Gene Page: NSF

Summary
GeneID  4905
Symbol  NSF
Synonyms  SKD2
Description  N-ethylmaleimide-sensitive factor
See related  HGNC:8016|MIM:601633|Ensembl:ENSG00000073969|HPRD:03380|
Locus tag  -
Gene type  protein-coding
Map location  17q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.3048 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0005524ATP bindingIEA-
GO:0016787hydrolase activityIEA-
GO:0017111nucleoside-triphosphatase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0015031protein transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARRB1ARB1 | ARR1arrestin, beta 1-HPRD,BioGRID10196135 
C14orf1ERG28 | NET51chromosome 14 open reading frame 1Two-hybridBioGRID16169070 
CD28MGC138290 | Tp44CD28 moleculeCD28 interacts with NSF.BIND11680900 
EEA1MST105 | MSTP105 | ZFYVE2early endosome antigen 1Co-fractionationBioGRID10458612 
EIF3EEIF3-P48 | EIF3S6 | INT6 | eIF3-p46eukaryotic translation initiation factor 3, subunit ETwo-hybridBioGRID16169070 
FUNDC2DC44 | FLJ33773 | HCBP6 | HCC3 | MGC131676 | MGC2495 | PD03104FUN14 domain containing 2Two-hybridBioGRID16169070 
GABARAPFLJ25768 | MGC120154 | MGC120155 | MM46GABA(A) receptor-associated protein-HPRD11461150 
GABARAPL2ATG8 | GATE-16 | GATE16 | GEF-2 | GEF2GABA(A) receptor-associated protein-like 2-HPRD10747018 
GOSR1GOLIM2 | GOS-28 | GOS28 | GOS28/P28 | GS28 | P28golgi SNAP receptor complex member 1-HPRD8636227 |9325254 
KIAA1377-KIAA1377Two-hybridBioGRID16169070 
LUC7L2CGI-59 | CGI-74 | FLJ10657 | LUC7B2LUC7-like 2 (S. cerevisiae)Two-hybridBioGRID16169070 
NAPASNAPAN-ethylmaleimide-sensitive factor attachment protein, alpha-HPRD,BioGRID9362506 
NSFSKD2N-ethylmaleimide-sensitive factor-HPRD,BioGRID8051214 
RGS20RGSZ1 | ZGAP1regulator of G-protein signaling 20Affinity Capture-MSBioGRID17353931 
RPLP1FLJ27448 | MGC5215 | P1 | RPP1ribosomal protein, large, P1Two-hybridBioGRID16169070 
SAP182HOR0202 | MGC27131 | SAP18pSin3A-associated protein, 18kDaAffinity Capture-MSBioGRID17353931 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)-HPRD7622514 
STX4STX4A | p35-2syntaxin 4-HPRD8973549 
STX8CARBsyntaxin 8-HPRD10683148 
USO1P115 | TAP | VDPUSO1 homolog, vesicle docking protein (yeast)-HPRD10903204 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 4430All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 2823All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS 1611All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_UP 2518All SZGR genes in this pathway
BILBAN_B_CLL_LPL_UP 6339All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
JOHANSSON_BRAIN_CANCER_EARLY_VS_LATE_DN 4535All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_MODERATELY_VS_POORLY_UP 12171All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_UP 2719All SZGR genes in this pathway
MENSSEN_MYC_TARGETS 5335All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_DN 5443All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K9ME3_DN 12071All SZGR genes in this pathway
BERNARD_PPAPDC1B_TARGETS_DN 5839All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_DN 175103All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 298174All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
TERAO_AOX4_TARGETS_HG_UP 2820All SZGR genes in this pathway
HUANG_GATA2_TARGETS_DN 7252All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206101110171Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-2248959011Ahsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-25/32/92/363/367161416201Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-33161216181Ahsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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