Gene Page: PPP4C

Summary
GeneID  5531
Symbol  PPP4C
Synonyms  PP4|PPH3|PPX
Description  protein phosphatase 4 (formerly X), catalytic subunit
See related  HGNC:9319|MIM:602035|Ensembl:ENSG00000149923|HPRD:03615|
Locus tag  -
Gene type  protein-coding
Map location  16p12-p11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0033 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PSD30.900.93
APPL10.900.93
AC010896.10.890.91
RABGAP1L0.890.92
LPGAT10.890.92
DMXL20.890.91
LMBRD20.880.91
AKAP110.880.92
RAB11FIP20.880.91
HIPK30.880.91
Top 10 negatively co-expressed genes
C19orf36-0.57-0.64
FXYD1-0.56-0.65
RAB34-0.54-0.66
GSDMD-0.54-0.64
CST3-0.54-0.64
GATSL3-0.54-0.60
HIGD1B-0.54-0.65
TLCD1-0.53-0.61
DCXR-0.53-0.62
EIF4EBP3-0.53-0.61
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004704NF-kappaB-inducing kinase activityNAS9837938 
GO:0005506iron ion bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0004722protein serine/threonine phosphatase activityNAS9837938 
GO:0016787hydrolase activityIEA-
GO:0030145manganese ion bindingIEA-
GO:0046872metal ion bindingNAS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000226microtubule cytoskeleton organizationNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeNAS-
GO:0005634nucleusNAS-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAT3BAG-6 | BAG6 | D6S52E | G3HLA-B associated transcript 3Affinity Capture-MSBioGRID17353931 
CCDC6D10S170 | FLJ32286 | H4 | PTC | TPC | TST1coiled-coil domain containing 6Affinity Capture-MSBioGRID17353931 |18715871 
CCT299D8.1 | CCT-beta | CCTB | MGC142074 | MGC142076 | PRO1633 | TCP-1-betachaperonin containing TCP1, subunit 2 (beta)Affinity Capture-MSBioGRID16085932 |18715871 
CCT3CCT-gamma | CCTG | PIG48 | TCP-1-gamma | TRIC5chaperonin containing TCP1, subunit 3 (gamma)Affinity Capture-MSBioGRID16085932 |18715871 
CCT4CCT-DELTA | Cctd | MGC126164 | MGC126165 | SRBchaperonin containing TCP1, subunit 4 (delta)Affinity Capture-MSBioGRID16085932 |18715871 
CCT5CCT-epsilon | CCTE | KIAA0098 | TCP-1-epsilonchaperonin containing TCP1, subunit 5 (epsilon)Affinity Capture-MSBioGRID16085932 |18715871 
CCT6ACCT-zeta | CCT-zeta-1 | CCT6 | Cctz | HTR3 | MGC126214 | MGC126215 | MoDP-2 | TCP-1-zeta | TCP20 | TCPZ | TTCP20chaperonin containing TCP1, subunit 6A (zeta 1)Affinity Capture-MSBioGRID16085932 |18715871 
CCT7CCT-ETA | Ccth | MGC110985 | Nip7-1 | TCP-1-etachaperonin containing TCP1, subunit 7 (eta)Affinity Capture-MSBioGRID16085932 |18715871 
CCT8C21orf112 | Cctq | D21S246 | KIAA0002 | PRED71chaperonin containing TCP1, subunit 8 (theta)Affinity Capture-MSBioGRID16085932 
DHX38DDX38 | KIAA0224 | PRP16 | PRPF16DEAH (Asp-Glu-Ala-His) box polypeptide 38Affinity Capture-MSBioGRID18715871 
GEMIN4DKFZp434B131 | DKFZp434D174 | HC56 | HCAP1 | HHRF-1 | p97gem (nuclear organelle) associated protein 4Affinity Capture-WesternBioGRID12668731 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3PPP4C (PP4C) interacts with HDAC3.BIND15805470 
IGBP1ALPHA-4 | IBP1immunoglobulin (CD79A) binding protein 1-HPRD,BioGRID9647778 
JUNAP-1 | AP1 | c-Junjun oncogeneReconstituted ComplexBioGRID9837938 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1-HPRD,BioGRID9837938 
PPP2CBPP2CBprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformAffinity Capture-MSBioGRID17353931 
PPP2R1AMGC786 | PR65Aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoformAffinity Capture-MSBioGRID17353931 |18715871 
PPP2R5DB56D | MGC2134 | MGC8949protein phosphatase 2, regulatory subunit B', delta isoformAffinity Capture-MSBioGRID18715871 
PPP4R1PP4(Rmeg) | PP4R1protein phosphatase 4, regulatory subunit 1-HPRD,BioGRID10026142 
PPP4R2MGC131930protein phosphatase 4, regulatory subunit 2-HPRD,BioGRID10769191 
-HPRD10769191 |12668731 
PPP4R4KIAA1622 | PP4R4protein phosphatase 4, regulatory subunit 4Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID18715871 
RELC-Relv-rel reticuloendotheliosis viral oncogene homolog (avian)-HPRD,BioGRID9837938 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD,BioGRID9837938 
SMEK1FLFL1 | KIAA2010 | MSTP033 | PP4R3A | smk-1 | smk1SMEK homolog 1, suppressor of mek1 (Dictyostelium)Affinity Capture-MS
Reconstituted Complex		BioGRID16085932 |17353931 
|18715871 
SMEK2FLFL2 | FLJ31474 | KIAA1387 | PP4R3B | PSY2 | smk1SMEK homolog 2, suppressor of mek1 (Dictyostelium)Affinity Capture-MSBioGRID16085932 |17353931 
|18715871 
SMN1BCD541 | SMA | SMA1 | SMA2 | SMA3 | SMA4 | SMA@ | SMN | SMNT | T-BCD541survival of motor neuron 1, telomericAffinity Capture-WesternBioGRID12668731 
TCP1CCT-alpha | CCT1 | CCTa | D6S230E | TCP-1-alphat-complex 1Affinity Capture-MSBioGRID16085932 |18715871 
TIPRLMGC3794 | TIP | TIP41 | dJ69E11.3TIP41, TOR signaling pathway regulator-like (S. cerevisiae)Affinity Capture-MS
Reconstituted Complex		BioGRID16085932 |17353931 
TMSB4XFX | PTMB4 | TB4X | TMSB4thymosin beta 4, X-linked-HPRD,BioGRID9647778 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Reconstituted ComplexBioGRID9837938 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
CREIGHTON_AKT1_SIGNALING_VIA_MTOR_DN 2316All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP 13493All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP 380213All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
CROMER_METASTASIS_DN 8158All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_DN 6435All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
KESHELAVA_MULTIPLE_DRUG_RESISTANCE 8856All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-12845521A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-274652m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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