Gene Page: KCNA2

Summary
GeneID  3737
Symbol  KCNA2
Synonyms  HBK5|HK4|HUKIV|KV1.2|MGC50217|MK2|NGK1|RBK2
Description  potassium voltage-gated channel, shaker-related subfamily, member 2
See related  HGNC:6220|MIM:176262|Ensembl:ENSG00000177301|HPRD:01443|
Locus tag  -
Gene type  protein-coding
Map location  1p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
ExpressionExpressionP value: 1.879 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GALNTL60.750.61
HSD11B20.720.30
ZAP700.720.29
OTX20.720.34
RGS190.710.53
EGFL60.700.44
ANO20.690.52
MAP4K10.690.30
EPHA10.680.31
RAB3B0.680.63
Top 10 negatively co-expressed genes
AF347015.27-0.28-0.49
AF347015.33-0.27-0.48
MT-CO2-0.27-0.49
AIF1L-0.27-0.41
AF347015.31-0.27-0.47
MT-CYB-0.26-0.48
PTGDS-0.26-0.36
S100A1-0.26-0.41
AF347015.2-0.26-0.50
AF347015.8-0.26-0.48
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005244voltage-gated ion channel activityIEA-
GO:0005249voltage-gated potassium channel activityIEA-
GO:0005251delayed rectifier potassium channel activityTAS1715584 
GO:0030955potassium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006811ion transportIEA-
GO:0006813potassium ion transportIEA-
GO:0006813potassium ion transportTAS2251283 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0008076voltage-gated potassium channel complexIEA-
GO:0008076voltage-gated potassium channel complexTAS2251283 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CNTNAP1CASPR | CNTNAP | NRXN4 | P190contactin associated protein 1Affinity Capture-WesternBioGRID14592966 
CTTNEMS1 | FLJ34459cortactin-HPRD,BioGRID12151401 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID8938729 |12435606 
KCNA1AEMK | EA1 | HBK1 | HUK1 | KV1.1 | MBK1 | MGC126782 | MGC138385 | MK1 | RBK1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)Affinity Capture-WesternBioGRID10428084 
KCNA3HGK5 | HLK3 | HPCN3 | HUKIII | KV1.3 | MK3 | PCN3potassium voltage-gated channel, shaker-related subfamily, member 3-HPRD12944270 
Affinity Capture-WesternBioGRID10428084 
KCNA4HBK4 | HK1 | HPCN2 | HUKII | KCNA4L | KCNA8 | KV1.4 | PCN2potassium voltage-gated channel, shaker-related subfamily, member 4Affinity Capture-WesternBioGRID10428084 
KCNA5ATFB7 | HCK1 | HK2 | HPCN1 | KV1.5 | MGC117058 | MGC117059 | PCN1potassium voltage-gated channel, shaker-related subfamily, member 5Affinity Capture-WesternBioGRID12815189 
KCNAB1AKR6A3 | KCNA1B | KV-BETA-1 | Kvb1.3 | hKvBeta3 | hKvb3potassium voltage-gated channel, shaker-related subfamily, beta member 1-HPRD,BioGRID8636142 |11401852 
KCNAB2AKR6A5 | HKvbeta2 | HKvbeta2.1 | HKvbeta2.2 | KCNA2B | KV-BETA-2 | MGC117289potassium voltage-gated channel, shaker-related subfamily, beta member 2-HPRD,BioGRID8636142 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD,BioGRID11739373 
PTPRAHEPTP | HLPR | HPTPA | HPTPalpha | LRP | PTPA | PTPRL2 | R-PTP-alpha | RPTPAprotein tyrosine phosphatase, receptor type, AAffinity Capture-Western
Reconstituted Complex		BioGRID9878055 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member AAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9635436 
RTN4ASY | NI220/250 | NOGO | NOGO-A | NOGOC | NSP | NSP-CL | Nbla00271 | Nbla10545 | Nogo-B | Nogo-C | RTN-X | RTN4-A | RTN4-B1 | RTN4-B2 | RTN4-Creticulon 4Affinity Capture-WesternBioGRID14592966 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1371091161A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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