Gene Page: NEDD4

Summary
GeneID  4734
Symbol  NEDD4
Synonyms  KIAA0093|MGC176705|NEDD4-1|RPF1
Description  neural precursor cell expressed, developmentally down-regulated 4
See related  HGNC:7727|MIM:602278|Ensembl:ENSG00000069869|HPRD:03786|
Locus tag  -
Gene type  protein-coding
Map location  15q
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0132 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BOC0.730.53
PDLIM10.670.40
DCT0.670.00
DPF30.660.38
COL2A10.660.49
HUNK0.650.78
CDON0.640.75
DUSP40.640.83
TNFRSF190.640.67
BHLHE220.630.85
Top 10 negatively co-expressed genes
C5orf53-0.41-0.60
AIFM3-0.41-0.65
PTH1R-0.40-0.59
HLA-F-0.40-0.62
AF347015.27-0.39-0.72
MT-CO2-0.39-0.74
AF347015.31-0.39-0.71
AF347015.33-0.38-0.71
IFI27-0.38-0.72
LDHD-0.38-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI17719543 
GO:0004842ubiquitin-protein ligase activityIEA-
GO:0016874ligase activityIEA-
GO:0016881acid-amino acid ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006464protein modification processIEA-
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000151ubiquitin ligase complexIEA-
GO:0005829cytosolIEA-
GO:0005622intracellularIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANXA13ANX13 | ISA | MGC150460annexin A13-HPRD,BioGRID10871286 
CBLBDKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56Cas-Br-M (murine) ecotropic retroviral transforming sequence b-HPRD,BioGRID12907674 
CDC25CCDC25cell division cycle 25 homolog C (S. pombe)-HPRD,BioGRID10037602 
DAZAP2KIAA0058 | MGC14319 | MGC766 | PRTBDAZ associated protein 2-HPRD11342538 
EPS15AF-1P | AF1P | MLLT5epidermal growth factor receptor pathway substrate 15-HPRD,BioGRID11919637 
GRB10GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSSgrowth factor receptor-bound protein 10-HPRD12697834 
-HPRD10446181 |12697834|12697834 
HGSHRS | ZFYVE8hepatocyte growth factor-regulated tyrosine kinase substrate-HPRD,BioGRID12230472 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptor-HPRD,BioGRID12697834 
LITAFFLJ38636 | MGC116698 | MGC116700 | MGC116701 | MGC125274 | MGC125275 | MGC125276 | PIG7 | SIMPLE | TP53I7lipopolysaccharide-induced TNF factor-HPRD11042109 
N4BP2B3BP | FLJ10680 | KIAA1413NEDD4 binding protein 2-HPRD11717310 
N4BP3KIAA0341Nedd4 binding protein 3-HPRD,BioGRID11717310 
NDFIP1MGC10924 | N4WBP5Nedd4 family interacting protein 1-HPRD11042109|11748237 
NDFIP2FLJ25842 | KIAA1165 | N4wbp5aNedd4 family interacting protein 2-HPRD12050153 |12796489 
|15252135|12796489 
-HPRD,BioGRID12050153 |12796489 
|15252135 
NFE2NF-E2 | p45nuclear factor (erythroid-derived 2), 45kDap45 interacts with NEDD4. This interaction was modeled on a demonstrated interaction between human p45 and mouse NEDD4.BIND9305852 
PMEPA1STAG1 | TMEPAIprostate transmembrane protein, androgen induced 1-HPRD,BioGRID11042109 |12907594 
PRRG2PRGP2proline rich Gla (G-carboxyglutamic acid) 2-HPRD11042109 
SCNN1AENaCa | ENaCalpha | FLJ21883 | SCNEA | SCNN1sodium channel, nonvoltage-gated 1 alpha-HPRD,BioGRID10642508 
-HPRD10212229 |10642508 
|11359767|10642508 
SCNN1BENaCb | ENaCbeta | SCNEBsodium channel, nonvoltage-gated 1, beta-HPRD10212229 |10642508 
|11359767|10642508 
-HPRD,BioGRID10642508 
SCNN1GENaCg | ENaCgamma | PHA1 | SCNEGsodium channel, nonvoltage-gated 1, gamma-HPRD,BioGRID10642508 
-HPRD10212229 |10642508 
|11359767|10642508 
SGK1SGKserum/glucocorticoid regulated kinase 1-HPRD,BioGRID11696533 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1-HPRD,BioGRID12218189 
TP73P73tumor protein p73p73-alpha interacts with an unspecified isoform of Nedd4.BIND15678106 
UBE2D2E2(17)KB2 | PUBC1 | UBC4 | UBC4/5 | UBCH5Bubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)-HPRD,BioGRID9182527 
UBE2D3E2(17)KB3 | MGC43926 | MGC5416 | UBC4/5 | UBCH5Cubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)-HPRD,BioGRID9990509 
UBE2E1UBCH6ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)-HPRD,BioGRID9990509 
UBE2L3E2-F1 | L-UBC | UBCH7 | UbcM4ubiquitin-conjugating enzyme E2L 3-HPRD,BioGRID9990509 
WBP1MGC15305 | WBP-1WW domain binding protein 1-HPRD11042109 
WBP2MGC18269 | WBP-2WW domain binding protein 2-HPRD11042109 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
PID_ERBB4_PATHWAY 3832All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 6645All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_MODERATELY_DN 11064All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
PARK_HSC_VS_MULTIPOTENT_PROGENITORS_UP 1914All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_UP 6544All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P6 9144All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
VANASSE_BCL2_TARGETS_DN 7450All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_UP 7049All SZGR genes in this pathway
HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_DN 5036All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G56_UP 129All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD2_DN 4629All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
BILANGES_SERUM_SENSITIVE_VIA_TSC2 3925All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP 11687All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1283813871Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-14411121118m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-273813881A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-5p9429491A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-376112211281Ahsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-9104810551A,m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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