Gene Page: ATF7IP

Summary
GeneID  55729
Symbol  ATF7IP
Synonyms  FLJ10139|FLJ10688|MCAF|p621
Description  activating transcription factor 7 interacting protein
See related  HGNC:20092|Ensembl:ENSG00000171681|HPRD:09811|
Locus tag  -
Gene type  protein-coding
Map location  12p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.2159 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GDF10.650.63
SIPA10.550.59
EMILIN10.540.55
NOS30.540.52
CDK2AP20.540.53
LSR0.540.52
PRKCDBP0.540.64
KANK30.540.57
FOXS10.530.55
HMX10.520.51
Top 10 negatively co-expressed genes
SEC62-0.35-0.36
CCDC91-0.34-0.34
FRG1B-0.34-0.31
AC006226.1-0.33-0.36
ZNF208-0.31-0.34
CCDC25-0.31-0.29
VAMP4-0.31-0.30
RP11-298P3.1-0.31-0.26
PPP3R1-0.30-0.27
PITPNB-0.30-0.29
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003714transcription corepressor activityIEA-
GO:0005515protein bindingIPI12665582 
GO:0016887ATPase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA-
GO:0006306DNA methylationIDA12665582 
GO:0006350transcriptionIEA-
GO:0045893positive regulation of transcription, DNA-dependentIDA12665582 
GO:0045898regulation of transcriptional preinitiation complex assemblyIDA12665582 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA12665582 
GO:0005667transcription factor complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DISC1C1orf136 | FLJ13381 | FLJ21640 | FLJ25311 | FLJ41105 | KIAA0457 | SCZD9disrupted in schizophrenia 1DISC-1 interacts with ATF7ip.BIND12812986 
Two-hybridBioGRID12812986 
GTF2E2FE | TF2E2 | TFIIE-Bgeneral transcription factor IIE, polypeptide 2, beta 34kDa-HPRD10777215 
GTF2F1BTF4 | RAP74 | TF2F1 | TFIIFgeneral transcription factor IIF, polypeptide 1, 74kDa-HPRD10777215 
GTF2H1BTF2 | TFB1 | TFIIHgeneral transcription factor IIH, polypeptide 1, 62kDa-HPRD10777215 
MBD1CXXC3 | PCM1 | RFTmethyl-CpG binding domain protein 1MCAF1 interacts with MBD1.BIND15691849 
-HPRD,BioGRID12665582 
POLR2CRPB3 | RPB31 | hRPB33 | hsRPB3polymerase (RNA) II (DNA directed) polypeptide C, 33kDa-HPRD10777215 
POLR2DHSRBP4 | HSRPB4 | RBP4polymerase (RNA) II (DNA directed) polypeptide D-HPRD10777215 
POLR2GMGC138367 | MGC138369 | RPB7 | hRPB19 | hsRPB7polymerase (RNA) II (DNA directed) polypeptide G-HPRD10777215 
SETDB1ESET | KG1T | KIAA0067 | KMT1ESET domain, bifurcated 1-HPRD14536086 
MCAF1 interacts with SETDB1.BIND15691849 
SP1-Sp1 transcription factorMCAF1 interacts with Sp1.BIND15691849 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.16296361A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5066286351A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-142-3p1241311A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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