Gene Page: MTR

Summary
GeneID  4548
Symbol  MTR
Synonyms  FLJ33168|FLJ43216|FLJ45386|MS
Description  5-methyltetrahydrofolate-homocysteine methyltransferase
See related  HGNC:7468|MIM:156570|Ensembl:ENSG00000116984|HPRD:01136|
Locus tag  -
Gene type  protein-coding
Map location  1q43
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008705methionine synthase activityEXPglutamate (GO term level: 7)8968737 
GO:0008705methionine synthase activityIEAglutamate (GO term level: 7)-
GO:0004156dihydropteroate synthase activityIEA-
GO:0005515protein bindingIPI17353931 
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0008898homocysteine S-methyltransferase activityIEA-
GO:0008168methyltransferase activityIEA-
GO:0031419cobalamin bindingIEA-
GO:0046872metal ion bindingIEA-
GO:0050897cobalt ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)8968737 
GO:0009086methionine biosynthetic processIEA-
GO:0008652amino acid biosynthetic processIEA-
GO:0009396folic acid and derivative biosynthetic processIEA-
GO:0044237cellular metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP8968737 
GO:0005622intracellularIEA-
GO:0005737cytoplasmIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD14760703 
TSC22D1DKFZp686O19206 | MGC17597 | RP11-269C23.2 | TGFB1I4 | TSC22TSC22 domain family, member 1Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYSTEINE_AND_METHIONINE_METABOLISM 3424All SZGR genes in this pathway
KEGG_ONE_CARBON_POOL_BY_FOLATE 1712All SZGR genes in this pathway
REACTOME_SULFUR_AMINO_ACID_METABOLISM 2417All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_BIOLOGICAL_OXIDATIONS 13991All SZGR genes in this pathway
REACTOME_PHASE_II_CONJUGATION 7042All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
MARIADASON_REGULATED_BY_HISTONE_ACETYLATION_DN 5430All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
NIELSEN_LEIOMYOSARCOMA_UP 1810All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/50660671A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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