Gene Page: P2RX7

Summary
GeneID  5027
Symbol  P2RX7
Synonyms  MGC20089|P2X7
Description  purinergic receptor P2X, ligand-gated ion channel, 7
See related  HGNC:8537|MIM:602566|Ensembl:ENSG00000089041|HPRD:03977|
Locus tag  -
Gene type  protein-coding
Map location  12q24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingISSNeurotransmitter (GO term level: 4)17785580 
GO:0001530lipopolysaccharide bindingISS-
GO:0001614purinergic nucleotide receptor activityIPI9038151 
GO:0004872receptor activityIEA-
GO:0004931ATP-gated cation channel activityIDA9038151 
GO:0004931ATP-gated cation channel activityIEA-
GO:0005524ATP bindingIEA-
GO:0005216ion channel activityIEA-
GO:0042803protein homodimerization activityNAS17895406 
GO:0046982protein heterodimerization activityISS17785580 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002028regulation of sodium ion transportISS17785580 
GO:0010524positive regulation of calcium ion transport into cytosolIDA9038151 
GO:0007166cell surface receptor linked signal transductionISS-
GO:0006811ion transportIEA-
GO:0006812cation transportIEA-
GO:0042981regulation of apoptosisISS-
GO:0033198response to ATPIDA9038151 
GO:0030501positive regulation of bone mineralizationIEA-
GO:0030501positive regulation of bone mineralizationISS-
GO:0019233sensory perception of painISS-
GO:0032060bleb formationISS-
GO:0043409negative regulation of MAPKKK cascadeISS-
GO:0045779negative regulation of bone resorptionIEA-
GO:0045779negative regulation of bone resorptionISS-
GO:0045919positive regulation of cytolysisISS-
GO:0046931pore complex biogenesisIDA9038151 
GO:0050718positive regulation of interleukin-1 beta secretionIDA17036048 |18089587 
GO:0051495positive regulation of cytoskeleton organizationISS-
GO:0051709regulation of killing of cells of another organismNAS17785580 
GO:0051899membrane depolarizationIDA9038151 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmISS-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneISS17785580 
GO:0005887integral to plasma membraneIC9038151 
GO:0005887integral to plasma membraneIEA-
GO:0032059blebISS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTBPS1TP5BP1actin, beta-HPRD11707406 
SVILDKFZp686A17191supervillin-HPRD11707406 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_THE_NLRP3_INFLAMMASOME 129All SZGR genes in this pathway
REACTOME_INFLAMMASOMES 1712All SZGR genes in this pathway
REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 4633All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 160110All SZGR genes in this pathway
CHANG_IMMORTALIZED_BY_HPV31_DN 6545All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T4 9469All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP 194133All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-186765771m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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