Gene Page: ME2

Summary
GeneID  4200
Symbol  ME2
Synonyms  -
Description  malic enzyme 2, NAD(+)-dependent, mitochondrial
See related  HGNC:6984|MIM:154270|Ensembl:ENSG00000082212|HPRD:01103|
Locus tag  -
Gene type  protein-coding
Map location  6p25-p24|18q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TECTA0.460.36
APOB0.460.30
KCNT20.450.39
PNPLA10.430.32
PIK3CG0.420.29
DLG20.410.36
TTN0.400.39
NPBWR10.400.16
GLRA30.400.20
LRRC530.400.24
Top 10 negatively co-expressed genes
PRKCDBP-0.33-0.39
RHOC-0.32-0.43
VEGFB-0.32-0.35
DNAJC4-0.31-0.34
EFEMP2-0.30-0.32
DBI-0.30-0.36
RFXANK-0.30-0.30
SERPINB6-0.30-0.34
TRIP6-0.29-0.32
MYL12A-0.29-0.33
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorIEA-
GO:0005488bindingIEA-
GO:0004470malic enzyme activityIEA-
GO:0004471malate dehydrogenase (decarboxylating) activityTAS1993674 
GO:0016619malate dehydrogenase (oxaloacetate-decarboxylating) activityIEA-
GO:0009055electron carrier activityTAS1993674 
GO:0016491oxidoreductase activityIEA-
GO:0051287NAD bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006108malate metabolic processIEA-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005739mitochondrionIEA-
GO:0005759mitochondrial matrixIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD14760703 
ME2-malic enzyme 2, NAD(+)-dependent, mitochondrial-HPRD12962632 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PYRUVATE_METABOLISM 4026All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP 206111All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_UP 13582All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_UP 14984All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_HIF1A_DN 11078All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_MODERATELY_UP 10969All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
SHIPP_DLBCL_CURED_VS_FATAL_DN 4530All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN 187122All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_ACTIVATED_B_LYMPHOCYTE 8166All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN 193112All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
MOOTHA_GLUCONEOGENESIS 3223All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway
KIM_TIAL1_TARGETS 3222All SZGR genes in this pathway


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