Gene Page: NOTCH3

Summary
GeneID  4854
Symbol  NOTCH3
Synonyms  CADASIL|CASIL
Description  Notch homolog 3 (Drosophila)
See related  HGNC:7883|MIM:600276|Ensembl:ENSG00000074181|HPRD:02607|
Locus tag  -
Gene type  protein-coding
Map location  19p13.2-p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PTPRN0.900.89
GALNT90.860.87
SYP0.850.89
DUSP30.850.86
RASGRF10.850.86
TRPM20.850.87
SYNGR10.850.83
GRIN10.850.83
CNTNAP10.850.86
MFSD40.850.85
Top 10 negatively co-expressed genes
RBMX2-0.43-0.52
KIAA1949-0.43-0.30
SH3BP2-0.43-0.45
C21orf57-0.42-0.42
FAM36A-0.42-0.36
TUBB2B-0.42-0.42
SH2D2A-0.42-0.46
GTF3C6-0.41-0.39
TRAF4-0.41-0.44
FADS2-0.41-0.34
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI17292860 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048663neuron fate commitmentIEAneuron (GO term level: 9)-
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0045665negative regulation of neuron differentiationIEAneuron (GO term level: 10)-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0007219Notch signaling pathwayIEA-
GO:0009653anatomical structure morphogenesisTAS7698746 
GO:0007275multicellular organismal developmentIEA-
GO:0050793regulation of developmental processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS7835890 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DLL1DELTA1 | DL1 | Deltadelta-like 1 (Drosophila)-HPRD,BioGRID11006133 |12482954 
JAG1AGS | AHD | AWS | CD339 | HJ1 | JAGL1 | MGC104644jagged 1 (Alagille syndrome)-HPRD12482954 |14714274 
Reconstituted ComplexBioGRID11006133 
JAG2HJ2 | SER2jagged 2-HPRD,BioGRID11006133 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2B-HPRD11404076 
MAML1KIAA0200 | Mam-1 | Mam1mastermind-like 1 (Drosophila)-HPRD,BioGRID11101851 
NOTCH1TAN1 | hN1Notch homolog 1, translocation-associated (Drosophila)Phenotypic SuppressionBioGRID11404076 
RBPJCBF1 | IGKJRB | IGKJRB1 | KBF2 | MGC61669 | RBP-J | RBPJK | RBPSUH | SUH | cslrecombination signal binding protein for immunoglobulin kappa J region-HPRD11404076 
SNW1Bx42 | MGC119379 | NCOA-62 | PRPF45 | Prp45 | SKIIP | SKIPSNW domain containing 1-HPRD,BioGRID11404076 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_DORSO_VENTRAL_AXIS_FORMATION 2521All SZGR genes in this pathway
KEGG_NOTCH_SIGNALING_PATHWAY 4735All SZGR genes in this pathway
PID_NOTCH_PATHWAY 5949All SZGR genes in this pathway
REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION 2917All SZGR genes in this pathway
REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 4424All SZGR genes in this pathway
REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI 1610All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH3 1210All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY 138All SZGR genes in this pathway
REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR 128All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH 10364All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
LIU_CDX2_TARGETS_UP 3622All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS 5845All SZGR genes in this pathway
KOMMAGANI_TP63_GAMMA_TARGETS 97All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
JEON_SMAD6_TARGETS_DN 1914All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_7 2722All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_2 11476All SZGR genes in this pathway
LEE_LIVER_CANCER_DENA_UP 6040All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
RAMASWAMY_METASTASIS_UP 6643All SZGR genes in this pathway
SATO_SILENCED_BY_DEACETYLATION_IN_PANCREATIC_CANCER 5030All SZGR genes in this pathway
MARCHINI_TRABECTEDIN_RESISTANCE_DN 4934All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
MCCOLLUM_GELDANAMYCIN_RESISTANCE_DN 76All SZGR genes in this pathway
BRUECKNER_TARGETS_OF_MIRLET7A3_UP 11169All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_UP 5241All SZGR genes in this pathway
MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN 6746All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K27ME3 269159All SZGR genes in this pathway
CROONQUIST_STROMAL_STIMULATION_UP 6042All SZGR genes in this pathway
CROONQUIST_NRAS_VS_STROMAL_STIMULATION_DN 9965All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
CHIARETTI_T_ALL_REFRACTORY_TO_THERAPY 3018All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN 11683All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
FUKUSHIMA_TNFSF11_TARGETS 1614All SZGR genes in this pathway
WANG_TNF_TARGETS 2417All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_UP 169105All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2066586641Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-150618624m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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