Gene Page: LHX1

Summary
GeneID  3975
Symbol  LHX1
Synonyms  LIM-1|LIM1|MGC126723|MGC138141
Description  LIM homeobox 1
See related  HGNC:6593|MIM:601999|Ensembl:ENSG00000132130|HPRD:09067|
Locus tag  -
Gene type  protein-coding
Map location  17q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ARAP10.830.83
LTBP30.800.81
LZTS20.770.77
PLXNB10.760.75
RNPEPL10.760.75
DNM20.750.72
SLC38A100.750.72
TLN10.740.74
PLOD30.730.76
TMEM1040.730.71
Top 10 negatively co-expressed genes
C18orf32-0.39-0.47
LY96-0.38-0.26
GLMN-0.37-0.39
CLEC2B-0.37-0.19
SYCP3-0.37-0.25
NOX1-0.37-0.29
AC087071.1-0.37-0.21
CAPZA2-0.36-0.40
TMEM126A-0.36-0.38
AL050337.1-0.36-0.25
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityNAS9212161 
GO:0003702RNA polymerase II transcription factor activityTAS9212161 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0021702cerebellar Purkinje cell differentiationIEAneuron, GABA, Brain (GO term level: 15)-
GO:0021549cerebellum developmentIEABrain (GO term level: 10)-
GO:0007399nervous system developmentTASneurite (GO term level: 5)9212161 
GO:0001706endoderm formationIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0009887organ morphogenesisTAS7700351 
GO:0009791post-embryonic developmentIEA-
GO:0030154cell differentiationIEA-
GO:0021937Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FOXA2HNF3B | MGC19807 | TCF3Bforkhead box A2Reconstituted ComplexBioGRID12642491 
LHX3DKFZp762A2013 | LIM3 | M2-LHX3LIM homeobox 3Reconstituted ComplexBioGRID9452425 
OTX2MCOPS5 | MGC45000orthodenticle homeobox 2Reconstituted ComplexBioGRID10623575 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
TANAKA_METHYLATED_IN_ESOPHAGEAL_CARCINOMA 10358All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN 5142All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS 7441All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 5034All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
LEIN_CEREBELLUM_MARKERS 8547All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
MATZUK_IMPLANTATION_AND_UTERINE 2215All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K27ME3 269159All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway


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