Gene Page: OPHN1

Summary
GeneID  4983
Symbol  OPHN1
Synonyms  MRX60|OPN1
Description  oligophrenin 1
See related  HGNC:8148|MIM:300127|Ensembl:ENSG00000079482|HPRD:02130|
Locus tag  RP6-201G10.1
Gene type  protein-coding
Map location  Xq12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TAL10.870.16
MAB21L10.850.48
KLK100.840.21
ANO20.840.33
SP50.830.27
MC4R0.810.17
MAP4K10.800.26
LEF10.790.21
LMO10.780.41
CEACAM210.780.18
Top 10 negatively co-expressed genes
SLC26A4-0.22-0.30
BAIAP2-0.22-0.22
CACNG3-0.20-0.41
C20orf39-0.20-0.15
C1orf115-0.19-0.29
KIAA1614-0.190.01
GTDC1-0.19-0.01
PIK3IP1-0.19-0.24
SPARCL1-0.19-0.52
KCNJ4-0.18-0.39
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005100Rho GTPase activator activityTAS9582072 
GO:0003779actin bindingIEA-
GO:0005096GTPase activator activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007411axon guidanceTASaxon (GO term level: 13)9582072 
GO:0007399nervous system developmentTASneurite (GO term level: 5)9582072 
GO:0007165signal transductionTAS9582072 
GO:0006930substrate-bound cell migration, cell extensionTAS9582072 
GO:0030036actin cytoskeleton organizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIDA18029348 
GO:0005886plasma membraneIDA18029348 
GO:0015629actin cytoskeletonIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD,BioGRID9582072 |11998687 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD,BioGRID9582072 |11998687 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member A-HPRD,BioGRID9582072 |11998687 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_RHO_PATHWAY 3223All SZGR genes in this pathway
PID_RHOA_REG_PATHWAY 4630All SZGR genes in this pathway
REACTOME_SIGNALING_BY_RHO_GTPASES 11381All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
MATTIOLI_MGUS_VS_PCL 11662All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP 292168All SZGR genes in this pathway
CHANG_POU5F1_TARGETS_UP 1510All SZGR genes in this pathway
STOSSI_RESPONSE_TO_ESTRADIOL 5035All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway


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