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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: KPNA3

Summary

GeneID

3839

Symbol

KPNA3

Synonyms

IPOA4|SRP1gamma|SRP4|hSRP1

Description

karyopherin alpha 3 (importin alpha 4)

Locus tag

RP11-432M24.3

Gene type

protein-coding

Map location

13q14.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Association

A combined odds ratio method (Sun et al. 2008), association studies

Link to SZGene

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005488

binding

IEA

GO:0005515

protein binding

IPI

15057270 |17353931 |17981117

GO:0008565

protein transporter activity

IEA

GO:0008139

nuclear localization sequence binding

TAS

9435235

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006461

protein complex assembly

TAS

9435235

GO:0006607

NLS-bearing substrate import into nucleus

TAS

9435235

GO:0006886

intracellular protein transport

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IEA

GO:0005643

nuclear pore

TAS

9154134

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARRB1	ARB1 \| ARR1	arrestin, beta 1	Affinity Capture-MS	BioGRID	17353931
ARRB2	ARB2 \| ARR2 \| BARR2 \| DKFZp686L0365	arrestin, beta 2	Affinity Capture-MS	BioGRID	17353931
FAM50B	D6S2654E \| X5L	family with sequence similarity 50, member B	Two-hybrid	BioGRID	16189514
HNRNPC	C1 \| C2 \| HNRNP \| HNRPC \| MGC104306 \| MGC105117 \| MGC117353 \| MGC131677 \| SNRPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	Two-hybrid	BioGRID	16189514
KPNB1	IMB1 \| IPOB \| Impnb \| MGC2155 \| MGC2156 \| MGC2157 \| NTF97	karyopherin (importin) beta 1	Reconstituted Complex	BioGRID	9435235 \|10523667
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Affinity Capture-MS	BioGRID	14743216
RCC1	CHC1 \| RCC1-I	regulator of chromosome condensation 1	-	HPRD,BioGRID	10744690

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES	66	45	All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING	159	116	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM	270	204	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP	404	246	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN	770	415	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	483	336	All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN	514	319	All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS	988	594	All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS	734	436	All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS	775	494	All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_COPY_NUMBER_DN	31	21	All SZGR genes in this pathway
BYSTROEM_CORRELATED_WITH_IL5_DN	64	47	All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_DN	245	154	All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP	88	64	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED	1022	619	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED	1229	713	All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN	409	268	All SZGR genes in this pathway
LIN_MELANOMA_COPY_NUMBER_DN	41	34	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP	973	570	All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1	91	75	All SZGR genes in this pathway
GRADE_COLON_CANCER_UP	871	505	All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP	285	167	All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP	294	199	All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN	185	116	All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP	518	299	All SZGR genes in this pathway
DANG_BOUND_BY_MYC	1103	714	All SZGR genes in this pathway
LU_EZH2_TARGETS_DN	414	237	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN	918	550	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE	317	190	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	1045	1051	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-103/107	2303	2309	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	2303	2309	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-124/506	1844	1850	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1844	1850	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	1512	1518	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	1512	1518	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-134	141	147	m8	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-135	130	136	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	130	136	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-138	1114	1120	1A	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-141/200a	2327	2333	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	2327	2333	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-144	1045	1051	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-15/16/195/424/497	2459	2465	1A	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d	2307	2313	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
				hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-182	155	162	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-186	1854	1860	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-188	1462	1469	1A,m8	hsa-miR-188	CAUCCCUUGCAUGGUGGAGGGU
miR-19	2100	2107	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	2100	2107	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-208	1057	1063	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-214	757	763	m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-223	524	531	1A,m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-23	1457	1463	1A	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	1457	1463	1A	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-24	428	434	m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-26	821	827	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	821	827	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	1512	1518	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1512	1518	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	1041	1047	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-323	1096	1102	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-324-3p	1270	1276	1A	hsa-miR-324-3p	CCACUGCCCCAGGUGCUGCUGG
miR-33	1447	1453	m8	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	1447	1453	m8	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-381	1657	1663	m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-381	1657	1663	m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-409-5p	1079	1085	1A	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-409-5p	1079	1085	1A	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-431	370	376	1A	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA
miR-448	190	196	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-455	1817	1823	1A	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG
miR-499	1056	1063	1A,m8	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-500	414	420	m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-503	2459	2465	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-539	1779	1785	m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-542-3p	1399	1406	1A,m8	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-96	156	162	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.