Gene Page: MCC

Summary
GeneID  4163
Symbol  MCC
Synonyms  DKFZp762O1615|FLJ38893|FLJ46755|MCC1
Description  mutated in colorectal cancers
See related  HGNC:6935|MIM:159350|Ensembl:ENSG00000171444|HPRD:01157|
Locus tag  -
Gene type  protein-coding
Map location  5q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 12.7012 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CMTM30.770.73
SMO0.750.60
ERBB20.730.56
CENPM0.720.62
NME40.720.68
MFAP20.720.70
CPXM10.720.70
EPHB40.720.64
TGIF20.720.56
CHST140.710.56
Top 10 negatively co-expressed genes
HTATIP2-0.45-0.57
CHN1-0.45-0.58
TESK2-0.44-0.56
HABP4-0.44-0.61
MAP7-0.44-0.61
SEPT8-0.44-0.56
OSBPL1A-0.43-0.59
CBX7-0.43-0.59
CPEB1-0.43-0.58
SNAP25-0.43-0.62
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityTAS1848370 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI14743216 |17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS1848370 
GO:0045786negative regulation of cell cycleIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CBR1CBR | hCBR1carbonyl reductase 1Affinity Capture-MSBioGRID17353931 
CCNA1-cyclin A1Affinity Capture-MSBioGRID17353931 
CLTCCHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034clathrin, heavy chain (Hc)Affinity Capture-MSBioGRID17353931 
CSNK1DHCKIDcasein kinase 1, deltaAffinity Capture-MSBioGRID17353931 
CSNK1EHCKIE | MGC10398casein kinase 1, epsilonAffinity Capture-MSBioGRID17353931 
DFFADFF-45 | DFF1 | ICADDNA fragmentation factor, 45kDa, alpha polypeptideAffinity Capture-MSBioGRID17353931 
EIF3AEIF3 | EIF3S10 | KIAA0139 | P167 | TIF32 | eIF3-p170 | eIF3-theta | p180 | p185eukaryotic translation initiation factor 3, subunit AAffinity Capture-MSBioGRID17353931 
EPRSDKFZp313B047 | EARS | GLUPRORS | PARS | PIG32 | QARS | QPRSglutamyl-prolyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinAffinity Capture-MSBioGRID17353931 
FAM40AFLJ14743 | KIAA1761 | MGC148091 | RP4-773N10.1family with sequence similarity 40, member AAffinity Capture-MSBioGRID17353931 
HPRT1HGPRT | HPRThypoxanthine phosphoribosyltransferase 1Affinity Capture-MSBioGRID17353931 
IARSFLJ20736 | IARS1 | ILRS | PRO0785isoleucyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
KRT18CYK18 | K18keratin 18Affinity Capture-MSBioGRID17353931 
LTA4H-leukotriene A4 hydrolaseAffinity Capture-MSBioGRID17353931 
MARSFLJ35667 | METRS | MTRNSmethionyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
MTHFD1MTHFC | MTHFDmethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetaseAffinity Capture-MSBioGRID17353931 
MYH10MGC134913 | MGC134914 | NMMHCBmyosin, heavy chain 10, non-muscleAffinity Capture-MSBioGRID17353931 
NFKBIBIKBB | TRIP9nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, betaMCC1 interacts with NFKBIB (I-kappa-B-beta).BIND14743216 
PAICSADE2 | ADE2H1 | AIRC | DKFZp781N1372 | MGC1343 | MGC5024 | PAISphosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetaseAffinity Capture-MSBioGRID17353931 
PDCD10CCM3 | MGC1212 | MGC24477 | TFAR15programmed cell death 10Affinity Capture-MSBioGRID17353931 
PFASFGAMS | FGARAT | KIAA0361 | PURLphosphoribosylformylglycinamidine synthaseAffinity Capture-MSBioGRID17353931 
PFKPFLJ40226 | PFK-C | PFKFphosphofructokinase, plateletAffinity Capture-MSBioGRID17353931 
PPP2R1AMGC786 | PR65Aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoformAffinity Capture-MSBioGRID17353931 
PSMD2MGC14274 | P97 | Rpn1 | S2 | TRAP2proteasome (prosome, macropain) 26S subunit, non-ATPase, 2Affinity Capture-MSBioGRID17353931 
PSME3Ki | PA28-gamma | PA28G | REG-GAMMAproteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)Affinity Capture-MSBioGRID17353931 
SNRNP200ASCC3L1 | BRR2 | HELIC2 | U5-200KDsmall nuclear ribonucleoprotein 200kDa (U5)Affinity Capture-MSBioGRID17353931 
STK24MST-3 | MST3 | MST3B | STE20 | STK3serine/threonine kinase 24 (STE20 homolog, yeast)Affinity Capture-MSBioGRID17353931 
STRNMGC125642 | SG2NAstriatin, calmodulin binding proteinAffinity Capture-MSBioGRID17353931 
STRN3SG2NAstriatin, calmodulin binding protein 3Affinity Capture-MSBioGRID17353931 
STRN4FLJ35594 | ZIN | zinedinstriatin, calmodulin binding protein 4Affinity Capture-MSBioGRID17353931 
TARSMGC9344 | ThrRSthreonyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
TPM3FLJ41118 | MGC14582 | MGC3261 | MGC72094 | NEM1 | OK/SW-cl.5 | TM-5 | TM3 | TM30 | TM30nm | TPMsk3 | TRK | hscp30tropomyosin 3Affinity Capture-MSBioGRID17353931 
VCPIBMPFD | MGC131997 | MGC148092 | MGC8560 | TERA | p97valosin-containing proteinAffinity Capture-MSBioGRID17353931 
VDAC1MGC111064 | PORIN | PORIN-31-HLvoltage-dependent anion channel 1Affinity Capture-MSBioGRID17353931 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressorAffinity Capture-MSBioGRID17353931 
VPS35DKFZp434E1211 | DKFZp434P1672 | FLJ10752 | FLJ13588 | FLJ20388 | MEM3vacuolar protein sorting 35 homolog (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
XU_HGF_TARGETS_REPRESSED_BY_AKT1_DN 9558All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP 201127All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
MCCOLLUM_GELDANAMYCIN_RESISTANCE_UP 109All SZGR genes in this pathway
LEIN_CEREBELLUM_MARKERS 8547All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
CADWELL_ATG16L1_TARGETS_DN 7043All SZGR genes in this pathway
CROONQUIST_NRAS_VS_STROMAL_STIMULATION_UP 4126All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD2_DN 4629All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
STAMBOLSKY_RESPONSE_TO_VITAMIN_D3_UP 8448All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_CLASSICAL 162122All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.