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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: KCNA1

Summary

GeneID

3736

Symbol

KCNA1

Synonyms

AEMK|EA1|HBK1|HUK1|KV1.1|MBK1|MGC126782|MGC138385|MK1|RBK1

Description

potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)

Locus tag

Gene type

protein-coding

Map location

12p13.32

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

CHRM1

0.93

0.90

C2orf55

0.90

0.79

ADAMTS8

0.89

0.77

ARHGEF4

0.88

0.82

AC105206.1

0.87

0.86

KCNH3

0.87

0.82

DGKZ

0.87

0.83

CACNG3

0.87

0.90

PDE2A

0.86

0.87

GRIN1

0.86

0.79

Top 10 negatively co-expressed genes

HEBP2

-0.53

-0.64

BCL7C

-0.48

-0.52

C21orf57

-0.44

-0.41

C9orf46

-0.44

-0.40

RBMX2

-0.44

-0.41

EXOSC8

-0.44

-0.33

DYNLT1

-0.44

-0.45

FAM36A

-0.42

-0.34

RPL23A

-0.42

-0.39

UBE2L6

-0.42

-0.24

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IEA

GO:0005244

voltage-gated ion channel activity

IEA

GO:0005249

voltage-gated potassium channel activity

IEA

GO:0005251

delayed rectifier potassium channel activity

TAS

8845167

GO:0015079

potassium ion transmembrane transporter activity

TAS

8845167

GO:0030955

potassium ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007268

synaptic transmission

TAS

neuron, Synap, Neurotransmitter (GO term level: 6)

7842011

GO:0006811

ion transport

IEA

GO:0006813

potassium ion transport

IEA

GO:0006813

potassium ion transport

TAS

8845167

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016020

membrane

IEA

GO:0016021

integral to membrane

IEA

GO:0008076

voltage-gated potassium channel complex

IEA

GO:0008076

voltage-gated potassium channel complex

TAS

8845167

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CNTNAP1	CASPR \| CNTNAP \| NRXN4 \| P190	contactin associated protein 1	Affinity Capture-Western	BioGRID	14592966
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	Reconstituted Complex Two-hybrid	BioGRID	12435606
KCNA2	HBK5 \| HK4 \| HUKIV \| KV1.2 \| MGC50217 \| MK2 \| NGK1 \| RBK2	potassium voltage-gated channel, shaker-related subfamily, member 2	Affinity Capture-Western	BioGRID	10428084
KCNA3	HGK5 \| HLK3 \| HPCN3 \| HUKIII \| KV1.3 \| MK3 \| PCN3	potassium voltage-gated channel, shaker-related subfamily, member 3	Affinity Capture-Western	BioGRID	10428084
KCNA4	HBK4 \| HK1 \| HPCN2 \| HUKII \| KCNA4L \| KCNA8 \| KV1.4 \| PCN2	potassium voltage-gated channel, shaker-related subfamily, member 4	Affinity Capture-Western	BioGRID	10428084
KCNAB2	AKR6A5 \| HKvbeta2 \| HKvbeta2.1 \| HKvbeta2.2 \| KCNA2B \| KV-BETA-2 \| MGC117289	potassium voltage-gated channel, shaker-related subfamily, beta member 2	-	HPRD	12893943
KCNE4	MGC20353 \| MIRP3	potassium voltage-gated channel, Isk-related family, member 4	-	HPRD	12944270
RTN4	ASY \| NI220/250 \| NOGO \| NOGO-A \| NOGOC \| NSP \| NSP-CL \| Nbla00271 \| Nbla10545 \| Nogo-B \| Nogo-C \| RTN-X \| RTN4-A \| RTN4-B1 \| RTN4-B2 \| RTN4-C	reticulon 4	Affinity Capture-Western	BioGRID	14592966

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
REACTOME_NEURONAL_SYSTEM	279	221	All SZGR genes in this pathway
REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	43	32	All SZGR genes in this pathway
REACTOME_POTASSIUM_CHANNELS	98	68	All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_DN	139	76	All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN	260	143	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK	1442	892	All SZGR genes in this pathway
SCHLESINGER_H3K27ME3_IN_NORMAL_AND_METHYLATED_IN_CANCER	28	21	All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS	1038	678	All SZGR genes in this pathway
BENPORATH_EED_TARGETS	1062	725	All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3	1118	744	All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS	652	441	All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_UP	89	59	All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_UP	81	52	All SZGR genes in this pathway
LIN_NPAS4_TARGETS_DN	68	48	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	349	234	All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE	721	492	All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3	210	148	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	1080	713	All SZGR genes in this pathway
GOBERT_CORE_OLIGODENDROCYTE_DIFFERENTIATION	40	28	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	4461	4467	1A	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	4461	4467	1A	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-101	1033	1040	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-124/506	1651	1657	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1651	1657	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-125/351	1273	1280	1A,m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	1273	1280	1A,m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-128	4588	4594	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
				hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-133	1316	1322	1A	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	1316	1322	1A	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-137	2897	2903	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-144	1034	1040	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-153	5303	5310	1A,m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-155	1108	1114	m8	hsa-miR-155	UUAAUGCUAAUCGUGAUAGGGG
miR-18	596	603	1A,m8	hsa-miR-18a	UAAGGUGCAUCUAGUGCAGAUA
miR-18	596	603	1A,m8	hsa-miR-18b	UAAGGUGCAUCUAGUGCAGUUA
miR-182	4269	4275	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-186	1403	1409	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-21	929	935	m8	hsa-miR-21^brain	UAGCUUAUCAGACUGAUGUUGA
miR-21	929	935	m8	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
miR-218	839	845	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-221/222	3184	3190	1A	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	3184	3190	1A	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-25/32/92/363/367	1467	1474	1A,m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-27	1791	1797	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1791	1797	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-323	3231	3237	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-34/449	4267	4273	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-342	1793	1799	1A	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-34b	3277	3284	1A,m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-363	4592	4598	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-409-5p	4227	4234	1A,m8	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-448	5304	5310	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-452	4593	4599	m8	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC
miR-500	1465	1472	1A,m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-542-3p	5323	5329	m8	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-7	3448	3454	1A	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-9	3573	3580	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/520	3265	3271	1A	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU
miR-96	4269	4275	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.