Gene Page: KCNJ2

Summary
GeneID  3759
Symbol  KCNJ2
Synonyms  HHBIRK1|HHIRK1|IRK1|KIR2.1|LQT7|SQT3
Description  potassium inwardly-rectifying channel, subfamily J, member 2
See related  HGNC:6263|MIM:600681|Ensembl:ENSG00000123700|HPRD:02815|
Locus tag  -
Gene type  protein-coding
Map location  17q23.1-q24.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0018 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
THAP40.570.54
ATF50.570.57
PFKL0.560.60
FTSJ20.560.55
RCCD10.560.60
POFUT20.560.59
ABCD10.560.59
C19orf610.550.58
TRAF20.550.58
STARD30.550.56
Top 10 negatively co-expressed genes
AF347015.31-0.47-0.51
MT-CO2-0.46-0.51
AF347015.27-0.44-0.49
AF347015.21-0.43-0.48
MT-CYB-0.43-0.49
AF347015.33-0.43-0.47
AF347015.8-0.42-0.48
AF347015.2-0.39-0.46
AF347015.15-0.39-0.45
MYL3-0.39-0.43
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11287423 |12923176 
GO:0005242inward rectifier potassium channel activityTAS7696590 
GO:0005244voltage-gated ion channel activityIEA-
GO:0030955potassium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006811ion transportIEA-
GO:0006813potassium ion transportTAS7696590 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS7696590 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKAP5AKAP75 | AKAP79 | H21A kinase (PRKA) anchor protein 5-HPRD11287423 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD,BioGRID11181181 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID10627592 
IL16FLJ16806 | FLJ42735 | FLJ44234 | HsT19289 | IL-16 | LCF | prIL-16interleukin 16 (lymphocyte chemoattractant factor)-HPRD,BioGRID10479680 
KCNJ16BIR9 | KIR5.1 | MGC33717potassium inwardly-rectifying channel, subfamily J, member 16-HPRD11240146 
KCNJ8KIR6.1 | uKATP-1potassium inwardly-rectifying channel, subfamily J, member 8-HPRD10559219 
TRAK2ALS2CR3 | CALS-C | GRIF-1 | GRIF1 | KIAA0549 | OIP98trafficking protein, kinesin binding 2Affinity Capture-Western
Two-hybrid		BioGRID16895905 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS 2517All SZGR genes in this pathway
REACTOME_GABA_B_RECEPTOR_ACTIVATION 3826All SZGR genes in this pathway
REACTOME_GABA_RECEPTOR_ACTIVATION 5240All SZGR genes in this pathway
REACTOME_POTASSIUM_CHANNELS 9868All SZGR genes in this pathway
REACTOME_INWARDLY_RECTIFYING_K_CHANNELS 3120All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON 335181All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_UP 183111All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_4HR 3722All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_DN 5334All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1 9175All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_DN 10864All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MIKKELSEN_MCV6_ICP_WITH_H3K4ME3_AND_H3K27ME3 3421All SZGR genes in this pathway
MIKKELSEN_MEF_ICP_WITH_H3K4ME3_AND_H3K27ME3 3834All SZGR genes in this pathway
MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3 12683All SZGR genes in this pathway
UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN 3726All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3 13785All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.13663731A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5063663721Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-132/21226752681m8hsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-135146814741Ahsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-141/200a455461m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/497216021671A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-1825185241Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-197327391A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-1935455521A,m8hsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-200bc/42914471453m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-21935723578m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-26314431511A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-320272527311Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-410366536711Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-431357363m8hsa-miR-431UGUCUUGCAGGCCGUCAUGCA
hsa-miR-431UGUCUUGCAGGCCGUCAUGCA
miR-4552032101A,m8hsa-miR-455UAUGUGCCUUUGGACUACAUCG
miR-49524142420m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-496250425101Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-503216121671Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
hsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-5054574641A,m8hsa-miR-505GUCAACACUUGCUGGUUUCCUC
miR-736233629m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
miR-97137201A,m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-965185241Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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