Gene Page: KDR

Summary
GeneID  3791
Symbol  KDR
Synonyms  CD309|FLK1|VEGFR|VEGFR2
Description  kinase insert domain receptor (a type III receptor tyrosine kinase)
See related  HGNC:6307|MIM:191306|Ensembl:ENSG00000128052|HPRD:01867|
Locus tag  -
Gene type  protein-coding
Map location  4q11-q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.148 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005021vascular endothelial growth factor receptor activityTAS1417831 
GO:0004872receptor activityIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
GO:0019838growth factor bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001570vasculogenesisIEA-
GO:0001525angiogenesisIEA-
GO:0001541ovarian follicle developmentIEA-
GO:0002053positive regulation of mesenchymal cell proliferationIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0008360regulation of cell shapeIDA7929439 
GO:0048469cell maturationIEA-
GO:0048010vascular endothelial growth factor receptor signaling pathwayIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0050927positive regulation of positive chemotaxisIDA7929439 
GO:0048754branching morphogenesis of a tubeIEA-
GO:0048286alveolus developmentIEA-
GO:0030335positive regulation of cell migrationIDA7929439 
GO:0043129surfactant homeostasisIEA-
GO:0030097hemopoiesisIEA-
GO:0045165cell fate commitmentIEA-
GO:0050679positive regulation of epithelial cell proliferationIEA-
GO:0044419interspecies interaction between organismsIEA-
GO:0045446endothelial cell differentiationIEA-
GO:0055074calcium ion homeostasisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS1656371 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACP1HAAP | MGC111030 | MGC3499acid phosphatase 1, soluble-HPRD,BioGRID10608891 
ANXA5ANX5 | ENX2 | PP4annexin A5-HPRD,BioGRID10329451 
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)Affinity Capture-WesternBioGRID11950700 
-HPRD10428027 
COL18A1FLJ27325 | FLJ34914 | KNO | KNO1 | MGC74745collagen, type XVIII, alpha 1-HPRD,BioGRID12029087 
FIGFVEGF-D | VEGFDc-fos induced growth factor (vascular endothelial growth factor D)-HPRD,BioGRID9435229 
FLT1FLT | VEGFR1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)-HPRD10865839 
Biochemical ActivityBioGRID12796773 
GRB10GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSSgrowth factor receptor-bound protein 10-HPRD,BioGRID11494124 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID10319320 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1Reconstituted ComplexBioGRID9398617 
PLCG2-phospholipase C, gamma 2 (phosphatidylinositol-specific)-HPRD9398617 
PLXNA1NOV | NOVP | PLEXIN-A1 | PLXN1plexin A1Affinity Capture-WesternBioGRID14977921 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1Affinity Capture-WesternBioGRID10319320 
SHBRP11-3J10.8 | bA3J10.2Src homology 2 domain containing adaptor protein B-HPRD,BioGRID15026417 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Affinity Capture-WesternBioGRID10319320 |11950700 
-HPRD10749680 
SHC2SCK | SHCB | SLISHC (Src homology 2 domain containing) transforming protein 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID10749680 
Sck interacts with KDR.BIND10749680 
VEGFAMGC70609 | VEGF | VEGF-A | VPFvascular endothelial growth factor AVEGF-A interacts with VEGFR-2. This interaction was modeled on a demonstrated interaction between human VEGF-A and VEGFR-2 from an unspecified species.BIND12810700 
VEGF165 interacts with KDR. This interaction was modeled on a demonstrated interaction between human VEGF165 and KDR from an unspecified species.BIND14600159 
-HPRD8621427 
VEGF interacts with KDR.BIND15542434 
Biochemical ActivityBioGRID12716911 
VEGFCFlt4-L | VRPvascular endothelial growth factor C-HPRD11332691 
VEGF-C interacts with VEGFR-2. This interaction was modeled on a demonstrated interaction between human VEGF-C and VEGFR-2 from an unspecified species.BIND12810700 
 


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