Gene Page: KCNJ6

Summary
GeneID  3763
Symbol  KCNJ6
Synonyms  BIR1|GIRK2|KATP2|KCNJ7|KIR3.2|MGC126596|hiGIRK2
Description  potassium inwardly-rectifying channel, subfamily J, member 6
See related  HGNC:6267|MIM:600877|Ensembl:ENSG00000157542|HPRD:02929|
Locus tag  -
Gene type  protein-coding
Map location  21q22.1|21q22.13-q22.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4758 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SLC12A50.900.91
CNNM10.870.87
PRRT30.860.87
NPTN0.860.88
DIRAS20.860.89
SLC35F30.860.88
HTR5A0.850.88
BMPER0.850.80
MFSD40.850.77
NLK0.850.83
Top 10 negatively co-expressed genes
RAB13-0.42-0.48
GTF3C6-0.42-0.36
RBMX2-0.42-0.41
PDE9A-0.41-0.35
GPR125-0.41-0.32
SNHG12-0.40-0.44
CDC42EP4-0.40-0.37
BCL7C-0.39-0.44
FAM36A-0.39-0.32
EXOSC8-0.39-0.28
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005244voltage-gated ion channel activityIEA-
GO:0015467G-protein activated inward rectifier potassium channel activityTAS7550338 
GO:0030955potassium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006811ion transportIEA-
GO:0006813potassium ion transportTAS7796919 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIDA16780588 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIDA16780588 
GO:0008076voltage-gated potassium channel complexTAS7796919 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRB2ADRB2R | ADRBR | B2AR | BAR | BETA2ARadrenergic, beta-2-, receptor, surface-HPRD12297500 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)Reconstituted ComplexBioGRID10619846 
DRD2D2DR | D2Rdopamine receptor D2-HPRD,BioGRID12297500 
KCNJ3GIRK1 | KGA | KIR3.1potassium inwardly-rectifying channel, subfamily J, member 3-HPRD8929423 |9023358 
KCNJ9GIRK3 | KIR3.3potassium inwardly-rectifying channel, subfamily J, member 9-HPRD,BioGRID10956667 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS 2517All SZGR genes in this pathway
REACTOME_GABA_B_RECEPTOR_ACTIVATION 3826All SZGR genes in this pathway
REACTOME_GABA_RECEPTOR_ACTIVATION 5240All SZGR genes in this pathway
REACTOME_POTASSIUM_CHANNELS 9868All SZGR genes in this pathway
REACTOME_INWARDLY_RECTIFYING_K_CHANNELS 3120All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
ROPERO_HDAC2_TARGETS 11471All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
ONDER_CDH1_SIGNALING_VIA_CTNNB1 8358All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway


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