Gene Page: NGF

Summary
GeneID  4803
Symbol  NGF
Synonyms  Beta-NGF|HSAN5|MGC161426|MGC161428|NGFB
Description  nerve growth factor (beta polypeptide)
See related  HGNC:7808|MIM:162030|Ensembl:ENSG00000134259|HPRD:08874|
Locus tag  -
Gene type  protein-coding
Map location  1p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005057receptor signaling protein activityIEA-
GO:0005163nerve growth factor receptor bindingIPI14985763 
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0046928regulation of neurotransmitter secretionIEASynap, Neurotransmitter (GO term level: 9)-
GO:0045773positive regulation of axon extensionIEAaxon (GO term level: 15)-
GO:0045664regulation of neuron differentiationIEAneuron, neurogenesis (GO term level: 9)-
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayEXP16939974 
GO:0007265Ras protein signal transductionEXP11520933 
GO:0007422peripheral nervous system developmentIEA-
GO:0019233sensory perception of painIEA-
GO:0032455nerve growth factor processingEXP12787574 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005796Golgi lumenEXP8615794 |12787574 
GO:0005576extracellular regionEXP11157096 |12787574 |16284401 
GO:0005576extracellular regionIEA-
GO:0005768endosomeEXP7806500 |9182757 |10629055 
|16284401 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
A2MCPAMD5 | DKFZp779B086 | FWP007 | S863-7alpha-2-macroglobulin-HPRD,BioGRID10681572 
MMP7MMP-7 | MPSL1 | PUMP-1matrix metallopeptidase 7 (matrilysin, uterine)-HPRD11729324 
NGFBeta-NGF | HSAN5 | MGC161426 | MGC161428 | NGFBnerve growth factor (beta polypeptide)Interaction between NGF (PDB ID: 1WWW_W) and NGF (PDB ID: 1WWW_V).BIND10490030 
-HPRD9351801 |10708862 
NGF forms a homodimerBIND15131306 
NGFRCD271 | Gp80-LNGFR | TNFRSF16 | p75(NTR) | p75NTRnerve growth factor receptor (TNFR superfamily, member 16)-HPRD,BioGRID14985763 
NGF interacts with p75NTR.BIND14985763 
p75NTR interacts with NGF.BIND15258592 
NTRK1DKFZp781I14186 | MTC | TRK | TRK1 | TRKA | p140-TrkAneurotrophic tyrosine kinase, receptor, type 1Interaction between TrkA (PDB ID: 1WWW_Y) and NGF (PDB ID: 1WWW_W).BIND10490030 
NGF interacts with TrkA. This interaction was modeled on a demonstrated interaction between NGF from human and TrkA from an unspecified species.BIND14985763 
Interaction between TrkA (PDB ID: 1WWW_Y) and NGF (PDB ID: 1WWW_V).BIND10490030 
-HPRD,BioGRID14985763 
Interaction between TrkA (PDB ID: 1WWW_X) and NGF (PDB ID: 1WWW_V).BIND10490030 
Interaction between TrkA (PDB ID: 1WWW_X) and NGF (PDB ID: 1WWW_W).BIND10490030 
PLGDKFZp779M0222plasminogen-HPRD11729324 
SORT1Gp95 | NT3sortilin 1-HPRD,BioGRID14985763 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
BIOCARTA_ERK_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_NGF_PATHWAY 1813All SZGR genes in this pathway
BIOCARTA_CDK5_PATHWAY 1111All SZGR genes in this pathway
BIOCARTA_TRKA_PATHWAY 1210All SZGR genes in this pathway
SA_TRKA_RECEPTOR 1715All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
PID_PI3K_PLC_TRK_PATHWAY 3631All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_ARMS_MEDIATED_ACTIVATION 1717All SZGR genes in this pathway
REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS 1918All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_RAS 2723All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS 3630All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN 1514All SZGR genes in this pathway
REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING 137All SZGR genes in this pathway
REACTOME_PI3K_AKT_ACTIVATION 3829All SZGR genes in this pathway
REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES 128All SZGR genes in this pathway
REACTOME_P75NTR_SIGNALS_VIA_NFKB 1410All SZGR genes in this pathway
REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK 4333All SZGR genes in this pathway
REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS 1510All SZGR genes in this pathway
REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL 118All SZGR genes in this pathway
REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 6043All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
NEWMAN_ERCC6_TARGETS_DN 3924All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_DN 11878All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2 12792All SZGR genes in this pathway
FURUKAWA_DUSP6_TARGETS_PCI35_DN 7440All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
GERY_CEBP_TARGETS 12690All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_UP 6941All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_GAMMA_IN_WS 3322All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_UP 5641All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_UP 10968All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_UP 6242All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP 221135All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
QI_HYPOXIA_TARGETS_OF_HIF1A_AND_FOXA2 3727All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.