Gene Page: SMAD2

Summary
GeneID  4087
Symbol  SMAD2
Synonyms  JV18|JV18-1|MADH2|MADR2|MGC22139|MGC34440|hMAD-2|hSMAD2
Description  SMAD family member 2
See related  HGNC:6768|MIM:601366|Ensembl:ENSG00000175387|HPRD:03221|
Locus tag  -
Gene type  protein-coding
Map location  18q21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.0843 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003690double-stranded DNA bindingISS-
GO:0003700transcription factor activityIEA-
GO:0008134transcription factor bindingIPI9702198 
GO:0008134transcription factor bindingISS-
GO:0016563transcription activator activityISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001707mesoderm formationISS-
GO:0006350transcriptionIEA-
GO:0007242intracellular signaling cascadeISS-
GO:0009952anterior/posterior pattern formationISS-
GO:0017015regulation of transforming growth factor beta receptor signaling pathwayIMP14555988 
GO:0051098regulation of bindingISS-
GO:0045165cell fate commitmentISS-
GO:0048340paraxial mesoderm morphogenesisISS-
GO:0045892negative regulation of transcription, DNA-dependentIMP14555988 
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9311995 |9865696 |11100470 
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP10549282 
GO:0005667transcription factor complexISS-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACVR1BACTRIB | ACVRLK4 | ALK4 | SKR2activin A receptor, type IBAffinity Capture-WesternBioGRID9892009 
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1Affinity Capture-WesternBioGRID16362038 
ANAPC10APC10 | DKFZp564L0562 | DOC1anaphase promoting complex subunit 10Affinity Capture-Western
Reconstituted Complex
BioGRID15144564 
Smad2 interacts with APC10.BIND15144564 
AXIN1AXIN | MGC52315axin 1-HPRD11438668 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetBRCA1 interacts with Smad2. This interaction was modeled on a demonstrated interaction between BRCA1 from human and Smad2 from an unspecified species.BIND15735739 
BRCA2BRCC2 | FACD | FAD | FAD1 | FANCB | FANCD | FANCD1breast cancer 2, early onsetAffinity Capture-WesternBioGRID12165866 
CAMK2GCAMK | CAMK-II | CAMKG | FLJ16043 | MGC26678calcium/calmodulin-dependent protein kinase II gammaBiochemical ActivityBioGRID11027280 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDaCo-fractionationBioGRID11102446 
CDC16APC6cell division cycle 16 homolog (S. cerevisiae)-HPRD,BioGRID11691834 
CDC27APC3 | CDC27Hs | D0S1430E | D17S978E | HNUCcell division cycle 27 homolog (S. cerevisiae)-HPRD,BioGRID11691834 
CDK2p33(CDK2)cyclin-dependent kinase 2CDK2 phosphorylates Smad2. This interaction was modelled on a demonstrated interaction between Smad2 from an unspecified species and human CDK2.BIND15241418 
CDK4CMM3 | MGC14458 | PSK-J3cyclin-dependent kinase 4CDK4 phosphorylates Smad2. This interaction was modelled on a demonstrated interaction between Smad2 from an unspecified species and mouse CDK4.BIND15241418 
CREBBPCBP | KAT3A | RSTSCREB binding proteinCBP interacts with Smad2. This interaction was modeled on a demonstrated interaction between mouse CBP and Smad2 from an unspecified species.BIND15750622 
CBP interacts with Smad2. This interaction was modeled on a demonstrated interaction between CBP from an unspecified species and human Smad2.BIND9679056 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD,BioGRID12000714 
DAB2DOC-2 | DOC2 | FLJ26626disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)-HPRD,BioGRID11387212 
DVL1DVL | MGC54245dishevelled, dsh homolog 1 (Drosophila)-HPRD,BioGRID12650946 
E2F4E2F-4E2F transcription factor 4, p107/p130-binding-HPRD12150994 
EID2CRI2 | EID-2 | MGC20452EP300 interacting inhibitor of differentiation 2-HPRD,BioGRID14612439 
EP300KAT3B | p300E1A binding protein p300p300 interacts with Smad2. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human Smad2.BIND9679056 
Affinity Capture-WesternBioGRID10199400 |11371641 
-HPRD11264182 
ERBB2IPERBIN | LAP2erbb2 interacting protein-HPRD,BioGRID12650946 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD,BioGRID11555647 
