Gene Page: NKX2-2

Summary
GeneID  4821
Symbol  NKX2-2
Synonyms  NKX2.2|NKX2B
Description  NK2 homeobox 2
See related  HGNC:7835|MIM:604612|Ensembl:ENSG00000125820|HPRD:05213|
Locus tag  -
Gene type  protein-coding
Map location  20pter-q11.23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CORT0.690.71
APITD10.680.69
EXOC3L0.650.48
LRRC560.640.69
PLCB20.630.66
KRTCAP30.610.33
WFDC20.590.58
RPP250.590.59
RXRG0.590.31
CASZ10.580.44
Top 10 negatively co-expressed genes
NET1-0.31-0.33
AF347015.2-0.30-0.25
AF347015.26-0.29-0.29
AF347015.15-0.28-0.25
MT-CYB-0.28-0.25
PREX2-0.27-0.30
AF347015.8-0.27-0.23
PITPNC1-0.27-0.26
PTRF-0.27-0.23
EGLN3-0.26-0.23
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0005515protein bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentTASBrain (GO term level: 7)1346742 
GO:0048665neuron fate specificationIEAneuron (GO term level: 10)-
GO:0014003oligodendrocyte developmentIEAaxon, oligodendrocyte, Glial (GO term level: 10)-
GO:0021529spinal cord oligodendrocyte cell differentiationIEAneuron, axon, oligodendrocyte (GO term level: 10)-
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0048468cell developmentIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0031018endocrine pancreas developmentIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0045597positive regulation of cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG 2519All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT 3023All SZGR genes in this pathway
REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS 2015All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 160110All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
ZHOU_PANCREATIC_ENDOCRINE_PROGENITOR 1411All SZGR genes in this pathway
ZHOU_PANCREATIC_BETA_CELL 119All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
RAO_BOUND_BY_SALL4 227149All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-17-5p/20/93.mr/106/519.d4414471Ahsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-1825745811A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-30-5p2532601A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3637147201Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-369-3p971031Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374971041A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-377394400m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-4527157221A,m8hsa-miR-452UGUUUGCAGAGGAAACUGAGAC
miR-543261267m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-965755811Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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