Gene Page: POLH

Summary
GeneID  5429
Symbol  POLH
Synonyms  FLJ16395|FLJ21978|RAD30|RAD30A|XP-V|XPV
Description  polymerase (DNA directed), eta
See related  HGNC:9181|MIM:603968|Ensembl:ENSG00000170734|HPRD:04913|
Locus tag  RP11-22I24.1
Gene type  protein-coding
Map location  6p21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000287magnesium ion bindingIEA-
GO:0003684damaged DNA bindingTAS10385124 
GO:0003887DNA-directed DNA polymerase activityTAS10398605 |10871396 
GO:0016779nucleotidyltransferase activityIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000731DNA synthesis during DNA repairIDA17563354 
GO:0006301postreplication repairIEA-
GO:0006290pyrimidine dimer repairIEA-
GO:0006282regulation of DNA repairTAS10398605 
GO:0010225response to UV-CIDA17563354 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005654nucleoplasmTAS10385124 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD14760703 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID11585903 
REV1FLJ21523 | MGC163283 | MGC26225 | REV1LREV1 homolog (S. cerevisiae)hREV1 interacts with POLH.BIND15189446 
-HPRD15189446 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_DNA_REPAIR 11259All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5 9459All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES 14787All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
AFFAR_YY1_TARGETS_DN 234137All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_UP 13995All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
HOLLEMAN_PREDNISOLONE_RESISTANCE_ALL_DN 118All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_UP 16697All SZGR genes in this pathway
GHANDHI_DIRECT_IRRADIATION_UP 11068All SZGR genes in this pathway
WARTERS_RESPONSE_TO_IR_SKIN 8344All SZGR genes in this pathway
WARTERS_IR_RESPONSE_5GY 4723All SZGR genes in this pathway
ZWANG_DOWN_BY_2ND_EGF_PULSE 293119All SZGR genes in this pathway


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