Gene Page: LRP2

Summary
GeneID  4036
Symbol  LRP2
Synonyms  DBS|gp330
Description  low density lipoprotein-related protein 2
See related  HGNC:6694|MIM:600073|Ensembl:ENSG00000081479|HPRD:02509|
Locus tag  -
Gene type  protein-coding
Map location  2q24-q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02395 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.3965 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RUNDC3A0.870.88
HAGH0.860.88
RHBDD20.860.88
PGP0.840.87
FKBP80.840.88
ABHD80.830.87
NBL10.830.81
RAB260.830.81
PEF10.830.82
STUB10.820.88
Top 10 negatively co-expressed genes
EIF5B-0.58-0.68
THOC2-0.54-0.52
AC005921.3-0.52-0.74
CCAR1-0.51-0.48
ZNF326-0.51-0.51
UPF3B-0.50-0.53
SFRS12-0.50-0.48
RBM25-0.49-0.50
MAP4K4-0.48-0.46
SFRS18-0.48-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0005529sugar bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI9773776 |14528014 
GO:0017124SH3 domain bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0006486protein amino acid glycosylationTAS2786251 
GO:0008283cell proliferationIEA-
GO:0006766vitamin metabolic processIEA-
GO:0006629lipid metabolic processTAS7768901 
GO:0006898receptor-mediated endocytosisTAS7768901 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIEA-
GO:0005624membrane fractionIEA-
GO:0005764lysosomeTAS7768901 
GO:0005768endosomeIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005905coated pitIEA-
GO:0005903brush borderIEA-
GO:0016324apical plasma membraneIEA-
GO:0030139endocytic vesicleIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ALBDKFZp779N1935 | PRO0883 | PRO0903 | PRO1341albumin-HPRD8898021|11158855 
ANAPC10APC10 | DKFZp564L0562 | DOC1anaphase promoting complex subunit 10Two-hybridBioGRID10827173 
ANKRA2ANKRAankyrin repeat, family A (RFXANK-like), 2-HPRD,BioGRID11095640 
ANKS1BAIDA | AIDA-1 | ANKS2 | EB-1 | MGC26087 | cajalin-2ankyrin repeat and sterile alpha motif domain containing 1B-HPRD,BioGRID12508107 
APBA2D15S1518E | HsT16821 | LIN-10 | MGC99508 | MGC:14091 | MINT2 | X11Lamyloid beta (A4) precursor protein-binding, family A, member 2Two-hybridBioGRID10827173 
APBB1FE65 | MGC:9072 | RIRamyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)-HPRD9837937 
APOBFLDBapolipoprotein B (including Ag(x) antigen)-HPRD10330424 
APOEAD2 | LPG | MGC1571 | apoproteinapolipoprotein E-HPRD11421580 
Reconstituted ComplexBioGRID7768901 
APOHB2G1 | BGapolipoprotein H (beta-2-glycoprotein I)-HPRD,BioGRID9727058 
CLUAAG4 | APOJ | CLI | KUB1 | MGC24903 | SGP-2 | SGP2 | SP-40 | TRPM-2 | TRPM2clusterin-HPRD,BioGRID7768901 
CUBNFLJ90055 | FLJ90747 | IFCR | MGA1 | gp280cubilin (intrinsic factor-cobalamin receptor)-HPRD11595644|11994745 
DAB1-disabled homolog 1 (Drosophila)-HPRD,BioGRID10827173 
DAB2DOC-2 | DOC2 | FLJ26626disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)-HPRD,BioGRID10769163 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD12713445 
DLG2DKFZp781D1854 | DKFZp781E0954 | FLJ37266 | MGC131811 | PSD-93discs, large homolog 2, chapsyn-110 (Drosophila)-HPRD,BioGRID12713445 
DLG3KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102discs, large homolog 3 (neuroendocrine-dlg, Drosophila)-HPRD,BioGRID12713445 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID12713445 
GCDBP | DBP/GC | VDBG | VDBPgroup-specific component (vitamin D binding protein)-HPRD,BioGRID11717447 
GIPC1C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2GIPC PDZ domain containing family, member 1-HPRD,BioGRID11912251 
GPRASP1GASP | GASP1 | KIAA0443G protein-coupled receptor associated sorting protein 1-HPRD11274227 