FOXH1FAST-1 | FAST1forkhead box H1The SIM motif of FoxH1 interacts with Smad2. This interaction was modeled on a demonstrated interaction between human FoxH1 and Smad2 from an unspecified species.BIND15750622 
FoxH1 interacts with Smad2. This interaction was modelled on a demonstrated interaction between FoxH1 from an unspecified species and Smad3 from an unspecified species.BIND15084259 
-HPRD,BioGRID9288972 |9389648 
FOXO3AF6q21 | DKFZp781A0677 | FKHRL1 | FKHRL1P2 | FOXO2 | FOXO3A | MGC12739 | MGC31925forkhead box O3-HPRD15084259 
GLI3ACLS | GCPS | PAP-A | PAPA | PAPA1 | PAPB | PHS | PPDIVGLI-Kruppel family member GLI3-HPRD9843199 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD,BioGRID10199400 
HIPK2DKFZp686K02111 | FLJ23711 | PRO0593homeodomain interacting protein kinase 2-HPRD,BioGRID12874272 
HNF4AFLJ39654 | HNF4 | HNF4a7 | HNF4a8 | HNF4a9 | MODY | MODY1 | NR2A1 | NR2A21 | TCF | TCF14hepatocyte nuclear factor 4, alpha-HPRD11229886 
HOXA9ABD-B | HOX1 | HOX1.7 | HOX1G | MGC1934homeobox A9-HPRD,BioGRID11042172 
INSRCD220 | HHF5insulin receptor-HPRD,BioGRID9092546 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID10220381 |11371641 
LEF1DKFZp586H0919 | TCF1ALPHAlymphoid enhancer-binding factor 1-HPRD,BioGRID10890911 
LEMD3MAN1LEM domain containing 3LEMD3 interacts with Smad2. This interaction was modelled on a demonstrated interaction between human LEMD3 and mouse Smad2.BIND15489854 
MED15ARC105 | CAG7A | CTG7A | DKFZp686A2214 | DKFZp762B1216 | FLJ42282 | FLJ42935 | PCQAP | TIG-1 | TIG1 | TNRC7mediator complex subunit 15-HPRD12167862 
MEF2AADCAD1 | RSRFC4 | RSRFC9myocyte enhancer factor 2A-HPRD,BioGRID11160896 
MEF2C-myocyte enhancer factor 2C-HPRD,BioGRID11160896 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD,BioGRID11804592 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9-HPRD,BioGRID11118211 
NFYCCBF-C | CBFC | DKFZp667G242 | FLJ45775 | H1TF2A | HAP5 | HSM | NF-YCnuclear transcription factor Y, gamma-HPRD,BioGRID12023901 
NUP153HNUP153 | N153nucleoporin 153kDa-HPRD12191473 
NUP214CAIN | CAN | D9S46E | MGC104525 | N214nucleoporin 214kDa-HPRD12191473 
PARD3ASIP | Baz | Bazooka | FLJ21015 | PAR3 | PAR3alpha | PARD3A | SE2-5L16 | SE2-5LT1 | SE2-5T2par-3 partitioning defective 3 homolog (C. elegans)-HPRD12650946 
PARD3BALS2CR19 | MGC16131 | PAR3B | PAR3L | PAR3LC | PAR3beta | Par3Lbpar-3 partitioning defective 3 homolog B (C. elegans)Reconstituted ComplexBioGRID12650946 
PIAS3FLJ14651 | ZMIZ5protein inhibitor of activated STAT, 3-HPRD,BioGRID14691252 
PIAS4FLJ12419 | MGC35296 | PIASY | Piasg | ZMIZ6protein inhibitor of activated STAT, 4Affinity Capture-WesternBioGRID12815042 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD,BioGRID15356634 
cPML interacts with Smad2.BIND15356634 
RBL1CP107 | MGC40006 | PRB1 | p107retinoblastoma-like 1 (p107)-HPRD12150994 
RUNX1AML1 | AML1-EVI-1 | AMLCR1 | CBFA2 | EVI-1 | PEBP2aBrunt-related transcription factor 1Affinity Capture-WesternBioGRID10531362 
RUNX2AML3 | CBFA1 | CCD | CCD1 | MGC120022 | MGC120023 | OSF2 | PEA2aA | PEBP2A1 | PEBP2A2 | PEBP2aA | PEBP2aA1runt-related transcription factor 2-HPRD,BioGRID10531362 
RUNX3AML2 | CBFA3 | FLJ34510 | MGC16070 | PEBP2aCrunt-related transcription factor 3Affinity Capture-WesternBioGRID10531362 
SKISKVv-ski sarcoma viral oncogene homolog (avian)c-Ski interacts with Smad2. This interaction was modeled on a demonstrated interaction between Smad2 from an unspecified source and human c-Ski.BIND10575014 
-HPRD,BioGRID10485843 
SKILSNO | SnoA | SnoNSKI-like oncogeneSmad2 interacts with SnoN. This interaction was modeled on a demonstrated interaction between SnoN from an unspecified source and human Smad2.BIND12426322 
-HPRD,BioGRID10531062 |11691834 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3Smad2 interacts with Smad3. This interaction was modeled on a demonstrated interaction between Smad2 from an unspecified species and Smad3 from an unspecified species.BIND9311995 
SMAD3 interacts with SMAD2.BIND15761153 
-HPRD,BioGRID9311995 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD,BioGRID11274206 
Smad4 interacts with Smad2.BIND15761153 
