Gene Page: ITGAX

Summary
GeneID  3687
Symbol  ITGAX
Synonyms  CD11C|SLEB6
Description  integrin, alpha X (complement component 3 receptor 4 subunit)
See related  HGNC:6152|MIM:151510|Ensembl:ENSG00000140678|HPRD:01051|
Locus tag  -
Gene type  protein-coding
Map location  16p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PYCR20.780.73
SIDT20.780.71
PIGV0.770.73
TMEM1290.770.75
TMEM2140.760.68
SLC6A80.750.71
FICD0.740.71
SLC41A10.740.74
SLC44A20.740.75
RECQL50.730.68
Top 10 negatively co-expressed genes
FAM159B-0.45-0.48
AF347015.21-0.41-0.19
AC087071.1-0.40-0.28
AL050337.1-0.38-0.25
RP9P-0.38-0.36
SPDYA-0.35-0.25
NOX1-0.34-0.25
RPL13AP22-0.34-0.43
SYCP3-0.34-0.22
DDTL-0.34-0.24
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000287magnesium ion bindingIEA-
GO:0004872receptor activityIEA-
GO:0004872receptor activityTAS2303426 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionIEA-
GO:0007155cell adhesionTAS2303426 
GO:0007229integrin-mediated signaling pathwayIEA-
GO:0009887organ morphogenesisTAS3327687 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0009897external side of plasma membraneIEA-
GO:0008305integrin complexTAS2303426 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C3ARMD9 | ASP | CPAMD1complement component 3-HPRD7512600 
Reconstituted ComplexBioGRID4062888 
FCER2CD23 | CD23A | CLEC4J | FCE2 | IGEBFFc fragment of IgE, low affinity II, receptor for (CD23)-HPRD7621072 
ITGB2CD18 | LAD | LCAMB | LFA-1 | MAC-1 | MF17 | MFI7integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)-HPRD,BioGRID11937543 
JAM3FLJ14529 | JAM-C | JAMCjunctional adhesion molecule 3-HPRD,BioGRID12208882 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
BIOCARTA_DC_PATHWAY 2220All SZGR genes in this pathway
PID_INTEGRIN_CS_PATHWAY 2616All SZGR genes in this pathway
PID_INTEGRIN2_PATHWAY 2918All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 9165All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
APPIERTO_RESPONSE_TO_FENRETINIDE_UP 3826All SZGR genes in this pathway
AMUNDSON_RESPONSE_TO_ARSENITE 217143All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
GOLUB_ALL_VS_AML_DN 2414All SZGR genes in this pathway
ROSS_AML_WITH_MLL_FUSIONS 7845All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS 191131All SZGR genes in this pathway
STEARMAN_TUMOR_FIELD_EFFECT_UP 3622All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN 6139All SZGR genes in this pathway
PODAR_RESPONSE_TO_ADAPHOSTIN_UP 14798All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_D 6844All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway


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