Gene Page: JUN

Summary
GeneID  3725
Symbol  JUN
Synonyms  AP-1|AP1|c-Jun
Description  jun oncogene
See related  HGNC:6204|MIM:165160|Ensembl:ENSG00000177606|HPRD:01302|
Locus tag  -
Gene type  protein-coding
Map location  1p32-p31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02692 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZDHHC140.800.83
KCNC40.790.82
LENG40.790.82
GPR610.790.84
RAPGEFL10.780.82
P2RX50.770.82
GALNTL40.760.82
C19orf280.760.76
NDRG40.760.83
SLC7A40.760.83
Top 10 negatively co-expressed genes
UXT-0.41-0.42
SNRPG-0.41-0.52
RPL24-0.40-0.44
RPL35A-0.40-0.49
RBMX2-0.39-0.45
RPS20-0.39-0.52
RPS6-0.39-0.45
RPS16P1-0.39-0.50
RPL37-0.39-0.53
RPS25P8-0.39-0.48
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS2825349 |10973489 
GO:0003702RNA polymerase II transcription factor activityTAS9443941 
GO:0043565sequence-specific DNA bindingIEA-
GO:0046983protein dimerization activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0009987cellular processIEA-
GO:0035026leading edge cell differentiationIEA-
GO:0031953negative regulation of protein amino acid autophosphorylationIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0051726regulation of cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000228nuclear chromosomeTAS10918580 
GO:0005829cytosolEXP9030721 
GO:0005634nucleusIEA-
GO:0005667transcription factor complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID8798722 |9211894 
ASCC1ASC1p50 | CGI-18 | RP11-150D20.4activating signal cointegrator 1 complex subunit 1Reconstituted Complex
Two-hybrid
BioGRID12077347 
ASCC2ASC1p100activating signal cointegrator 1 complex subunit 2Reconstituted Complex
Two-hybrid
BioGRID12077347 
ASCC3ASC1p200 | DJ467N11.1 | HELIC1 | MGC26074 | RNAH | dJ121G13.4activating signal cointegrator 1 complex subunit 3Reconstituted Complex
Two-hybrid
BioGRID12077347 
ATF1EWS-ATF1 | FUS/ATF-1 | TREB36activating transcription factor 1-HPRD,BioGRID8570175 
ATF2CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7activating transcription factor 2Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
BioGRID1827203 |2320002 
|8027667 
-HPRD1827203 |2320002 
|9445037 
ATF3-activating transcription factor 3-HPRD8649793 |14667575 
Affinity Capture-WesternBioGRID8622660 |14667575 
ATF4CREB-2 | CREB2 | TAXREB67 | TXREBactivating transcription factor 4 (tax-responsive enhancer element B67)-HPRD,BioGRID1827203 
BATFB-ATF | BATF1 | SFA-2basic leucine zipper transcription factor, ATF-like-HPRD,BioGRID8570175 
BCL3BCL4 | D19S37B-cell CLL/lymphoma 3-HPRD,BioGRID10497212 
BCL6BCL5 | BCL6A | LAZ3 | ZBTB27 | ZNF51B-cell CLL/lymphoma 6-HPRD,BioGRID12165517 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetBRCA1 interacts with c-Jun.BIND12080089 
-HPRD,BioGRID12080089 
BTG1-B-cell translocation gene 1, anti-proliferativeBTG1 interacts with JUN (c-Jun). This interaction was modeled on a demonstrated interaction between human BTG1 and quail c-Jun.BIND15674337 
COBRA1DKFZp586B0519 | KIAA1182 | NELF-B | NELFBcofactor of BRCA1-HPRD,BioGRID15530430 
COPS5CSN5 | JAB1 | MGC3149 | MOV-34 | SGN5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)-HPRD,BioGRID8837781 
CREB5CRE-BPAcAMP responsive element binding protein 5-HPRD,BioGRID8440710 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID2138276 |9786917 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD,BioGRID9685505 
CSNK2A2CK2A2 | CSNK2A1 | FLJ43934casein kinase 2, alpha prime polypeptideFar Western
Reconstituted Complex
BioGRID9685505 
CYP19A1ARO | ARO1 | CPV1 | CYAR | CYP19 | MGC104309 | P-450AROMcytochrome P450, family 19, subfamily A, polypeptide 1JUN (cJUN) interacts with the CYP19A1 (aromatase PII) promoter.BIND15688015 
