Gene Page: PLAU

Summary
GeneID  5328
Symbol  PLAU
Synonyms  ATF|UPA|URK|UROKINASE|u-PA
Description  plasminogen activator, urokinase
See related  HGNC:9052|MIM:191840|Ensembl:ENSG00000122861|HPRD:01883|
Locus tag  -
Gene type  protein-coding
Map location  10q24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AC135457.10.870.59
WDR380.840.42
C8orf120.840.50
CAPS0.840.38
ZMYND100.840.32
C10orf1050.840.42
SLC47A20.830.23
C1orf880.830.48
C11orf700.830.37
FAM166B0.830.33
Top 10 negatively co-expressed genes
C1orf96-0.35-0.55
PRDM2-0.35-0.54
A2BP1-0.34-0.52
MYT1L-0.34-0.52
NUAK1-0.33-0.50
FBXW7-0.33-0.50
LMO7-0.33-0.55
HECW1-0.33-0.51
FAM49A-0.33-0.53
LDB2-0.33-0.49
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0008233peptidase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0006508proteolysisTAS6589620 
GO:0007165signal transductionTAS10749881 
GO:0007596blood coagulationIEA-
GO:0006935chemotaxisTAS10749881 
GO:0042730fibrinolysisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005886plasma membraneEXP2544876 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homologPhenotypic SuppressionBioGRID10402467 
IGF2RCD222 | CIMPR | M6P-R | MPR1 | MPRIinsulin-like growth factor 2 receptor-HPRD9566979 
LRP2DBS | gp330low density lipoprotein-related protein 2-HPRD,BioGRID8344937 
MAP2K1MAPKK1 | MEK1 | MKK1 | PRKMK1mitogen-activated protein kinase kinase 1Phenotypic SuppressionBioGRID10402467 
NID1NIDnidogen 1-HPRD1499567 
PLATDKFZp686I03148 | T-PA | TPAplasminogen activator, tissue-HPRD,BioGRID7721771 
PLAURCD87 | UPAR | URKRplasminogen activator, urokinase receptor-HPRD,BioGRID3031025 |11501527 
-HPRD11501527 
PLGDKFZp779M0222plasminogen-HPRD2829380 |3920216 
SERPINA5PAI3 | PCI | PLANH3 | PROCIserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5Reconstituted ComplexBioGRID2551064 |2752144 
-HPRD2752144 |9365930 
SERPINB2HsT1201 | PAI | PAI-2 | PAI2 | PLANH2serpin peptidase inhibitor, clade B (ovalbumin), member 2Reconstituted ComplexBioGRID8388810 
-HPRD2161846 
SERPINB6CAP | DKFZp686I04222 | MGC111370 | MSTP057 | PI6 | PTI | SPI3serpin peptidase inhibitor, clade B (ovalbumin), member 6-HPRD7548163 
SERPINE1PAI | PAI-1 | PAI1 | PLANH1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1-HPRD2161846 
Reconstituted ComplexBioGRID9184208 
SERPINE2GDN | PI7 | PN1 | PNIserpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2Reconstituted ComplexBioGRID9184208 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-193777783m8hsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-23914920m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-3239149201Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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