Gene Page: KCNN3

Summary
GeneID  3782
Symbol  KCNN3
Synonyms  KCa2.3|SK3|SKCA3|hSK3
Description  potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
See related  HGNC:6292|MIM:602983|Ensembl:ENSG00000143603|HPRD:04283|
Locus tag  -
Gene type  protein-coding
Map location  1q21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005516calmodulin bindingIEA-
GO:0005216ion channel activityIEA-
GO:0016286small conductance calcium-activated potassium channel activityIEA-
GO:0015269calcium-activated potassium channel activityIEA-
GO:0015269calcium-activated potassium channel activityTAS8781233 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)8781233 
GO:0007399nervous system developmentTASneurite (GO term level: 5)9491810 
GO:0006813potassium ion transportIEA-
GO:0006813potassium ion transportTAS8781233 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0008076voltage-gated potassium channel complexTAS8781233 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_POTASSIUM_CHANNELS 9868All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP 201125All SZGR genes in this pathway
DAVICIONI_PAX_FOXO1_SIGNATURE_IN_ARMS_UP 5938All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
BASSO_CD40_SIGNALING_DN 6844All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_UP 9864All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
YOSHIOKA_LIVER_CANCER_EARLY_RECURRENCE_UP 4023All SZGR genes in this pathway
MIKKELSEN_MEF_ICP_WITH_H3K27ME3 206108All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_HP_DN 4723All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3 13785All SZGR genes in this pathway
WIEDERSCHAIN_TARGETS_OF_BMI1_AND_PCGF2 5739All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_2HR_DN 5535All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_UP 16697All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-12212181Ahsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-150206212m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-1552127m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-1855561m8hsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-20835411Ahsa-miR-208AUAAGACGAGCAAAAAGCUUGU
miR-49935411Ahsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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