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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: NHLH2

Summary

GeneID

4808

Symbol

NHLH2

Synonyms

HEN2|KIAA0490|NSCL2|bHLHa34

Description

nescient helix loop helix 2

Locus tag

Gene type

protein-coding

Map location

1p12-p11

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0235

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.00814

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

EHMT2

0.92

0.94

VPS16A

0.92

RBM10

0.92

0.93

C7orf26

0.91

DAXX

0.91

CXXC1

0.91

0.92

ATRIP

0.91

0.90

USF1

0.91

0.89

ZBTB17

0.91

0.92

PRPF31

0.91

0.92

Top 10 negatively co-expressed genes

AF347015.31

-0.80

-0.87

AF347015.27

-0.79

-0.87

MT-CO2

-0.78

-0.86

AF347015.33

-0.76

-0.84

AF347015.8

-0.75

-0.84

MT-CYB

-0.74

-0.83

AF347015.21

-0.73

-0.90

IFI27

-0.73

-0.83

COPZ2

-0.72

-0.78

AF347015.15

-0.72

-0.82

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003677

DNA binding

IEA

GO:0030528

transcription regulator activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007417

central nervous system development

TAS

Brain (GO term level: 6)

1328219

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0007617

mating behavior

IEA

GO:0007275

multicellular organismal development

IEA

GO:0030154

cell differentiation

IEA

GO:0042698

ovulation cycle

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IEA

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
ODONNELL_TFRC_TARGETS_UP	456	228	All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP	146	99	All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP	293	179	All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN	164	111	All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN	514	319	All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP	380	213	All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP	390	236	All SZGR genes in this pathway
KANNAN_TP53_TARGETS_UP	58	40	All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP	314	201	All SZGR genes in this pathway
BACOLOD_RESISTANCE_TO_ALKYLATING_AGENTS_DN	60	45	All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3	435	318	All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3	590	403	All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES	462	273	All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_UP	166	97	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	618	624	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	618	624	m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-130/301	1014	1020	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-142-5p	1471	1477	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-216	975	982	1A,m8	hsa-miR-216	UAAUCUCAGCUGGCAACUGUG
miR-25/32/92/363/367	1481	1487	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-27	1364	1370	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1364	1370	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	923	930	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-33	1479	1485	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	1479	1485	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-342	1102	1108	1A	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-369-3p	1130	1136	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	1130	1136	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-410	1473	1479	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-431	852	858	1A	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA
miR-488	417	424	1A,m8	hsa-miR-488	CCCAGAUAAUGGCACUCUCAA
miR-494	1347	1354	1A,m8	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-495	969	975	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-9	1427	1433	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-96	900	906	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.