Gene Page: PI4KB

Summary
GeneID  5298
Symbol  PI4KB
Synonyms  PI4K-BETA|PI4KIIIbeta|PI4Kbeta|PIK4CB|pi4K92
Description  phosphatidylinositol 4-kinase, catalytic, beta
See related  HGNC:8984|MIM:602758|Ensembl:ENSG00000143393|HPRD:11805|
Locus tag  -
Gene type  protein-coding
Map location  1q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MPPE10.720.66
AC009041.30.710.64
C8orf470.710.52
TDRD50.710.68
C8orf850.700.61
CHRM40.700.58
FHOD10.700.52
AC009041.10.700.61
TTC220.690.51
AP000911.10.680.39
Top 10 negatively co-expressed genes
AF347015.21-0.38-0.32
AF347015.2-0.36-0.30
AF347015.31-0.36-0.32
MT-CO2-0.35-0.31
AF347015.8-0.34-0.30
AF347015.18-0.33-0.27
AF347015.15-0.33-0.29
MT-CYB-0.32-0.30
MT-ATP8-0.32-0.31
AF347015.27-0.31-0.31
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI17353931 
GO:0004428inositol or phosphatidylinositol kinase activityIEA-
GO:00044301-phosphatidylinositol 4-kinase activityTAS9584208 
GO:0016773phosphotransferase activity, alcohol group as acceptorIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006661phosphatidylinositol biosynthetic processTAS9020160 
GO:0007165signal transductionTAS9020160 
GO:0048015phosphoinositide-mediated signalingIEA-
GO:0006898receptor-mediated endocytosisTAS9584208 
GO:0046854phosphoinositide phosphorylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0012505endomembrane systemIEA-
GO:0005794Golgi apparatusIEA-
GO:0005737cytoplasmTAS9584208 
GO:0005739mitochondrionIEA-
GO:0005741mitochondrial outer membraneIEA-
GO:0005768endosomeTAS9584208 
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0030867rough endoplasmic reticulum membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FREQDKFZp761L1223 | FLUP | NCS-1 | NCS1frequenin homolog (Drosophila)Affinity Capture-Western
Reconstituted Complex		BioGRID11526106 |14607934 
-HPRD11526106 |12244129 
|14607934 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide-HPRD15324660 
Affinity Capture-MSBioGRID17353931 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideAffinity Capture-MSBioGRID17353931 
-HPRD15324660 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideAffinity Capture-MSBioGRID17353931 
-HPRD15324660 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_INOSITOL_PHOSPHATE_METABOLISM 5442All SZGR genes in this pathway
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 7656All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE 1710All SZGR genes in this pathway
REACTOME_PHOSPHOLIPID_METABOLISM 198112All SZGR genes in this pathway
REACTOME_PI_METABOLISM 4834All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_DN 229142All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP 13493All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
LIN_MELANOMA_COPY_NUMBER_UP 7353All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP 6229All SZGR genes in this pathway
GU_PDEF_TARGETS_DN 3920All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_UP 3624All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/107443449m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-15/16/195/424/497444450m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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