Gene Page: PRKAR2A

Summary
GeneID  5576
Symbol  PRKAR2A
Synonyms  MGC3606|PKR2|PRKAR2
Description  protein kinase, cAMP-dependent, regulatory, type II, alpha
See related  HGNC:9391|MIM:176910|Ensembl:ENSG00000114302|HPRD:01484|
Locus tag  -
Gene type  protein-coding
Map location  3p21.3-p21.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0096 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NCBP10.900.89
WDR30.890.90
ZMYM40.890.90
CTDSPL20.890.91
CAND10.890.89
SCYL20.890.90
KIAA14300.890.90
IPO50.890.89
NUDT210.890.89
VEZT0.890.90
Top 10 negatively co-expressed genes
MT-CO2-0.73-0.83
AF347015.33-0.72-0.83
FXYD1-0.72-0.84
HLA-F-0.71-0.79
AF347015.31-0.71-0.81
MT-CYB-0.70-0.81
AIFM3-0.70-0.77
HEPN1-0.70-0.78
AF347015.8-0.70-0.82
AF347015.27-0.69-0.81
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0008603cAMP-dependent protein kinase regulator activityIEA-
GO:0008603cAMP-dependent protein kinase regulator activityNAS9003463 
GO:0016301kinase activityIEA-
GO:0030552cAMP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001932regulation of protein amino acid phosphorylationIEA-
GO:0007165signal transductionIEA-
GO:0009755hormone-mediated signalingEXP12626323 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionTAS10799517 
GO:0005737cytoplasmTAS10799517 
GO:0005952cAMP-dependent protein kinase complexIEA-
GO:0005886plasma membraneTAS10799517 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKAP1AKAP | AKAP121 | AKAP149 | AKAP84 | D-AKAP1 | MGC1807 | PRKA1 | SAKAP84A kinase (PRKA) anchor protein 1-HPRD9065479 |10764601 
Far Western
Reconstituted Complex		BioGRID10413680 |10764601 
AKAP10D-AKAP2 | MGC9414 | PRKA10A kinase (PRKA) anchor protein 10-HPRD9326583 
AKAP11AKAP220 | DKFZp781I12161 | FLJ11304 | KIAA0629 | PRKA11A kinase (PRKA) anchor protein 11-HPRD,BioGRID8621616 
AKAP12AKAP250 | DKFZp686M0430 | DKFZp686O0331 | FLJ20945 | FLJ97621A kinase (PRKA) anchor protein 12-HPRD,BioGRID11316952 
AKAP13AKAP-Lbc | BRX | FLJ11952 | FLJ43341 | HA-3 | Ht31 | LBC | PROTO-LB | PROTO-LBC | c-lbcA kinase (PRKA) anchor protein 13-HPRD1618839 |7929081 
-HPRD,BioGRID12672969 
AKAP14AKAP28A kinase (PRKA) anchor protein 14-HPRD,BioGRID12475942 
AKAP2AKAPKL | FLJ53197 | PALM2 | PRKA2A kinase (PRKA) anchor protein 2Far Western
Protein-peptide
Reconstituted Complex		BioGRID9497389 |12672969 
AKAP3AKAP110 | FSP95 | PRKA3 | SOB1A kinase (PRKA) anchor protein 3-HPRD,BioGRID10319321 |11278869 
|11696326 
AKAP4AKAP82 | FSC1 | HI | hAKAP82 | p82A kinase (PRKA) anchor protein 4Reconstituted ComplexBioGRID9852104 
AKAP5AKAP75 | AKAP79 | H21A kinase (PRKA) anchor protein 5-HPRD,BioGRID12672969 
AKAP6ADAP100 | ADAP6 | AKAP100 | KIAA0311 | MGC165020 | PRKA6 | mAKAPA kinase (PRKA) anchor protein 6-HPRD10413680 
Protein-peptideBioGRID12672969 
AKAP7AKAP18A kinase (PRKA) anchor protein 7-HPRD,BioGRID12672969 
AKAP8AKAP95 | DKFZp586B1222A kinase (PRKA) anchor protein 8-HPRD,BioGRID9473338 |10601332 
AKAP9AKAP350 | AKAP450 | CG-NAP | HYPERION | KIAA0803 | MU-RMS-40.16A | PRKA9 | YOTIAOA kinase (PRKA) anchor protein (yotiao) 9-HPRD,BioGRID10358086 
-HPRD10358086 |11799244 
ARFGEF2BIG2 | FLJ23723 | dJ1164I10.1ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)Reconstituted Complex
Two-hybrid		BioGRID12571360 
CBFA2T3ETO2 | MTG16 | MTGR2 | ZMYND4core-binding factor, runt domain, alpha subunit 2; translocated to, 3-HPRD,BioGRID11823486 
CFTRABC35 | ABCC7 | CF | CFTR/MRP | MRP7 | TNR-CFTR | dJ760C5.1cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)PKA II interacts with and phosphorylates CFTR.BIND10799517 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinPKA II interacts with Ezrin.BIND9009265 |10799517 
|12080047 
GNA13G13 | MGC46138guanine nucleotide binding protein (G protein), alpha 13Affinity Capture-WesternBioGRID11696326 