DDIT3CEBPZ | CHOP | CHOP10 | GADD153 | MGC4154DNA-damage-inducible transcript 3-HPRD,BioGRID10523647 
DDX21DKFZp686F21172 | GUA | GURDB | RH-II/GU | RH-II/GuADEAD (Asp-Glu-Ala-Asp) box polypeptide 21-HPRD,BioGRID11823437 
DHX9DDX9 | LKP | NDHII | RHADEAH (Asp-Glu-Ala-His) box polypeptide 9-HPRD,BioGRID11823437 
EGR1AT225 | G0S30 | KROX-24 | NGFI-A | TIS8 | ZIF-268 | ZNF225early growth response 1-HPRD11278640 
ERGerg-3 | p55v-ets erythroblastosis virus E26 oncogene homolog (avian)-HPRD,BioGRID11278640 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1ER-alpha interacts with c-Jun. This interaction was modeled on a demonstrated interaction between human ER-alpha, and mouse c-Jun.BIND11477071 
-HPRD,BioGRID11477071 
ETS1ETS-1 | EWSR2 | FLJ10768v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)-HPRD,BioGRID8557686 
ETS2ETS2IT1v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)-HPRD,BioGRID9334186 
FBXW7AGO | CDC4 | DKFZp686F23254 | FBW6 | FBW7 | FBX30 | FBXO30 | FBXW6 | FLJ16457 | SEL-10 | SEL10F-box and WD repeat domain containing 7Fbw7-beta interacts with c-Jun.BIND16023596 
Fbw7-alpha interacts with c-Jun.BIND16023596 
Fbw7-gamma interacts with c-Jun.BIND16023596 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homologc-Jun interacts with c-Fos. This interaction was modelled on a demonstrated interaction between c-Jun from an unspecified species and c-Fos from an unspecified species.BIND10488148 
Co-crystal Structure
Reconstituted Complex
Two-hybrid
BioGRID7816143 |8380166 
|8440710 |9160889 
|9872330 |10488148 
|11053448 
cFos interacts with cJun.BIND8816797 |8816798 
-HPRD1631061 |7816143 
|9346889 
FOSL1FRA | FRA1 | fra-1FOS-like antigen 1c-Jun interacts with the region of the FRA-1 promoter containing the TRE, SRE and ATF sites.BIND15806162 
-HPRD11708771 |11912197 
Reconstituted Complex
Two-hybrid
BioGRID9160889 
FOSL2FLJ23306 | FRA2FOS-like antigen 2Two-hybridBioGRID9160889 
-HPRD11708771 
GATA2MGC2306 | NFE1BGATA binding protein 2-HPRD,BioGRID11278891 
GTF2BTF2B | TFIIBgeneral transcription factor IIBReconstituted ComplexBioGRID7848298 
GTF2E2FE | TF2E2 | TFIIE-Bgeneral transcription factor IIE, polypeptide 2, beta 34kDaReconstituted ComplexBioGRID8628277 
GTF2F1BTF4 | RAP74 | TF2F1 | TFIIFgeneral transcription factor IIF, polypeptide 1, 74kDaReconstituted ComplexBioGRID8628277 
GTF2F2BTF4 | RAP30 | TF2F2 | TFIIFgeneral transcription factor IIF, polypeptide 2, 30kDa-HPRD,BioGRID8628277 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3-HPRD,BioGRID12853483 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)-HPRD,BioGRID11739718 
HMGA1HMG-R | HMGA1A | HMGIY | MGC12816 | MGC4242 | MGC4854high mobility group AT-hook 1-HPRD,BioGRID10357819 
HNRNPMDKFZp547H118 | HNRNPM4 | HNRPM | HNRPM4 | HTGR1 | NAGR1heterogeneous nuclear ribonucleoprotein M-HPRD,BioGRID11823437 
JAG1AGS | AHD | AWS | CD339 | HJ1 | JAGL1 | MGC104644jagged 1 (Alagille syndrome)c-Jun interacts with Jagged1 promoter.BIND16023595 
JDP2JUNDM2Jun dimerization protein 2-HPRD9154808 
JUNAP-1 | AP1 | c-Junjun oncogeneReconstituted Complex
Two-hybrid
BioGRID7848298 |8440710 
|10488148 
-HPRD1631061 
c-Jun interacts with another molecule of c-Jun.BIND15706351 
cJun interacts with a second cJun molecule.BIND8816797 
c-Jun interacts with c-Jun. This interaction was modelled on a demonstrated interaction between c-Jun from an unspecified species and c-Jun from an unspecified species.BIND10488148 
JUNBAP-1jun B proto-oncogenec-Jun interacts with Jun B.BIND15240010 
KHSRPFBP2 | FUBP2 | KSRP | MGC99676KH-type splicing regulatory proteinKSRP interacts with AREjun. This interaction was modeled on a demonstrated interaction between KSRP from human and AREjun from an unspecified species.BIND15175153 
