Gene Page: NF2

Summary
GeneID  4771
Symbol  NF2
Synonyms  ACN|BANF|SCH
Description  neurofibromin 2 (merlin)
See related  HGNC:7773|MIM:607379|Ensembl:ENSG00000186575|HPRD:06980|
Locus tag  -
Gene type  protein-coding
Map location  22q12.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PCBP10.950.95
PSMD30.930.93
SF3B40.930.95
U2AF20.930.92
DEDD0.920.90
EFTUD20.920.92
ACTB0.920.93
DCAKD0.920.90
FTSJ10.920.93
DGCR140.920.93
Top 10 negatively co-expressed genes
MT-CO2-0.80-0.88
AF347015.31-0.79-0.87
AF347015.33-0.78-0.87
AF347015.27-0.78-0.87
AF347015.8-0.77-0.87
MT-CYB-0.76-0.86
AF347015.21-0.74-0.91
AF347015.15-0.73-0.84
FXYD1-0.73-0.83
S100B-0.72-0.82
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005198structural molecule activityIEA-
GO:0008092cytoskeletal protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0014010Schwann cell proliferationIMPGlial (GO term level: 9)17353411 
GO:0001953negative regulation of cell-matrix adhesionTAS17210637 
GO:0008285negative regulation of cell proliferationIDA12444102 
GO:0008285negative regulation of cell proliferationIMP17210637 
GO:0008156negative regulation of DNA replicationIMP17210637 
GO:0007605sensory perception of soundIEA-
GO:0022408negative regulation of cell-cell adhesionIDA17210637 
GO:0042524negative regulation of tyrosine phosphorylation of Stat5 proteinIDA12444102 
GO:0030036actin cytoskeleton organizationIMP9537418 
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 proteinIDA12444102 
GO:0030336negative regulation of cell migrationTAS17210637 
GO:0045786negative regulation of cell cycleIEA-
GO:0046426negative regulation of JAK-STAT cascadeIDA12444102 
GO:0051496positive regulation of stress fiber formationIMP9537418 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0005856cytoskeletonTAS8379998 
GO:0005634nucleusIDA10401006 
GO:0005730nucleolusIDA9537418 
GO:0005737cytoplasmIDA9537418 
GO:0005769early endosomeIDA10861283 
GO:0005886plasma membraneIDA10401006 
GO:0048471perinuclear region of cytoplasmIDA17210637 
GO:0019898extrinsic to membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)-HPRD12356905 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD12118253 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinmerlin interacts with ezrin.BIND10036239 
-HPRD,BioGRID10036239 
HGSHRS | ZFYVE8hepatocyte growth factor-regulated tyrosine kinase substrate-HPRD,BioGRID10861283 |11285248 
merlin interacts with HRS.BIND12444101 
MED281500003D12Rik | DKFZp434N185 | EG1 | magicinmediator complex subunit 28Affinity Capture-Western
Two-hybrid		BioGRID15467741 
-HPRD15175163 
NF2ACN | BANF | SCHneurofibromin 2 (merlin)Merlin interacts with MerlinBIND9703963 
-HPRD,BioGRID11856822 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1Merlin interacts with Pak1BIND14580336 
-HPRD14580336 
PXNFLJ16691paxillin-HPRD,BioGRID12118253 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating proteinAffinity Capture-WesternBioGRID12446789 
SCHIP1FLJ39160 | SCHIP-1schwannomin interacting protein 1-HPRD,BioGRID10669747 
SDCBPMDA-9 | ST1 | SYCL | TACIP18syndecan binding protein (syntenin)Schwannomin interacts with syntenin.BIND11432873 
-HPRD,BioGRID11432873 
SGSM3DKFZp761D051 | MAP | RUSC3 | RUTBC3small G protein signaling modulator 3-HPRD,BioGRID15541357 
SLC9A3R1EBP50 | NHERF | NHERF1 | NPHLOP2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1-HPRD,BioGRID9430655 
Merlin interacts with hNHE-RFBIND9430655 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)Affinity Capture-WesternBioGRID10675333 
SPTBN1ELF | SPTB2 | betaSpIIspectrin, beta, non-erythrocytic 1-HPRD,BioGRID11535133 
TARBP2LOQS | TRBP | TRBP1 | TRBP2TAR (HIV-1) RNA binding protein 2Merlin interacts with TRBP.BIND15123692 
TSC1KIAA0243 | LAM | MGC86987 | TSCtuberous sclerosis 1-HPRD12226091 
Hamartin interacts with Merlin. This interaction was modeled on a demonstrated interaction between human hamartin and moesin from an unspecified species.BIND12226091 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)-HPRD,BioGRID12217955 
 


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