Gene Page: PDK2

Summary
GeneID  5164
Symbol  PDK2
Synonyms  PDHK2
Description  pyruvate dehydrogenase kinase, isozyme 2
See related  HGNC:8810|MIM:602525|Ensembl:ENSG00000005882|HPRD:03955|
Locus tag  -
Gene type  protein-coding
Map location  17q21.33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HBM0.780.68
PPBP0.770.73
HBG10.760.71
SLC4A10.750.74
ALAS20.750.77
ERAF0.740.76
EPB420.720.73
HEMGN0.710.71
HBA10.700.71
DPEP10.700.72
Top 10 negatively co-expressed genes
C5orf53-0.47-0.67
FBXO2-0.45-0.64
CCNI2-0.45-0.66
HLA-F-0.44-0.61
CA4-0.44-0.63
ASPHD1-0.43-0.61
PTGDS-0.43-0.61
BCL2L2-0.42-0.61
SPARCL1-0.42-0.62
CSRP1-0.42-0.59
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000155two-component sensor activityIEA-
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004740pyruvate dehydrogenase (acetyl-transferring) kinase activityTAS7499431 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006006glucose metabolic processTAS7499431 
GO:0005975carbohydrate metabolic processIEA-
GO:0007165signal transductionIEA-
GO:0016310phosphorylationIEA-
GO:0018106peptidyl-histidine phosphorylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005739mitochondrionIEA-
GO:0005759mitochondrial matrixIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DLATDLTA | PDC-E2 | PDCE2dihydrolipoamide S-acetyltransferase-HPRD,BioGRID12816949 
PDHXDLDBP | E3BP | OPDX | PDX1 | proXpyruvate dehydrogenase complex, component X-HPRD,BioGRID12573248 |12816949 
PDK1-pyruvate dehydrogenase kinase, isozyme 1-HPRD,BioGRID12573248 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_MTOR_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_PTEN_PATHWAY 1814All SZGR genes in this pathway
BIOCARTA_EIF4_PATHWAY 2419All SZGR genes in this pathway
BIOCARTA_IGF1MTOR_PATHWAY 2014All SZGR genes in this pathway
REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE 4832All SZGR genes in this pathway
REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 14185All SZGR genes in this pathway
REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX 139All SZGR genes in this pathway
REACTOME_PYRUVATE_METABOLISM 1914All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
LIU_CMYB_TARGETS_UP 165106All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
BIDUS_METASTASIS_DN 16193All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON 335181All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 160110All SZGR genes in this pathway
WONG_IFNA2_RESISTANCE_DN 3420All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP 203130All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_E2 2821All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 298174All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A5 7032All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
MONTERO_THYROID_CANCER_POOR_SURVIVAL_DN 116All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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