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GeneID |
3593
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Symbol |
IL12B
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Synonyms |
CLMF|CLMF2|IL-12B|NKSF|NKSF2
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Description |
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) |
See related |
HGNC:5970|MIM:161561|Ensembl:ENSG00000113302|HPRD:01194| |
Locus tag |
- |
Gene type |
protein-coding |
Map location |
5q31.1-q33.1 |
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Gene set name |
Method of gene set |
Evidence |
Info |
Association | A combined odds ratio method (Sun et al. 2008), association studies | 1 | Link to SZGene | GSMA_I | genome scan meta-analysis | Psr: 0.0032 | | GSMA_IIE | genome scan meta-analysis (European-ancestry samples) | Psr: 0.01718 | | GSMA_IIA | genome scan meta-analysis (All samples) | Psr: 0.00459 | | Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia] | Click to show detail |
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General Gene Expression (microarray) ? |
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Gene Expression in Brain Regions (new) |
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Top co-expressed genes in Brain Regions (new) |
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Gene | Pearson's Correlation | Spearman's Correlation | | |
Top 10 positively co-expressed genes |
Top 10 negatively co-expressed genes | |
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0004871 | signal transducer activity | TAS | | 9789052 |
GO:0005125 | cytokine activity | IDA | | 1674604 |
GO:0004896 | cytokine receptor activity | IEA | | - |
GO:0005143 | interleukin-12 receptor binding | TAS | | 1674604 |
GO:0005515 | protein binding | IPI | | 10899108 |
GO:0042164 | interleukin-12 alpha subunit binding | IEA | | - |
GO:0042803 | protein homodimerization activity | IEA | | - |
GO:0046982 | protein heterodimerization activity | IPI | | 1674604 |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0002860 | positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | IDA | | 7903063 |
GO:0007166 | cell surface receptor linked signal transduction | IEA | | - |
GO:0007050 | cell cycle arrest | IDA | | 16942485 |
GO:0010224 | response to UV-B | IDA | | 8992506 |
GO:0042093 | T-helper cell differentiation | IDA | | 1673147 |
GO:0032816 | positive regulation of natural killer cell activation | IDA | | 1674604 |
GO:0016477 | cell migration | IDA | | 7903063 |
GO:0042104 | positive regulation of activated T cell proliferation | IDA | | 1674604 |
GO:0032729 | positive regulation of interferon-gamma production | IDA | | 1674604 |
GO:0042088 | T-helper 1 type immune response | TAS | | 1673147 |
GO:0034393 | positive regulation of smooth muscle cell apoptosis | IDA | | 16942485 |
GO:0042035 | regulation of cytokine biosynthetic process | TAS | | 1673147 |
GO:0045785 | positive regulation of cell adhesion | IDA | | 7903063 |
GO:0045078 | positive regulation of interferon-gamma biosynthetic process | TAS | | 1673147 |
GO:0048662 | negative regulation of smooth muscle cell proliferation | IDA | | 16942485 |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0005576 | extracellular region | IEA | | - |
GO:0016020 | membrane | IEA | | - |
GO:0043514 | interleukin-12 complex | IDA | | 1674604 |
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- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.
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