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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: POU3F2

Summary

GeneID

5454

Symbol

POU3F2

Synonyms

BRN2|OCT7|OTF7|POUF3

Description

POU class 3 homeobox 2

Locus tag

Gene type

protein-coding

Map location

6q16

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 2

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003700

transcription factor activity

TAS

7601453 |9482665

GO:0042802

identical protein binding

IPI

11029584

GO:0043565

sequence-specific DNA binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0014002

astrocyte development

IEA

neuron, astrocyte, Glial (GO term level: 10)

GO:0050770

regulation of axonogenesis

IEA

neuron, axon (GO term level: 13)

GO:0006357

regulation of transcription from RNA polymerase II promoter

IEA

GO:0008284

positive regulation of cell proliferation

IDA

15024079

GO:0008544

epidermis development

IEA

GO:0021985

neurohypophysis development

IEA

GO:0021979

hypothalamus cell differentiation

IEA

GO:0040018

positive regulation of multicellular organism growth

IEA

GO:0045595

regulation of cell differentiation

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
EP300	KAT3B \| p300	E1A binding protein p300	Brn-2 interacts with p300.	BIND	11029584
GTF2B	TF2B \| TFIIB	general transcription factor IIB	Brn-2 interacts with TFIIB.	BIND	11029584
PAX3	CDHS \| HUP2 \| MGC120381 \| MGC120382 \| MGC120383 \| MGC120384 \| MGC134778 \| WS1	paired box 3	Brn-2 interacts with Pax3.	BIND	11029584
POU3F2	BRN2 \| OCT7 \| OTF7 \| POUF3	POU class 3 homeobox 2	Brn-2 forms a homodimer.	BIND	11029584
PQBP1	MRX55 \| MRXS3 \| MRXS8 \| NPW38 \| RENS1 \| SHS	polyglutamine binding protein 1	-	HPRD,BioGRID	10332029
SOX10	DOM \| MGC15649 \| WS2E \| WS4	SRY (sex determining region Y)-box 10	Brn-2 interacts with Sox10.	BIND	11029584
SOX11	-	SRY (sex determining region Y)-box 11	-	HPRD	9632656
TBP	GTF2D \| GTF2D1 \| MGC117320 \| MGC126054 \| MGC126055 \| SCA17 \| TFIID	TATA box binding protein	Brn-2 interacts with TBP.	BIND	11029584

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP	1278	748	All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP	238	135	All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_HBZ	41	27	All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_DN	54	37	All SZGR genes in this pathway
BENPORATH_EED_TARGETS	1062	725	All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3	1118	744	All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN	200	112	All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS	74	41	All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN	185	111	All SZGR genes in this pathway
LEE_AGING_MUSCLE_UP	45	33	All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN	61	39	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3	1069	729	All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_DN	69	48	All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3	590	403	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A	898	516	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	1646	1652	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	1646	1652	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-130/301	521	527	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-148/152	522	528	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-15/16/195/424/497	430	436	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-19	520	526	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	520	526	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-199	172	179	1A,m8	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	172	179	1A,m8	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-204/211	1695	1702	1A,m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	1695	1702	1A,m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-218	1678	1684	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-224	1923	1930	1A,m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-27	1646	1652	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1646	1652	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-320	2404	2410	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-378	825	831	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-378	825	831	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-410	2528	2534	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-494	1890	1896	1A	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-494	1890	1896	1A	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-495	1517	1523	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-542-3p	1975	1981	1A	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-544	2256	2263	1A,m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-9	777	783	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.