Gene Page: OPRM1

Summary
GeneID  4988
Symbol  OPRM1
Synonyms  KIAA0403|MOR|MOR1|OPRM
Description  opioid receptor, mu 1
See related  HGNC:8156|MIM:600018|Ensembl:ENSG00000112038|HPRD:02484|
Locus tag  -
Gene type  protein-coding
Map location  6q24-q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.006 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AVP1.000.27
HCRT1.000.08
PMCH0.99-0.01
TMEM1900.980.05
FMO30.950.05
TMEM1460.94-0.02
FAM81B0.94-0.00
WDR380.930.05
CD360.93-0.15
STOML30.92-0.08
Top 10 negatively co-expressed genes
AC008073.2-0.090.02
FBXO32-0.080.04
NDRG1-0.08-0.06
RTN4RL2-0.070.05
CD163L1-0.070.12
MGLL-0.070.07
AC016910.1-0.07-0.06
ARHGEF2-0.07-0.03
DUSP1-0.070.02
SLC26A4-0.070.02
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004988mu-opioid receptor activityIEA-
GO:0004988mu-opioid receptor activityTAS9689128 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007191dopamine receptor, adenylate cyclase activating pathwayIEAdopamine (GO term level: 12)-
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messengerTAS7905839 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007193G-protein signaling, adenylate cyclase inhibiting pathwayIEA-
GO:0007165signal transductionIEA-
GO:0008285negative regulation of cell proliferationTAS2159143 
GO:0007626locomotory behaviorIEA-
GO:0007600sensory perceptionTAS9689128 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusTAS9242668 
GO:0005624membrane fractionIEA-
GO:0005783endoplasmic reticulumTAS9242668 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS9242668 
GO:0005887integral to plasma membraneTAS7905839 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARF1-ADP-ribosylation factor 1Affinity Capture-WesternBioGRID12519790 
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)-HPRD,BioGRID11457836 
GNA15GNA16guanine nucleotide binding protein (G protein), alpha 15 (Gq class)-HPRD9572309 
GNAI1Giguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1-HPRD,BioGRID12068084 
GNAI2GIP | GNAI2B | H_LUCA15.1 | H_LUCA16.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2-HPRD,BioGRID12068084 
GNAO1DKFZp686O0962 | G-ALPHA-o | GNAOguanine nucleotide binding protein (G protein), alpha activating activity polypeptide O-HPRD,BioGRID8393523 
GPRASP1GASP | GASP1 | KIAA0443G protein-coupled receptor associated sorting protein 1GASP-1 interacts with MOR.BIND15086532 
-HPRD12142540 
OPRD1OPRDopioid receptor, delta 1-HPRD,BioGRID11069979 
PLD2-phospholipase D2-HPRD,BioGRID12519790 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
PID_IL4_2PATHWAY 6543All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING 7856All SZGR genes in this pathway
REACTOME_G_PROTEIN_ACTIVATION 2715All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_DN 9753All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98399405m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-232682741Ahsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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