Gene Page: P2RX4

Summary
GeneID  5025
Symbol  P2RX4
Synonyms  P2X4|P2X4R
Description  purinergic receptor P2X, ligand-gated ion channel, 4
See related  HGNC:8535|MIM:600846|Ensembl:ENSG00000135124|HPRD:09017|
Locus tag  -
Gene type  protein-coding
Map location  12q24.32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingISSNeurotransmitter (GO term level: 4)17785580 
GO:0001614purinergic nucleotide receptor activityIDA9016352 
GO:0001614purinergic nucleotide receptor activityIMP11606481 
GO:0004872receptor activityIEA-
GO:0004931ATP-gated cation channel activityIDA9016352 
GO:0004931ATP-gated cation channel activityIEA-
GO:0005507copper ion bindingISS12819199 
GO:0005524ATP bindingIEA-
GO:0005216ion channel activityIEA-
GO:0008270zinc ion bindingISS12819199 
GO:0042803protein homodimerization activityNAS17895406 
GO:0045296cadherin bindingIPI12088286 
GO:0046982protein heterodimerization activityISS17785580 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0060079regulation of excitatory postsynaptic membrane potentialIEAneuron, Synap (GO term level: 10)-
GO:0002028regulation of sodium ion transportISS17785580 
GO:0001894tissue homeostasisNAS17264311 
GO:0008217regulation of blood pressureIMP11606481 |15130891 
GO:0010524positive regulation of calcium ion transport into cytosolIDA10969036 
GO:0010524positive regulation of calcium ion transport into cytosolIMP10899068 
GO:0007165signal transductionIDA9016352 
GO:0010614negative regulation of cardiac muscle hypertrophyIMP15130891 
GO:0006816calcium ion transportIEA-
GO:0006811ion transportIEA-
GO:0006809nitric oxide biosynthetic processIEA-
GO:0042981regulation of apoptosisIDA17264311 
GO:0042311vasodilationIEA-
GO:0033198response to ATPIDA9016352 
GO:0042118endothelial cell activationTAS12088286 
GO:0032308positive regulation of prostaglandin secretionNAS10899068 
GO:0019233sensory perception of painISS14978347 
GO:0034405response to fluid shear stressIDA10969036 
GO:0050850positive regulation of calcium-mediated signalingIDA10969036 
GO:0050850positive regulation of calcium-mediated signalingIMP10899068 
GO:0045429positive regulation of nitric oxide biosynthetic processNAS10899068 
GO:0055117regulation of cardiac muscle contractionIMP11606481 |15130891 
GO:0055119relaxation of cardiac muscleIMP11606481 |15130891 
GO:0051899membrane depolarizationIDA9016352 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneISS17785580 
GO:0005887integral to plasma membraneTAS9016352 
GO:0048471perinuclear region of cytoplasmIDA12088286 
GO:0030054cell junctionIDA12088286 
GO:0045177apical part of cellIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)Affinity Capture-WesternBioGRID12088286 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP 185126All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP 157104All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINDED_IN_ERYTHROCYTE_UP 4430All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
LE_EGR2_TARGETS_UP 10875All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM 302191All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_DN 14192All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_A 6752All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP 221150All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_UP 217131All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_GROUP1 13676All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
VANLOO_SP3_TARGETS_DN 8947All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-17-5p/20/93.mr/106/519.d3813881A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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