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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: ARNT

Summary

GeneID

405

Symbol

ARNT

Synonyms

HIF-1beta|HIF1B|HIF1BETA|TANGO|bHLHe2

Description

aryl hydrocarbon receptor nuclear translocator

Locus tag

Gene type

protein-coding

Map location

1q21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0235

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.00814

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

AL117209.1

0.86

0.85

MAGI2

0.85

TATDN2

0.85

0.83

INPP4A

0.84

0.86

BRPF3

0.84

0.85

MAPRE2

0.84

ATCAY

0.84

0.86

MSMP

0.84

0.85

DNAJC5

0.84

0.86

RGP1

0.84

0.86

Top 10 negatively co-expressed genes

AF347015.21

-0.68

-0.62

GNG11

-0.65

-0.63

HIGD1B

-0.64

-0.61

AF347015.31

-0.63

-0.59

MT-CO2

-0.63

-0.58

C1orf54

-0.62

-0.67

AL138743.2

-0.62

-0.64

AP002478.3

-0.60

-0.59

IL32

-0.59

-0.53

NOSTRIN

-0.59

-0.54

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004872

receptor activity

IEA

GO:0004871

signal transducer activity

IEA

GO:0003700

transcription factor activity

IEA

GO:0003705

RNA polymerase II transcription factor activity, enhancer binding

IDA

7539918 |8756616

GO:0003713

transcription coactivator activity

IEA

GO:0003713

transcription coactivator activity

TAS

1317062

GO:0017162

aryl hydrocarbon receptor binding

IPI

9079689

GO:0046982

protein heterodimerization activity

IEA

GO:0046982

protein heterodimerization activity

IPI

9079689

GO:0043565

sequence-specific DNA binding

IDA

7539918 |8756616

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0001666

response to hypoxia

IDA

8756616

GO:0001892

embryonic placenta development

IEA

GO:0001938

positive regulation of endothelial cell proliferation

8756616

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0010575

positive regulation vascular endothelial growth factor production

IDA

8756616

GO:0007165

signal transduction

IEA

GO:0030154

cell differentiation

IEA

GO:0043193

positive regulation of gene-specific transcription

IDA

8089148

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

8756616

GO:0042789

mRNA transcription from RNA polymerase II promoter

7539918

GO:0045648

positive regulation of erythrocyte differentiation

1448077

GO:0045941

positive regulation of transcription

IEA

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IEA

GO:0046886

positive regulation of hormone biosynthetic process

IDA

1448077

GO:0045821

positive regulation of glycolysis

8089148

GO:0043619

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

IDA

8089148

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IEA

GO:0005634

nucleus

TAS

1317062

GO:0005667

transcription factor complex

IEA

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AHR	-	aryl hydrocarbon receptor	-	HPRD	7488247 \|7628454 \|8384309 \|11768231 \|12024042
			Arnt interacts with AhR.	BIND	9704006
			Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	7488247 \|7628454 \|8384309 \|9887096
AHRR	AHH \| AHHR \| KIAA1234 \| MGC167813 \| MGC176630	aryl-hydrocarbon receptor repressor	-	HPRD,BioGRID	9887096
AIP	ARA9 \| FKBP16 \| FKBP37 \| SMTPHN \| XAP2	aryl hydrocarbon receptor interacting protein	-	HPRD,BioGRID	9111057
ARNT	HIF-1beta \| HIF1B \| HIF1BETA \| TANGO \| bHLHe2	aryl hydrocarbon receptor nuclear translocator	Arnt interacts with another copy of itself, albeit weakly, to form a homodimer.	BIND	9704006
EPAS1	ECYT4 \| HIF2A \| HLF \| MOP2 \| PASD2	endothelial PAS domain protein 1	HLF interacts with Arnt. This interaction was modeled on a demonstrated interaction between mouse HLF and human Arnt.	BIND	9113979
			-	HPRD,BioGRID	9079689
			Arnt interacts with HLF. This interaction was modeled on a demonstrated interaction between human Arnt and mouse HLF.	BIND	9704006
GTF2F1	BTF4 \| RAP74 \| TF2F1 \| TFIIF	general transcription factor IIF, polypeptide 1, 74kDa	Reconstituted Complex	BioGRID	8794892
GTF2F2	BTF4 \| RAP30 \| TF2F2 \| TFIIF	general transcription factor IIF, polypeptide 2, 30kDa	-	HPRD,BioGRID	8794892
HIF1A	HIF-1alpha \| HIF1 \| HIF1-ALPHA \| MOP1 \| PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	-	HPRD,BioGRID	9079689
			HIF-1alpha interacts with HIF-1beta	BIND	8663540
			HIF-1alpha isoform 1 interacts with HIF-1beta isoform 3	BIND	8663540
			Arnt interacts with HIF1-alpha.	BIND	9704006
			HIF-1alpha isoform 2 interacts with HIF-1beta isoform 1	BIND	8663540
			HIF-1alpha isoform 2 interacts with HIF-1beta isoform 3	BIND	8663540
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	Affinity Capture-Western	BioGRID	11013261
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD	10594042
NCOA2	GRIP1 \| KAT13C \| MGC138808 \| NCoA-2 \| TIF2	nuclear receptor coactivator 2	-	HPRD,BioGRID	12024042
NPAS1	MOP5 \| PASD5 \| bHLHe11	neuronal PAS domain protein 1	NPAS1 interacts with Arnt	BIND	15635607
