Gene Page: NDUFS1

Summary
GeneID  4719
Symbol  NDUFS1
Synonyms  CI-75Kd|MGC26839|PRO1304
Description  NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
See related  HGNC:7707|MIM:157655|Ensembl:ENSG00000023228|HPRD:01145|
Locus tag  -
Gene type  protein-coding
Map location  2q33-q34
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LANCL20.790.84
TMEM660.770.81
NAP1L30.760.80
ZRANB30.760.80
ITFG10.750.78
JAZF10.750.81
AC012652.10.750.82
LRFN50.750.83
PCDHAC20.750.82
TBC1D90.750.82
Top 10 negatively co-expressed genes
AF347015.26-0.55-0.48
AF347015.2-0.54-0.46
MT-CO2-0.53-0.47
AF347015.33-0.53-0.46
FXYD1-0.53-0.44
AF347015.8-0.52-0.47
AF347015.21-0.52-0.44
AC098691.2-0.52-0.55
AF347015.18-0.51-0.51
MT-CYB-0.50-0.44
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003954NADH dehydrogenase activityIEA-
GO:0005506iron ion bindingIEA-
GO:0005515protein bindingIPI15186778 
GO:0008137NADH dehydrogenase (ubiquinone) activityIMP15824269 |16478720 |16870178 
GO:0008137NADH dehydrogenase (ubiquinone) activityNAS9878551 
GO:0009055electron carrier activityNAS1935949 
GO:0046872metal ion bindingIEA-
GO:00515372 iron, 2 sulfur cluster bindingIEA-
GO:00515394 iron, 4 sulfur cluster bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006120mitochondrial electron transport, NADH to ubiquinoneNAS9878551 
GO:0006810transportIEA-
GO:0006800oxygen and reactive oxygen species metabolic processIMP15186778 |16478720 |16870178 
GO:0006915apoptosisIDA15186778 
GO:0022900electron transport chainIEA-
GO:0042773ATP synthesis coupled electron transportIEA-
GO:0045333cellular respirationIMP15186778 |16478720 
GO:0046034ATP metabolic processIMP15186778 
GO:0051881regulation of mitochondrial membrane potentialIMP15186778 |16478720 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005739mitochondrionIEA-
GO:0005747mitochondrial respiratory chain complex IIMP16478720 
GO:0005747mitochondrial respiratory chain complex INAS9878551 
GO:0005758mitochondrial intermembrane spaceIDA15186778 
GO:0016020membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidaseNDUFS1 interacts with caspase-3. This interaction was modeled on a demonstrated interaction between human NDUSF1 and caspase-3 from an unspecified source.BIND15186778 
MDH2M-MDH | MDH | MGC:3559 | MOR1malate dehydrogenase 2, NAD (mitochondrial)-HPRD6439716 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_OXIDATIVE_PHOSPHORYLATION 13573All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_PARKINSONS_DISEASE 13378All SZGR genes in this pathway
KEGG_HUNTINGTONS_DISEASE 185109All SZGR genes in this pathway
REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 14185All SZGR genes in this pathway
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT 7944All SZGR genes in this pathway
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ 9856All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 11785All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP 201127All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
MOOTHA_VOXPHOS 8751All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
MCDOWELL_ACUTE_LUNG_INJURY_UP 4529All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
BURTON_ADIPOGENESIS_6 189112All SZGR genes in this pathway
LEIN_PONS_MARKERS 8959All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_UP 388234All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
MELLMAN_TUT1_TARGETS_DN 4729All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway


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