Gene Page: PAX6

Summary
GeneID  5080
Symbol  PAX6
Synonyms  AN|AN2|D11S812E|MGC17209|MGDA|WAGR
Description  paired box 6
See related  HGNC:8620|MIM:607108|Ensembl:ENSG00000007372|HPRD:06167|
Locus tag  -
Gene type  protein-coding
Map location  11p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS10441571 |10747901 
GO:0005515protein bindingIPI16098226 
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)10747901 
GO:0001654eye developmentTAS10747901 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0009887organ morphogenesisTAS10441571 
GO:0007601visual perceptionTAS10441571 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDX2CDX-3 | CDX3caudal type homeobox 2-HPRD,BioGRID10506141 
EN1-engrailed homeobox 1Reconstituted ComplexBioGRID11069920 
EP300KAT3B | p300E1A binding protein p300Affinity Capture-Western
Reconstituted Complex		BioGRID10506141 
HOXB1HOX2 | HOX2I | Hox-2.9 | MGC116843 | MGC116844 | MGC116845homeobox B1-HPRD,BioGRID11069920 
Pax6 interacts with HoxB1. This interaction was modeled on a demonstrated interaction between zebrafish Pax6 and human HoxB1.BIND11069920 
IPO13IMP13 | KAP13 | KIAA0724 | RANBP13importin 13Kap13 interacts with Pax6.BIND15143176 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID15143176 |16189514 
LHX2LH2 | MGC138390 | hLhx2LIM homeobox 2Reconstituted ComplexBioGRID11069920 
MAFGMGC13090 | MGC20149v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)-HPRD,BioGRID11036080 
MITFMI | WS2A | bHLHe32microphthalmia-associated transcription factor-HPRD,BioGRID11350962 
PAX6AN | AN2 | D11S812E | MGC17209 | MGDA | WAGRpaired box 6Affinity Capture-Western
Reconstituted Complex		BioGRID11069920 
PBX1DKFZp686B09108 | MGC126627pre-B-cell leukemia homeobox 1Pax6 interacts with Pbx1. This interaction was modeled on a demonstrated interaction between zebrafish Pax6 and human Pbx1.BIND11069920 
PKNOX1PREP1 | pkonx1cPBX/knotted 1 homeobox 1Reconstituted ComplexBioGRID11069920 
PROX1-prospero homeobox 1Reconstituted ComplexBioGRID11069920 
RAXMCOP3 | RXretina and anterior neural fold homeobox-HPRD,BioGRID11069920 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1Reconstituted ComplexBioGRID10359315 
SIX3HPE2SIX homeobox 3-HPRD,BioGRID11069920 
SOX2ANOP3 | MCOPS3 | MGC2413SRY (sex determining region Y)-box 2-HPRD,BioGRID11358870 |12710953 
|12923055 
SOX3GHDX | MRGH | PHP | PHPX | SOXBSRY (sex determining region Y)-box 3-HPRD12710953 
TAF1BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDaAffinity Capture-WesternBioGRID10359315 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding protein-HPRD,BioGRID10359315 
VSX2CHX10 | HOX10 | MCOP2 | MCOPCB3 | RET1visual system homeobox 2Reconstituted ComplexBioGRID11069920 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG 2519All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT 3023All SZGR genes in this pathway
REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS 2015All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP 148All SZGR genes in this pathway
REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION 2214All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 1912All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_DN 4828All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
YEMELYANOV_GR_TARGETS_DN 108All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER 8864All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP 292168All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED 10068All SZGR genes in this pathway
TESAR_ALK_TARGETS_HUMAN_ES_5D_UP 55All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
WEBER_METHYLATED_IN_COLON_CANCER 1813All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 5034All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
SATO_SILENCED_EPIGENETICALLY_IN_PANCREATIC_CANCER 4930All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
TESAR_ALK_TARGETS_EPISC_4D_UP 76All SZGR genes in this pathway
TESAR_ALK_AND_JAK_TARGETS_MOUSE_ES_D4_UP 55All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
ZHOU_PANCREATIC_ENDOCRINE_PROGENITOR 1411All SZGR genes in this pathway
ZHOU_PANCREATIC_BETA_CELL 119All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
DUAN_PRDM5_TARGETS 7952All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
ROLEF_GLIS3_TARGETS 3729All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-129-5p5725791A,m8hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-1829759811Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-1909379441A,m8hsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-3635705761Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-365266272m8hsa-miR-365UAAUGCCCCUAAAAAUCCUUAU
miR-369-3p251257m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3752072131Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
miR-4505725781Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
miR-7681687m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
miR-969759811Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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