NPAS4	Le-PAS \| NXF \| PASD10	neuronal PAS domain protein 4	-	HPRD,BioGRID	14701734
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	-	HPRD,BioGRID	12354770
PTGES3	P23 \| TEBP \| cPGES	prostaglandin E synthase 3 (cytosolic)	-	HPRD	11879970
PTGES3	P23 \| TEBP \| cPGES	prostaglandin E synthase 3 (cytosolic)	Reconstituted Complex	BioGRID	11259606
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Affinity Capture-Western	BioGRID	9712901
SIM1	bHLHe14	single-minded homolog 1 (Drosophila)	-	HPRD,BioGRID	9020169
SIM2	MGC119447 \| SIM \| bHLHe15	single-minded homolog 2 (Drosophila)	-	HPRD,BioGRID	9020169 \|9271372 \|11782478
SP1	-	Sp1 transcription factor	Reconstituted Complex	BioGRID	10471301
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	12024042
TAZ	BTHS \| CMD3A \| EFE \| EFE2 \| FLJ27390 \| G4.5 \| LVNCX \| Taz1 \| XAP-2	tafazzin	Affinity Capture-Western	BioGRID	12065584
XPO1	CRM1 \| DKFZp686B1823	exportin 1 (CRM1 homolog, yeast)	Affinity Capture-Western	BioGRID	12065584

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA	70	60	All SZGR genes in this pathway
BIOCARTA_EPONFKB_PATHWAY	11	11	All SZGR genes in this pathway
BIOCARTA_HIF_PATHWAY	15	12	All SZGR genes in this pathway
BIOCARTA_VEGF_PATHWAY	29	18	All SZGR genes in this pathway
PID_HIF2PATHWAY	34	29	All SZGR genes in this pathway
PID_HIF1A_PATHWAY	19	12	All SZGR genes in this pathway
PID_HIF1_TFPATHWAY	66	52	All SZGR genes in this pathway
PID_HES_HEY_PATHWAY	48	39	All SZGR genes in this pathway
REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN	25	17	All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP	567	375	All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN	493	298	All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN	241	146	All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_UP	78	48	All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_UP	119	66	All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN	199	124	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP	1821	933	All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP	215	137	All SZGR genes in this pathway
STREICHER_LSM1_TARGETS_UP	44	34	All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_17	25	12	All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_24	14	7	All SZGR genes in this pathway
PATIL_LIVER_CANCER	747	453	All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN	514	319	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK	1442	892	All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN	848	527	All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER	214	139	All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX	795	478	All SZGR genes in this pathway
BYSTROEM_CORRELATED_WITH_IL5_DN	64	47	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN	830	547	All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_DN	264	168	All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_RADIATION	81	59	All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP	226	164	All SZGR genes in this pathway
LIN_MELANOMA_COPY_NUMBER_UP	73	53	All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN	354	216	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN	540	340	All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP	648	398	All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING	246	152	All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP	323	240	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_UP	85	50	All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_DN	207	139	All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP	397	206	All SZGR genes in this pathway
RAO_BOUND_BY_SALL4	227	149	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	1273	1279	m8	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	1273	1279	m8	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-103/107	953	960	1A,m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	953	960	1A,m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-129-5p	1869	1875	m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	1869	1875	m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-135	1298	1304	1A	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1298	1304	1A	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-153	608	614	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-221/222	1883	1890	1A,m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	1883	1890	1A,m8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-29	857	863	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-376c	1585	1591	m8	hsa-miR-376c	AACAUAGAGGAAAUUCCACG
miR-448	608	614	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-450	1869	1875	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-504	1274	1281	1A,m8	hsa-miR-504	AGACCCUGGUCUGCACUCUAU
miR-9	709	715	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.