INSILPR | IRDNinsulin-HPRD9773776 
ITGB1BP1DKFZp686K08158 | ICAP-1A | ICAP-1B | ICAP-1alpha | ICAP1 | ICAP1A | ICAP1Bintegrin beta 1 binding protein 1-HPRD,BioGRID10827173 
LDLRAP1ARH | ARH1 | ARH2 | DKFZp586D0624 | FHCB1 | FHCB2 | MGC34705low density lipoprotein receptor adaptor protein 1-HPRD,BioGRID14528014 
LPAAK38 | APOA | LPlipoprotein, Lp(a)-HPRD,BioGRID10073957 
LPLHDLCQ11 | LIPDlipoprotein lipase-HPRD,BioGRID7686151 
LRP2BPDKFZp761O0113 | FLJ44965LRP2 binding protein-HPRD,BioGRID12508107 
LRPAP1A2MRAP | A2RAP | HBP44 | MGC138272 | MRAP | RAPlow density lipoprotein receptor-related protein associated protein 1-HPRD,BioGRID7512726 
MAGI1AIP3 | BAIAP1 | BAP1 | MAGI-1 | TNRC19 | WWP3membrane associated guanylate kinase, WW and PDZ domain containing 1-HPRD,BioGRID11274227 
MAPK8IP1IB1 | JIP-1 | JIP1 | PRKM8IPmitogen-activated protein kinase 8 interacting protein 1-HPRD,BioGRID10827173 
MAPK8IP2IB2 | JIP2 | PRKM8IPLmitogen-activated protein kinase 8 interacting protein 2Reconstituted Complex
Two-hybrid		BioGRID10827173 |12508107 
MDKFLJ27379 | MK | NEGF2midkine (neurite growth-promoting factor 2)-HPRD10772929 
NOS1AP6330408P19Rik | CAPON | MGC138500nitric oxide synthase 1 (neuronal) adaptor protein-HPRD,BioGRID10827173 
PLAUATF | UPA | URK | UROKINASE | u-PAplasminogen activator, urokinase-HPRD,BioGRID8344937 
RBP1CRABP-I | CRBP | CRBP1 | CRBPI | RBPCretinol binding protein 1, cellular-HPRD,BioGRID10203351 
SCGB1A1CC10 | CC16 | CCSP | UGBsecretoglobin, family 1A, member 1 (uteroglobin)-HPRD,BioGRID11278724 
SCN3AKIAA1356 | NAC3 | Nav1.3sodium channel, voltage-gated, type III, alpha subunitTwo-hybridBioGRID10827173 
SERPINE1PAI | PAI-1 | PAI1 | PLANH1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1-HPRD8344937 
SLC9A3MGC126718 | MGC126720 | NHE3solute carrier family 9 (sodium/hydrogen exchanger), member 3-HPRD10364184 
SNX17KIAA0064sorting nexin 17Reconstituted ComplexBioGRID12169628 
SYNJ2BPARIP2 | FLJ11271 | FLJ41973 | OMP25synaptojanin 2 binding protein-HPRD,BioGRID10827173 
TGAITD3 | TGNthyroglobulin-HPRD9492085 
THBS1THBS | TSP | TSP1thrombospondin 1Reconstituted ComplexBioGRID7775583 
TLN1ILWEQ | KIAA1027 | TLNtalin 1-HPRD10827173 
TTRHsT2651 | PALB | TBPAtransthyretin-HPRD10982792 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HEDGEHOG_SIGNALING_PATHWAY 5642All SZGR genes in this pathway
PID_HEDGEHOG_2PATHWAY 2217All SZGR genes in this pathway
REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D 3523All SZGR genes in this pathway
REACTOME_STEROID_HORMONES 2921All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
BECKER_TAMOXIFEN_RESISTANCE_DN 5237All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
LOPEZ_EPITHELIOID_MESOTHELIOMA 1711All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_11 10368All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101106910761A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-1395605671A,m8hsa-miR-139brainUCUACAGUGCACGUGUCU
miR-142-5p8692m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-144107010761Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-15/16/195/424/49714411447m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-1938451A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-204/211100010071A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-409-3p76831A,m8hsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
miR-45541471Ahsa-miR-455UAUGUGCCUUUGGACUACAUCG
miR-93.hd/291-3p/294/295/302/372/373/5204694761A,m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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