Gene Page: PLA2G1B

Summary
GeneID  5319
Symbol  PLA2G1B
Synonyms  MGC119834|MGC119835|PLA2|PLA2A|PPLA2
Description  phospholipase A2, group IB (pancreas)
See related  HGNC:9030|MIM:172410|Ensembl:ENSG00000170890|HPRD:01396|
Locus tag  -
Gene type  protein-coding
Map location  12q23-q24.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GRN0.780.80
TRIM80.780.76
LARS20.750.70
NCSTN0.730.67
KIAA20130.720.71
SHC10.720.70
SIDT20.720.72
C2orf180.720.72
SLC35A40.720.71
ATG2A0.720.71
Top 10 negatively co-expressed genes
SYCP3-0.54-0.51
AL050337.1-0.51-0.44
FAM159B-0.50-0.56
AF347015.21-0.48-0.38
AC120053.1-0.45-0.36
SPDYA-0.44-0.37
RP9P-0.44-0.43
NOX1-0.44-0.35
GNG11-0.43-0.31
ACSM3-0.43-0.31
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIDANeurotransmitter (GO term level: 4)1918029 
GO:0004623phospholipase A2 activityIEA-
GO:0005509calcium ion bindingIEA-
GO:0016787hydrolase activityIEA-
GO:0032052bile acid bindingISS7060561 
GO:0043498cell surface bindingIDA1918029 
GO:0047498calcium-dependent phospholipase A2 activityIDA7060561 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000187activation of MAPK activityISS15528384 |16005851 
GO:0002446neutrophil mediated immunityISS16005851 
GO:0016042lipid catabolic processIEA-
GO:0007243protein kinase cascadeISS15528384 
GO:0010552positive regulation of specific transcription from RNA polymerase II promoterISS15528384 
GO:0010524positive regulation of calcium ion transport into cytosolISS15528384 
GO:0007165signal transductionTAS9886417 
GO:0015758glucose transportISS1918029 
GO:0007015actin filament organizationTAS9886417 
GO:0006644phospholipid metabolic processIEA-
GO:0006633fatty acid biosynthetic processIDA1918029 
GO:0051092positive regulation of NF-kappaB transcription factor activityISS15528384 
GO:0032637interleukin-8 productionISS15528384 
GO:0032869cellular response to insulin stimulusISS1918029 
GO:0019370leukotriene biosynthetic processISS16005851 
GO:0030593neutrophil chemotaxisISS16005851 
GO:0032431activation of phospholipase A2TAS17981679 
GO:0045740positive regulation of DNA replicationIDA1918029 
GO:0048146positive regulation of fibroblast proliferationIC1918029 
GO:0050714positive regulation of protein secretionTAS17981679 
GO:0050778positive regulation of immune responseISS16005851 
GO:0044240multicellular organismal lipid catabolic processIDA7060561 
GO:0046470phosphatidylcholine metabolic processIDA7060561 
GO:0050482arachidonic acid secretionTAS12423354 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA7060561 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
PLA2G2AMOM1 | PLA2 | PLA2B | PLA2L | PLA2S | PLAS1 | sPLA2phospholipase A2, group IIA (platelets, synovial fluid)Reconstituted ComplexBioGRID7721806 
PLAADOA1 | FLJ11281 | FLJ12699 | PLA2P | PLAPphospholipase A2-activating protein-HPRD2052621 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 7735All SZGR genes in this pathway
KEGG_ETHER_LIPID_METABOLISM 3315All SZGR genes in this pathway
KEGG_ARACHIDONIC_ACID_METABOLISM 5836All SZGR genes in this pathway
KEGG_LINOLEIC_ACID_METABOLISM 2916All SZGR genes in this pathway
KEGG_ALPHA_LINOLENIC_ACID_METABOLISM 199All SZGR genes in this pathway
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY 7653All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 7958All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
PID_FCER1_PATHWAY 6243All SZGR genes in this pathway
REACTOME_ACYL_CHAIN_REMODELLING_OF_PI 158All SZGR genes in this pathway
REACTOME_ACYL_CHAIN_REMODELLING_OF_PC 2213All SZGR genes in this pathway
REACTOME_PHOSPHOLIPID_METABOLISM 198112All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_PA 2714All SZGR genes in this pathway
REACTOME_ACYL_CHAIN_REMODELLING_OF_PG 168All SZGR genes in this pathway
REACTOME_ACYL_CHAIN_REMODELLING_OF_PE 2113All SZGR genes in this pathway
REACTOME_ACYL_CHAIN_REMODELLING_OF_PS 157All SZGR genes in this pathway
REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS 8239All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
LEE_LIVER_CANCER_DENA_DN 7445All SZGR genes in this pathway
CHANG_IMMORTALIZED_BY_HPV31_DN 6545All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_DN 8859All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway


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