Gene Page: ITGA5

Summary
GeneID  3678
Symbol  ITGA5
Synonyms  CD49e|FNRA|VLA5A
Description  integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
See related  HGNC:6141|MIM:135620|Ensembl:ENSG00000161638|HPRD:00627|
Locus tag  -
Gene type  protein-coding
Map location  12q11-q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0066 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RAB8A0.920.92
GANAB0.910.91
HEATR60.910.94
NAT100.910.94
DET10.910.92
GEMIN50.910.94
TH1L0.910.94
RPN20.910.90
RNPEP0.910.93
DDB10.910.92
Top 10 negatively co-expressed genes
MT-CO2-0.77-0.87
AF347015.31-0.77-0.86
AF347015.27-0.74-0.84
FXYD1-0.73-0.83
IFI27-0.73-0.84
AF347015.33-0.73-0.82
AF347015.8-0.72-0.84
AF347015.21-0.72-0.88
MT-CYB-0.72-0.82
CXCL14-0.70-0.81
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0005178integrin bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionTAS2454952 
GO:0007157heterophilic cell adhesionIEA-
GO:0007229integrin-mediated signaling pathwayIEA-
GO:0007613memoryIEA-
GO:0007044cell-substrate junction assemblyIEA-
GO:0007159leukocyte adhesionIEA-
GO:0033631cell-cell adhesion mediated by integrinIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0001726ruffleTAS11919189 
GO:0005794Golgi apparatusIDA18029348 
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIDA18029348 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0009897external side of plasma membraneIEA-
GO:0008305integrin complexTAS2454952 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANGPTL3ANGPT5angiopoietin-like 3-HPRD11877390 
ARHGAP5GFI2 | RhoGAP5 | p190-BRho GTPase activating protein 5-HPRD8537347 
AUP1-ancient ubiquitous protein 1-HPRD,BioGRID12042322 
CD95H9 | BA2 | BTCC-1 | DRAP-27 | GIG2 | MIC3 | MRP-1 | P24 | TSPAN29CD9 molecule-HPRD,BioGRID10065872 
COL18A1FLJ27325 | FLJ34914 | KNO | KNO1 | MGC74745collagen, type XVIII, alpha 1-HPRD11158588 
COL1A1OI4collagen, type I, alpha 1-HPRD1693626 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD10888683 
F2PTcoagulation factor II (thrombin)-HPRD9864377 
FN1CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSFfibronectin 1Reconstituted ComplexBioGRID1532572 
-HPRD9211865 |11801679 
GIPC1C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2GIPC PDZ domain containing family, member 1-HPRD,BioGRID11479315 
ILKDKFZp686F1765 | P59integrin-linked kinaseAffinity Capture-WesternBioGRID8538749 
ITGB1CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLABintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)VLA5-alpha5 interacts with VLA5-beta.BIND1690718 |1693624 
|3546305 
ITGB5FLJ26658integrin, beta 5-HPRD7592829|11462216 
L1CAMCAML1 | CD171 | HSAS | HSAS1 | MASA | MIC5 | N-CAML1 | S10 | SPG1L1 cell adhesion molecule-HPRD,BioGRID10871287 
NISCHFLJ14425 | FLJ40413 | FLJ90519 | I-1 | IRAS | KIAA0975nischarin-HPRD12868002 |15028619 
PECAM1CD31 | PECAM-1platelet/endothelial cell adhesion molecule-HPRD10982404 
SPP1BNSP | BSPI | ETA-1 | MGC110940 | OPNsecreted phosphoprotein 1-HPRD,BioGRID7592829 
TNCHXB | MGC167029 | TNtenascin C-HPRD9314546 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ECM_RECEPTOR_INTERACTION 8453All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 7659All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY 9268All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
PID_INTEGRIN1_PATHWAY 6644All SZGR genes in this pathway
PID_INTEGRIN_CS_PATHWAY 2616All SZGR genes in this pathway
PID_ARF6_TRAFFICKING_PATHWAY 4934All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_SYNDECAN_4_PATHWAY 3225All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY 4230All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY 3327All SZGR genes in this pathway
PID_LYMPH_ANGIOGENESIS_PATHWAY 2516All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 9165All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
REACTOME_SIGNAL_TRANSDUCTION_BY_L1 3425All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_UP 8858All SZGR genes in this pathway
LA_MEN1_TARGETS 2415All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_HELA 164118All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_240_MCF10A 5736All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_UP 157105All SZGR genes in this pathway
GALINDO_IMMUNE_RESPONSE_TO_ENTEROTOXIN 8567All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_UP 14083All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN 162102All SZGR genes in this pathway
CHIARETTI_ACUTE_LYMPHOBLASTIC_LEUKEMIA_ZAP70 6733All SZGR genes in this pathway
PETROVA_PROX1_TARGETS_DN 6438All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_RESPONSE 3528All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_UP 5635All SZGR genes in this pathway
ZHANG_PROLIFERATING_VS_QUIESCENT 5141All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C5 2111All SZGR genes in this pathway
BURTON_ADIPOGENESIS_2 7252All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 3926All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_8HR 3931All SZGR genes in this pathway
GHO_ATF5_TARGETS_DN 1610All SZGR genes in this pathway
ITO_PTTG1_TARGETS_DN 97All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_DN 5839All SZGR genes in this pathway
HUANG_DASATINIB_RESISTANCE_UP 8153All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
GU_PDEF_TARGETS_UP 7149All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_D 6844All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP 221150All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G2 2717All SZGR genes in this pathway
YAMANAKA_GLIOBLASTOMA_SURVIVAL_UP 117All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
QI_HYPOXIA_TARGETS_OF_HIF1A_AND_FOXA2 3727All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
PEDERSEN_TARGETS_OF_611CTF_ISOFORM_OF_ERBB2 7645All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_PROGENITOR_DN 149All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1281891961A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-148/1529029091A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-25/32/92/363/3679899961A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-261341411A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-271901971A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-5p2052121A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-314054111Ahsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-3264094151Ahsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-328141147m8hsa-miR-328brainCUGGCCCUCUCUGCCCUUCCGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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