Gene Page: ITSN2

Summary
GeneID  50618
Symbol  ITSN2
Synonyms  KIAA1256|PRO2015|SH3D1B|SH3P18|SWA|SWAP
Description  intersectin 2
See related  HGNC:6184|MIM:604464|Ensembl:ENSG00000198399|HPRD:09193|
Locus tag  -
Gene type  protein-coding
Map location  2pter-p25.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.2362 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005089Rho guanyl-nucleotide exchange factor activityIEA-
GO:0005070SH3/SH2 adaptor activityTAS9630982 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI15231747 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006897endocytosisIEA-
GO:0035023regulation of Rho protein signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCCIPTOK-1 | TOK1BRCA2 and CDKN1A interacting proteinTwo-hybridBioGRID16169070 
KIAA1549FLJ11731 | FLJ38703 | FLJ40644KIAA1549-HPRD12421765 
LSM8YJR022WLSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD,BioGRID15231747 
MEGF10DKFZp781K1852 | FLJ41574 | KIAA1780multiple EGF-like-domains 10-HPRD12421765 
PTNHARP | HBGF8 | HBNF | NEGF1pleiotrophinTwo-hybridBioGRID16169070 
RAD9ARAD9RAD9 homolog A (S. pombe)-HPRD12766152 
SYNJ2INPP5H | KIAA0348 | MGC44422synaptojanin 2-HPRD12421765 
TBL3SAZDtransducin (beta)-like 3Two-hybridBioGRID16169070 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)-HPRD,BioGRID11748279 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_CDC42_REG_PATHWAY 3022All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN 180101All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_UP 9564All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_DN 13797All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP 197135All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_1 5133All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_DN 4130All SZGR genes in this pathway
WANG_TARGETS_OF_MLL_CBP_FUSION_UP 4426All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS 191131All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
ZHAN_EARLY_DIFFERENTIATION_GENES_DN 4229All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2063713771Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-124/506207213m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1285946001Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-144592598m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-148/1524864931A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1531621691A,m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-200bc/4292822881Ahsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-275946011A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-3207047101Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-4212963031A,m8hsa-miR-421GGCCUCAUUAAAUGUUUGUUG
miR-4481631691Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-4521651721A,m8hsa-miR-452UGUUUGCAGAGGAAACUGAGAC
miR-493-5p722728m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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