MAFMGC71685 | c-MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)-HPRD8108109 
MAPK10FLJ12099 | FLJ33785 | JNK3 | JNK3A | MGC50974 | PRKM10 | p493F12 | p54bSAPKmitogen-activated protein kinase 10MAPK10 (JNK3) phosphorylates JUN (c-Jun)BIND16007099 
JNK3alpha2 interacts with c-Jun.BIND12167088 
JNK3alpha1 interacts with c-Jun.BIND12167088 
MAPK11P38B | P38BETA2 | PRKM11 | SAPK2 | SAPK2B | p38-2 | p38Betamitogen-activated protein kinase 11p38-2 interacts with and very weakly phosphorylates c-Jun.BIND9235954 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14An unspecified isoform of p38 interacts with and phosphorylates c-Jun.BIND9155018 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3-HPRD,BioGRID1922387 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8-HPRD,BioGRID8137421 
JNK1 phosphorylates c-Jun. This interaction was modeled on a demonstrated interaction between bovine JNK1 or JNK1 from an unspecified species, and c-Jun from an unspecified species.BIND9374537 
JNK1beta2 interacts with c-Jun.BIND12167088 
c-Jun is phosphorylated by JNK-1. This interaction was modeled on a demonstrated interaction between c-Jun and JNK-1, both from an unspecified species.BIND9020136 
JNK1beta1 interacts with c-Jun.BIND12167088 
JNK1alpha1 interacts with c-Jun.BIND12167088 
MAPK8 (JNK1) phosphorylates JUN (c-Jun)BIND16007099 
JNK1alpha2 interacts with c-Jun.BIND12167088 
MAPK9JNK-55 | JNK2 | JNK2A | JNK2ALPHA | JNK2B | JNK2BETA | PRKM9 | SAPK | p54a | p54aSAPKmitogen-activated protein kinase 9JNK2beta2 interacts with c-Jun.BIND12167088 
JNK2alpha2 interacts with c-Jun.BIND12167088 
Biochemical ActivityBioGRID8945519 
JNK2beta1 interacts with c-Jun.BIND12167088 
JNK2alpha1 interacts with c-Jun.BIND12167088 
An unspecified isoform of JNK2 interacts with and phosphorylates c-Jun.BIND9155018 
MAPKAPK5PRAKmitogen-activated protein kinase-activated protein kinase 5-HPRD9628874 
MYBBP1AFLJ37886 | P160 | PAP2MYB binding protein (P160) 1a-HPRD8302594 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1-HPRD,BioGRID1310896 
NACAHSD48 | MGC117224 | NACA1nascent polypeptide-associated complex alpha subunit-HPRD,BioGRID9488446 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1-HPRD,BioGRID9642216 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6Reconstituted ComplexBioGRID10847592 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2Reconstituted Complex
Two-hybrid
BioGRID10777532 
NFE2L1FLJ00380 | LCR-F1 | NRF1 | TCF11nuclear factor (erythroid-derived 2)-like 1-HPRD,BioGRID9872330 
NFE2L2NRF2nuclear factor (erythroid-derived 2)-like 2Affinity Capture-Western
Reconstituted Complex
BioGRID9872330 
NFYACBF-A | CBF-B | FLJ11236 | HAP2 | NF-YAnuclear transcription factor Y, alphaAffinity Capture-WesternBioGRID11903046 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)-HPRD7823959 |8733011 
Reconstituted ComplexBioGRID14522952 
NR5A1AD4BP | ELP | FTZ1 | FTZF1 | SF-1 | SF1nuclear receptor subfamily 5, group A, member 1-HPRD,BioGRID10478848 
NRIP1FLJ77253 | RIP140nuclear receptor interacting protein 1-HPRD,BioGRID12554755 
PACS1FLJ10209 | KIAA1175phosphofurin acidic cluster sorting protein 1-HPRD11331585 
PHOX2AARIX | CFEOM2 | FEOM2 | MGC52227 | NCAM2 | PMX2Apaired-like homeobox 2aReconstituted ComplexBioGRID14506227 
PIAS1DDXBP1 | GBP | GU/RH-II | MGC141878 | MGC141879 | ZMIZ3protein inhibitor of activated STAT, 1-HPRD11867732 
PIN1DOD | UBL5peptidylprolyl cis/trans isomerase, NIMA-interacting 1-HPRD,BioGRID11432833 
PLEKHO1CKIP-1 | OC120pleckstrin homology domain containing, family O member 1CKIP-1 interacts with c-Jun.BIND15706351 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD,BioGRID9671405 
POU1F1GHF-1 | PIT1 | Pit-1POU class 1 homeobox 1-HPRD,BioGRID8663380 