Smad2 interacts with Smad4. This interaction was modeled on a demonstrated interaction between Smad2 from an unspecified species and Smad4 from an unspecified species.BIND9311995 
SMAD7CRCS3 | FLJ16482 | MADH7 | MADH8SMAD family member 7Phenotypic SuppressionBioGRID9892009 
SMURF2DKFZp686F0270 | MGC138150SMAD specific E3 ubiquitin protein ligase 2SMAD2 interacts with SMURF2.BIND15761153 
-HPRD,BioGRID11016919 
SNIP1FLJ12553 | RP3-423B22.3 | dJ423B22.2Smad nuclear interacting protein 1-HPRD,BioGRID10887155 
SNW1Bx42 | MGC119379 | NCOA-62 | PRPF45 | Prp45 | SKIIP | SKIPSNW domain containing 1SKIP interacts with Smad2. This interaction was modeled on a demonstrated interaction between human SKIP and Smad2 from an unspecified source.BIND11278756 
-HPRD,BioGRID11278756 
SP1-Sp1 transcription factor-HPRD,BioGRID11114293 
STRAPMAWD | PT-WD | UNRIPserine/threonine kinase receptor associated protein-HPRD,BioGRID10757800 
TGFBR1AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1transforming growth factor, beta receptor 1-HPRD9525694 
Co-fractionationBioGRID11102446 
T-beta-RI interacts with Smad2.BIND15761153 
TGFBRAP1TRAP-1 | TRAP1transforming growth factor, beta receptor associated protein 1-HPRD11278302 
TGIF1HPE4 | MGC39747 | MGC5066 | TGIFTGFB-induced factor homeobox 1-HPRD,BioGRID10199400 
TOB1APRO6 | MGC104792 | MGC34446 | PIG49 | TOB | TROB | TROB1transducer of ERBB2, 1-HPRD11163184 
ZEB1AREB6 | BZP | DELTA-EF1 | MGC133261 | NIL-2-A | NIL-2A | NIL2A | TCF8 | ZEB | ZFHEP | ZFHX1Azinc finger E-box binding homeobox 1-HPRD,BioGRID12743038 
ZEB2KIAA0569 | SIP-1 | SIP1 | SMADIP1 | ZFHX1Bzinc finger E-box binding homeobox 2-HPRD10400677 
ZFYVE9MADHIP | NSP | SARA | SMADIPzinc finger, FYVE domain containing 9-HPRD,BioGRID9865696 
ZNF8HF.18 | Zfp128zinc finger protein 8-HPRD12370310 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER 6247All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
BIOCARTA_TGFB_PATHWAY 1914All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_GLYPICAN_1PATHWAY 2720All SZGR genes in this pathway
PID_SMAD2_3PATHWAY 1713All SZGR genes in this pathway
PID_MYC_REPRESS_PATHWAY 6352All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NODAL 1811All SZGR genes in this pathway
REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 2313All SZGR genes in this pathway
REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION 2717All SZGR genes in this pathway
REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 2616All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 3826All SZGR genes in this pathway
REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY 2014All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 6342All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP 9459All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
TURJANSKI_MAPK1_AND_MAPK2_TARGETS 1210All SZGR genes in this pathway
BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER 2219All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
BENPORATH_PROLIFERATION 14780All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP 6238All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH3_21_DN 4929All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_UP 6941All SZGR genes in this pathway
RAMALHO_STEMNESS_UP 206118All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
GU_PDEF_TARGETS_UP 7149All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/9837723778m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-128833683431A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-142-5p4134191Ahsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-148/15283348340m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1511891951Ahsa-miR-151brainACUAGACUGAAGCUCCUUGAGG
miR-155869487011A,m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-18137143m8hsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-24*4044101Ahsa-miR-189GUGCCUACUGAGCUGAUAUCAGU
miR-2783378343m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-329377383m8hsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-93.hd/291-3p/294/295/302/372/373/520112118m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.