0042104positive regulation of activated T cell proliferationIDA1674604 
GO:0032729positive regulation of interferon-gamma productionIDA1674604 
GO:0042088T-helper 1 type immune responseTAS1673147 
GO:0034393positive regulation of smooth muscle cell apoptosisIDA16942485 
GO:0042035regulation of cytokine biosynthetic processTAS1673147 
GO:0045785positive regulation of cell adhesionIDA7903063 
GO:0045078positive regulation of interferon-gamma biosynthetic processTAS1673147 
GO:0048662negative regulation of smooth muscle cell proliferationIDA16942485 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0016020membraneIEA-
GO:0043514interleukin-12 complexIDA1674604 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
IL12ACLMF | IL-12A | NFSK | NKSF1 | P35interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)-HPRD,BioGRID10899108 
IL12BCLMF | CLMF2 | IL-12B | NKSF | NKSF2interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)p40 interacts with p40 and forms a homodimer.BIND7527811 
IL12RB1CD212 | IL-12R-BETA1 | IL12RB | MGC34454interleukin 12 receptor, beta 1-HPRD7527811 |7843232 
IL12RB2-interleukin 12 receptor, beta 2-HPRD11940489 
IL23AIL-23 | IL-23A | IL23P19 | MGC79388 | P19 | SGRFinterleukin 23, alpha subunit p19Affinity Capture-WesternBioGRID11114383 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 10288All SZGR genes in this pathway
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 7151All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
KEGG_TYPE_I_DIABETES_MELLITUS 4438All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_ALLOGRAFT_REJECTION 3834All SZGR genes in this pathway
BIOCARTA_CYTOKINE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_INFLAM_PATHWAY 2924All SZGR genes in this pathway
BIOCARTA_DC_PATHWAY 2220All SZGR genes in this pathway
BIOCARTA_IL12_PATHWAY 2317All SZGR genes in this pathway
BIOCARTA_NO2IL12_PATHWAY 1714All SZGR genes in this pathway
BIOCARTA_NKT_PATHWAY 2921All SZGR genes in this pathway
BIOCARTA_TH1TH2_PATHWAY 1914All SZGR genes in this pathway
PID_IL27_PATHWAY 2620All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_IL23_PATHWAY 3730All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
LIU_TARGETS_OF_VMYB_VS_CMYB_DN 4330All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
GAURNIER_PSMD4_TARGETS 7355All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_UP 5241All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_A 6752All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
BUDHU_LIVER_CANCER_METASTASIS_DN 77All SZGR genes in this pathway
WORSCHECH_TUMOR_EVASION_AND_TOLEROGENICITY_UP 3019All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1533623681Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-4483623681Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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