PPP4CPP4 | PPH3 | PPXprotein phosphatase 4 (formerly X), catalytic subunitReconstituted ComplexBioGRID9837938 
PRKD1PKC-MU | PKCM | PKD | PRKCMprotein kinase D1-HPRD,BioGRID11948398 
RAGEMOK | RAGE1renal tumor antigen-HPRD,BioGRID10421840 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD,BioGRID10026157 
RB interacts with c-Jun.BIND10026157 
RBM39CAPER | CAPERalpha | CC1.3 | DKFZp781C0423 | FLJ44170 | HCC1 | RNPC2 | fSAP59RNA binding motif protein 39-HPRD,BioGRID11704680 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)NF-kappa-B interacts with c-Jun.BIND10488148 
-HPRD,BioGRID9468519 |10488148 
RFWD2COP1 | FLJ10416 | RNF200ring finger and WD repeat domain 2-HPRD,BioGRID12615916 
The carboxy-terminal WD-40 repeat region of hCOP1 interacts with c-jun.BIND14739464 
RPL18A-ribosomal protein L18a-HPRD7662174 
RUNX1AML1 | AML1-EVI-1 | AMLCR1 | CBFA2 | EVI-1 | PEBP2aBrunt-related transcription factor 1-HPRD,BioGRID11274169 
RUNX2AML3 | CBFA1 | CCD | CCD1 | MGC120022 | MGC120023 | OSF2 | PEA2aA | PEBP2A1 | PEBP2A2 | PEBP2aA | PEBP2aA1runt-related transcription factor 2-HPRD,BioGRID11274169 |11641401 
SARSFLJ36399 | SERRS | SERSseryl-tRNA synthetaseAffinity Capture-WesternBioGRID11331419 
SKISKVv-ski sarcoma viral oncogene homolog (avian)-HPRD,BioGRID12034730 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID10220381 |11371641 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD,BioGRID9732876 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD10220381 
SMARCD1BAF60A | CRACD1 | Rsc6pSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1-HPRD11053448 
SNRKDKFZp779A1866 | FLJ20224 | HSNFRK | KIAA0096SNF related kinase-HPRD10878360 |12087103 
SP1-Sp1 transcription factor-HPRD,BioGRID10506225 
SPI1OF | PU.1 | SFPI1 | SPI-1 | SPI-Aspleen focus forming virus (SFFV) proviral integration oncogene spi1Reconstituted ComplexBioGRID9681824 
-HPRD12091339 
SPIBSPI-BSpi-B transcription factor (Spi-1/PU.1 related)-HPRD,BioGRID10196196 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD,BioGRID10490649 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID10490649 
STAT4SLEB11signal transducer and activator of transcription 4-HPRD,BioGRID11801649 
TAF1BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa-HPRD,BioGRID11316804 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding protein-HPRD,BioGRID7848298 
TCF20AR1 | KIAA0292 | SPBPtranscription factor 20 (AR1)-HPRD,BioGRID8663478 
TGIF1HPE4 | MGC39747 | MGC5066 | TGIFTGFB-induced factor homeobox 1-HPRD,BioGRID11371641 
TOP2ATOP2 | TP2Atopoisomerase (DNA) II alpha 170kDa-HPRD,BioGRID8387155 
TPM2AMCD1 | DA1 | DA2B | TMSBtropomyosin 2 (beta)-HPRD1631061 
TRIP4HsT17391thyroid hormone receptor interactor 4-HPRD12077347 
TSC22D3DIP | DKFZp313A1123 | DSIPI | GILZ | TSC-22R | hDIPTSC22 domain family, member 3-HPRD,BioGRID11397794 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)-HPRD,BioGRID8733011 
VAV1VAVvav 1 guanine nucleotide exchange factorBiochemical ActivityBioGRID11287617 
VDRNR1I1vitamin D (1,25- dihydroxyvitamin D3) receptor-HPRD,BioGRID10330159 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptideJNK interacts with 14-3-3-eta.BIND15696159 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1393773841A,m8hsa-miR-139brainUCUACAGUGCACGUGUCU
miR-141/200a620626m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-25/32/92/363/3673673731Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-30-3p7037091Ahsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-3627177231Ahsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
miR-493-5p515521m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-495596602m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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