Gene Page: OTX2

Summary
GeneID  5015
Symbol  OTX2
Synonyms  MCOPS5|MGC45000
Description  orthodenticle homeobox 2
See related  HGNC:8522|MIM:600037|Ensembl:ENSG00000165588|HPRD:07190|
Locus tag  -
Gene type  protein-coding
Map location  14q21-q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityNAS-
GO:0005515protein bindingIEA-
GO:0008190eukaryotic initiation factor 4E bindingTAS15705863 
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentIEABrain (GO term level: 6)-
GO:0007411axon guidanceIDAaxon (GO term level: 13)16267555 
GO:0048663neuron fate commitmentIEAneuron (GO term level: 9)-
GO:0030901midbrain developmentTASBrain (GO term level: 8)15705863 
GO:0030900forebrain developmentTASBrain (GO term level: 8)15705863 
GO:0001708cell fate specificationIEA-
GO:0009953dorsal/ventral pattern formationIEA-
GO:0009952anterior/posterior pattern formationIEA-
GO:0009887organ morphogenesisIEA-
GO:0008589regulation of smoothened signaling pathwayTAS15705863 
GO:0007275multicellular organismal developmentIEA-
GO:0042472inner ear morphogenesisIEA-
GO:0042706eye photoreceptor cell fate commitmentIEA-
GO:0040036regulation of fibroblast growth factor receptor signaling pathwayTAS15705863 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030426growth coneIDAaxon, dendrite (GO term level: 5)16267555 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FOXA2HNF3B | MGC19807 | TCF3Bforkhead box A2-HPRD,BioGRID10623575 
LHX1LIM-1 | LIM1 | MGC126723 | MGC138141LIM homeobox 1Reconstituted ComplexBioGRID10623575 
OTX2MCOPS5 | MGC45000orthodenticle homeobox 2Reconstituted ComplexBioGRID10623575 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KORKOLA_YOLK_SAC_TUMOR 6233All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
LEIN_CHOROID_PLEXUS_MARKERS 10361All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
SASAI_TARGETS_OF_CXCR6_AND_PTCH1_UP 139All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_UP 11265All SZGR genes in this pathway
RAO_BOUND_BY_SALL4 227149All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/20651581A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-1286216271Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-130/3015035091Ahsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1381711771Ahsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-142-5p509515m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-148/1524504561Ahsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1536416471Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-2195585651A,m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-27621627m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-3p4524591A,m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-3746977031Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-4109559621A,m8hsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-4486416471Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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