Gene Page: OCLN

Summary
GeneID  4950
Symbol  OCLN
Synonyms  -
Description  occludin
See related  HGNC:8104|MIM:602876|Ensembl:ENSG00000197822|HPRD:04191|
Locus tag  -
Gene type  protein-coding
Map location  5q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0107 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LRRC340.810.42
C11orf700.790.39
ARMC40.790.41
PLTP0.790.55
C7orf570.790.28
YSK40.780.25
TTC290.780.34
TEKT10.780.29
SPATA180.780.21
ARMC30.780.34
Top 10 negatively co-expressed genes
ACTR3B-0.23-0.32
A2BP1-0.22-0.24
LMO7-0.22-0.26
ARPP-21-0.22-0.23
SLC26A4-0.21-0.28
ARHGAP20-0.21-0.25
FBXW7-0.21-0.26
ELMOD1-0.21-0.25
CIDEA-0.21-0.27
NDRG1-0.21-0.20
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005198structural molecule activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006461protein complex assemblyTAS10749869 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005923tight junctionIEABrain (GO term level: 10)-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIDA18029348 
GO:0005886plasma membraneTAS8601611 
GO:0030054cell junctionIDA18029348 
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GJB1CMTX | CMTX1 | CX32gap junction protein, beta 1, 32kDa-HPRD,BioGRID10581193 
ITCHAIF4 | AIP4 | NAPP1 | dJ468O1.1itchy E3 ubiquitin protein ligase homolog (mouse)-HPRD11782481 
RAB8BFLJ38125RAB8B, member RAS oncogene familyAffinity Capture-WesternBioGRID12639940 
TJP1DKFZp686M05161 | MGC133289 | ZO-1tight junction protein 1 (zona occludens 1)Affinity Capture-Western
Reconstituted Complex		BioGRID9792688 |12169098 
-HPRD7798316 |9792688 
|10575001 |10601346 
|11700038 |12169098 
TJP2MGC26306 | X104 | ZO-2 | ZO2tight junction protein 2 (zona occludens 2)-HPRD,BioGRID10575001 |14512431 
TJP3MGC119546 | ZO-3tight junction protein 3 (zona occludens 3)-HPRD9531559 
-HPRD10575001 
YES1HsT441 | P61-YES | Yes | c-yesv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1-HPRD,BioGRID11950934 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1221871941A,m8hsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-200bc/429139145m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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