Gene Page: PFAS

Summary
GeneID  5198
Symbol  PFAS
Synonyms  FGAMS|FGARAT|KIAA0361|PURL
Description  phosphoribosylformylglycinamidine synthase
See related  HGNC:8863|MIM:602133|Ensembl:ENSG00000178921|HPRD:09072|
Locus tag  -
Gene type  protein-coding
Map location  17p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0044 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SLC25A40.900.90
PKM20.860.87
TMEM1110.860.85
PPT10.850.84
GHITM0.850.90
FOXRED10.850.80
SNURF0.850.89
NEU10.840.83
PET112L0.840.85
PEX190.840.83
Top 10 negatively co-expressed genes
AC010300.1-0.48-0.57
AF347015.18-0.46-0.33
C10orf108-0.44-0.46
AC005921.3-0.44-0.54
IL3RA-0.41-0.59
HSP90AB4P-0.41-0.46
AC100783.1-0.40-0.39
NSBP1-0.40-0.38
EIF5B-0.40-0.42
ZNF814-0.39-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004642phosphoribosylformylglycinamidine synthase activityEXPglutamate (GO term level: 6)8110788 
GO:0004642phosphoribosylformylglycinamidine synthase activityIDAglutamate (GO term level: 6)10548741 
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0005524ATP bindingIEA-
GO:0016874ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006189'de novo' IMP biosynthetic processNAS10548741 
GO:0006164purine nucleotide biosynthetic processIEA-
GO:0006541glutamine metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP8110788 
GO:0005737cytoplasmNAS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EPB414.1R | EL1 | HEerythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)Affinity Capture-MSBioGRID17353931 
HLA-BAS | HLA-B-7301 | HLA-B73 | HLAB | HLAC | SPDA1major histocompatibility complex, class I, BAffinity Capture-MSBioGRID17353931 
MCCDKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1mutated in colorectal cancersAffinity Capture-MSBioGRID17353931 
TFE3RCCP2 | TFEA | bHLHe33transcription factor binding to IGHM enhancer 3Affinity Capture-MSBioGRID17353931 
TNFRSF10DCD264 | DCR2 | TRAILR4 | TRUNDDtumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domainAffinity Capture-MSBioGRID17353931 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6Affinity Capture-MSBioGRID17353931 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressorAffinity Capture-MSBioGRID17353931 
 


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