Gene Page: NTRK2

Summary
GeneID  4915
Symbol  NTRK2
Synonyms  GP145-TrkB|TRKB
Description  neurotrophic tyrosine kinase, receptor, type 2
See related  HGNC:8032|MIM:600456|Ensembl:ENSG00000148053|HPRD:02712|
Locus tag  -
Gene type  protein-coding
Map location  9q22.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ACOT80.940.90
TUSC20.880.86
MECR0.880.88
UROD0.880.84
MRPL170.870.88
MRPL20.870.85
SDHB0.870.88
C9orf1230.870.83
CDK50.870.84
COX4I10.870.86
Top 10 negatively co-expressed genes
EIF5B-0.50-0.58
AC010300.1-0.47-0.56
AC005921.3-0.46-0.65
SFRS18-0.45-0.59
ZNF814-0.44-0.53
ANKRD36B-0.42-0.57
ANKRD36-0.41-0.54
IL3RA-0.41-0.58
RBM25-0.41-0.38
AF347015.18-0.40-0.18
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityIEAneurite (GO term level: 8)-
GO:0043121neurotrophin bindingTASneuron (GO term level: 5)1710174 
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0007190activation of adenylate cyclase activityEXP16805430 
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayEXP16939974 
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA-
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayTAS1710174 
GO:0006468protein amino acid phosphorylationIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005887integral to plasma membraneTAS1710174 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BDNFMGC34632brain-derived neurotrophic factor-HPRD,BioGRID9312147 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD,BioGRID11157096 
FRS2FRS2A | FRS2alpha | SNT | SNT-1 | SNT1fibroblast growth factor receptor substrate 2Reconstituted ComplexBioGRID10092678 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID9648856 
GIPC1C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2GIPC PDZ domain containing family, member 1-HPRD,BioGRID11251075 
KIDINS220ARMS | MGC163482kinase D-interacting substrate, 220kDa-HPRD15167895 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD12074588 
NCK2GRB4 | NCKbetaNCK adaptor protein 2-HPRD,BioGRID12074588 
NTF3HDNF | MGC129711 | NGF-2 | NGF2 | NT3neurotrophin 3-HPRD,BioGRID8621424 
NTF4NT-4/5 | NT4 | NT5 | NTF5neurotrophin 4Interaction between TRKB (PDB ID: 1HCF_Y) and NTF4 (PDB ID: 1HCF_A).BIND10388563 |10490030 
|10631974 |11263982 
|11738045 
Interaction between TRKB (PDB ID: 1HCF_X) and NTF4 (PDB ID: 1HCF_B).BIND10388563 |10490030 
|10631974 |11263982 
|11738045 
-HPRD,BioGRID11855816 
Interaction between TRKB (PDB ID: 1HCF_Y) and NTF4 (PDB ID: 1HCF_B).BIND10388563 |10490030 
|10631974 |11263982 
|11738045 
Interaction between TRKB (PDB ID: 1HCF_X) and NTF4 (PDB ID: 1HCF_A).BIND10388563 |10490030 
|10631974 |11263982 
|11738045 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Two-hybridBioGRID12074588 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1Reconstituted Complex
Two-hybrid		BioGRID10092678 |12074588 
PTPN1PTP1Bprotein tyrosine phosphatase, non-receptor type 1-HPRD,BioGRID12237455 
SH2B1DKFZp547G1110 | FLJ30542 | KIAA1299 | SH2-B | SH2BSH2B adaptor protein 1Two-hybridBioGRID12074588 
-HPRD9856458 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Reconstituted ComplexBioGRID10092678 
SHC3N-Shc | NSHC | RAI | SHCCSHC (Src homology 2 domain containing) transforming protein 3-HPRD,BioGRID9507002 
SQSTM1A170 | OSIL | PDB3 | ZIP3 | p60 | p62 | p62Bsequestosome 1-HPRD,BioGRID12471037 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_DN 6943All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_DN 9153All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP 9459All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_UP 7762All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
ODONNELL_METASTASIS_DN 2413All SZGR genes in this pathway
MATTIOLI_MULTIPLE_MYELOMA_WITH_14Q32_TRANSLOCATIONS 3625All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER 8864All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_DN 5745All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_E 8944All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 160110All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_MF_UP 4727All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_DN 10267All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_DN 3125All SZGR genes in this pathway
NAKAMURA_METASTASIS 4728All SZGR genes in this pathway
NAKAMURA_METASTASIS_MODEL_UP 4526All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
HUNSBERGER_EXERCISE_REGULATED_GENES 3126All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
DING_LUNG_CANCER_BY_MUTATION_RATE 2018All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN 7447All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_DN 8051All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_UP 266142All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN 9974All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1385075131Ahsa-miR-138brainAGCUGGUGUUGUGAAUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.