Gene Page: PRKACA

Summary
GeneID  5566
Symbol  PRKACA
Synonyms  MGC102831|MGC48865|PKACA
Description  protein kinase, cAMP-dependent, catalytic, alpha
See related  HGNC:9380|MIM:601639|Ensembl:ENSG00000072062|HPRD:03382|
Locus tag  -
Gene type  protein-coding
Map location  19p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 3.3109 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CD2760.960.96
NUP620.960.93
GTF2IRD10.960.95
PCGF20.960.94
PCIF10.950.93
PLXNB20.950.93
PATZ10.950.94
MTA20.950.93
NUP1880.950.94
MIDN0.950.94
Top 10 negatively co-expressed genes
C5orf53-0.73-0.82
HLA-F-0.69-0.71
S100B-0.68-0.82
AF347015.27-0.68-0.87
AF347015.31-0.68-0.88
AIFM3-0.68-0.70
ALDOC-0.68-0.67
FBXO2-0.67-0.61
MT-CO2-0.66-0.87
AF347015.33-0.66-0.85
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI15630084 |17353931 
GO:0005524ATP bindingNAS-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0004691cAMP-dependent protein kinase activityNAS2843813 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationNAS2843813 
GO:0007243protein kinase cascadeEXP12721358 
GO:0009755hormone-mediated signalingEXP12626323 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0005952cAMP-dependent protein kinase complexNAS2843813 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACCN2ASIC | ASIC1 | ASIC1A | BNaC2 | hBNaC2amiloride-sensitive cation channel 2, neuronalBiochemical ActivityBioGRID12578970 
ACCN3ASIC3 | DRASIC | SLNAC1 | TNaC1amiloride-sensitive cation channel 3Biochemical ActivityBioGRID12578970 
AKAP14AKAP28A kinase (PRKA) anchor protein 14-HPRD12475942 
AKAP8LDKFZp434L0650 | HA95 | HAP95 | NAKAP | NAKAP95A kinase (PRKA) anchor protein 8-like-HPRD12950172 
BADBBC2 | BCL2L8BCL2-associated agonist of cell deathReconstituted ComplexBioGRID11500364 
C11orf17AKIP1 | BCA3chromosome 11 open reading frame 17-HPRD,BioGRID15630084 
PRKACA interacts with AKIP1a.BIND15630084 
CAMKK2CAMKK | CAMKKB | KIAA0787 | MGC15254calcium/calmodulin-dependent protein kinase kinase 2, betaBiochemical ActivityBioGRID10187789 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDaAffinity Capture-WesternBioGRID11546661 
CREB1CREB | MGC9284cAMP responsive element binding protein 1Reconstituted ComplexBioGRID11500364 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID9050991 
GABRB3ECA5 | MGC9051gamma-aminobutyric acid (GABA) A receptor, beta 3Reconstituted ComplexBioGRID12595241 
GAD1FLJ45882 | GAD | SCPglutamate decarboxylase 1 (brain, 67kDa)Biochemical ActivityBioGRID15147202 
GAD2GAD65 | MGC161605 | MGC161607glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)Biochemical ActivityBioGRID15147202 
HAND1Hxt | Thing1 | bHLHa27 | eHandheart and neural crest derivatives expressed 1Biochemical ActivityBioGRID14636580 
HAND2DHAND2 | FLJ16260 | Hed | MGC125303 | MGC125304 | Thing2 | bHLHa26 | dHandheart and neural crest derivatives expressed 2Biochemical ActivityBioGRID14636580 
IFNAR1AVP | IFN-alpha-REC | IFNAR | IFNBR | IFRCinterferon (alpha, beta and omega) receptor 1-HPRD9029147 
IQGAP1HUMORFA01 | KIAA0051 | SAR1 | p195IQ motif containing GTPase activating protein 1Affinity Capture-Western
Co-purification		BioGRID12938160 
IRF2DKFZp686F0244 | IRF-2interferon regulatory factor 2Biochemical ActivityBioGRID9213219 
ITPKBIP3K | IP3K-B | IP3KB | PIG37inositol 1,4,5-trisphosphate 3-kinase Bin vitroBioGRID9374536 
KCNQ1ATFB1 | FLJ26167 | JLNS1 | KCNA8 | KCNA9 | KVLQT1 | Kv1.9 | Kv7.1 | LQT | LQT1 | RWS | SQT2 | WRSpotassium voltage-gated channel, KQT-like subfamily, member 1Affinity Capture-Western
Reconstituted Complex		BioGRID11799244 
MGMT-O-6-methylguanine-DNA methyltransferase-HPRD,BioGRID10667577 
NINKIAA1565ninein (GSK3B interacting protein)-HPRD,BioGRID12927815 
NMT1NMTN-myristoyltransferase 1hNMT1 interacts with and myristoylates PRKACA.BIND10734119 
NPR1ANPRA | ANPa | GUC2A | GUCY2A | NPRAnatriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)PRKACA interacts with and phosphorylates NPR1 (NPR-A). This interaction was modelled on a demonstrated interaction between bovine PRKACA and human NPR1.BIND10581150 
PDPK1MGC20087 | MGC35290 | PDK1 | PRO04613-phosphoinositide dependent protein kinase-1Reconstituted Complex
Two-hybrid		BioGRID10698939 
PKIAPRKACN1protein kinase (cAMP-dependent, catalytic) inhibitor alpha-HPRD,BioGRID7905001 |8027074 
PKIGMGC126458 | MGC126459protein kinase (cAMP-dependent, catalytic) inhibitor gammaAffinity Capture-MSBioGRID17353931 
PPP1R8ARD-1 | ARD1 | NIPP-1 | NIPP1 | PRO2047protein phosphatase 1, regulatory (inhibitor) subunit 8Biochemical ActivityBioGRID9407077 
PRKAR1ACAR | CNC | CNC1 | DKFZp779L0468 | MGC17251 | PKR1 | PPNAD1 | PRKAR1 | TSE1protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)Affinity Capture-MSBioGRID17353931 
RASGRP3GRP3 | KIAA0846RAS guanyl releasing protein 3 (calcium and DAG-regulated)Biochemical ActivityBioGRID15213298 
RYR2ARVC2 | ARVD2 | VTSIPryanodine receptor 2 (cardiac)Biochemical Activity
Co-fractionation		BioGRID10830164 
SLC9A3R2E3KARP | MGC104639 | NHE3RF2 | NHERF-2 | NHERF2 | OCTS2 | SIP-1 | SIP1 | TKA-1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2-HPRD12954600 
TRIP10CIP4 | HSTP | STOT | STPthyroid hormone receptor interactor 10Biochemical ActivityBioGRID15047863 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-14981871Ahsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/4976926981Ahsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-335135613621Ahsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-3701471531Ahsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-5036916981A,m8hsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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