GSK3B-glycogen synthase kinase 3 betaAffinity Capture-WesternBioGRID12147701 
KCNQ1ATFB1 | FLJ26167 | JLNS1 | KCNA8 | KCNA9 | KVLQT1 | Kv1.9 | Kv7.1 | LQT | LQT1 | RWS | SQT2 | WRSpotassium voltage-gated channel, KQT-like subfamily, member 1Affinity Capture-WesternBioGRID11799244 
MYCBPAPAMAP-1 | AMAP1 | DKFZp434N1415MYCBP associated protein-HPRD12151104 
NBEABCL8B | LYST2neurobeachin-HPRD11102458 
PALM2-AKAP2AKAP2 | DKFZp686H1948PALM2-AKAP2 readthrough transcript-HPRD9497389 |12672969 
PDE4ADPDE2 | PDE4 | PDE46phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)Affinity Capture-WesternBioGRID11296225 
PRKAR2AMGC3606 | PKR2 | PRKAR2protein kinase, cAMP-dependent, regulatory, type II, alphaPKA forms a dimer. This interaction was modeled on a demonstrated interaction between mouse PKA (PDB ID: 1L6E_B) and mouse PKA (PDB ID: 1L6E_A).BIND9295304 |10074940 
|11985580 
RAB32-RAB32, member RAS oncogene familyFar Western
Protein-peptide
Two-hybrid		BioGRID12186851 |12672969 
RUNX1T1AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2runt-related transcription factor 1; translocated to, 1 (cyclin D-related)-HPRD,BioGRID11593431 
RYR2ARVC2 | ARVD2 | VTSIPryanodine receptor 2 (cardiac)-HPRD,BioGRID10830164 
WASF1FLJ31482 | KIAA0269 | SCAR1 | WAVE | WAVE1WAS protein family, member 1WAVE-1 interacts with PKA.BIND10970852 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
BIOCARTA_NO1_PATHWAY 3324All SZGR genes in this pathway
BIOCARTA_CSK_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_AKAP95_PATHWAY 129All SZGR genes in this pathway
BIOCARTA_AGPCR_PATHWAY 1312All SZGR genes in this pathway
BIOCARTA_CFTR_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_GATA3_PATHWAY 1615All SZGR genes in this pathway
BIOCARTA_MPR_PATHWAY 3428All SZGR genes in this pathway
BIOCARTA_MCALPAIN_PATHWAY 2516All SZGR genes in this pathway
BIOCARTA_PPARA_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_IGF1R_PATHWAY 2320All SZGR genes in this pathway
BIOCARTA_VIP_PATHWAY 2926All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
BIOCARTA_NOS1_PATHWAY 2421All SZGR genes in this pathway
BIOCARTA_PLCE_PATHWAY 1210All SZGR genes in this pathway
BIOCARTA_AKAPCENTROSOME_PATHWAY 1514All SZGR genes in this pathway
BIOCARTA_CHREBP2_PATHWAY 4235All SZGR genes in this pathway
BIOCARTA_BAD_PATHWAY 2623All SZGR genes in this pathway
BIOCARTA_CK1_PATHWAY 1717All SZGR genes in this pathway
BIOCARTA_DREAM_PATHWAY 1413All SZGR genes in this pathway
BIOCARTA_AKAP13_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY 3731All SZGR genes in this pathway
BIOCARTA_SHH_PATHWAY 1615All SZGR genes in this pathway
BIOCARTA_STATHMIN_PATHWAY 1917All SZGR genes in this pathway
BIOCARTA_CREB_PATHWAY 2725All SZGR genes in this pathway
BIOCARTA_CARM1_PATHWAY 1311All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_DAG_AND_IP3_SIGNALING 3225All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER 10980All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING 7856All SZGR genes in this pathway
REACTOME_CA_DEPENDENT_EVENTS 3023All SZGR genes in this pathway
REACTOME_DARPP_32_EVENTS 2520All SZGR genes in this pathway
REACTOME_PLC_BETA_MEDIATED_EVENTS 4332All SZGR genes in this pathway
REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB 1814All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION 3423All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 4328All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 10074All SZGR genes in this pathway
REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE 5440All SZGR genes in this pathway
REACTOME_AQUAPORIN_MEDIATED_TRANSPORT 5134All SZGR genes in this pathway
REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS 4430All SZGR genes in this pathway
REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 132101All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_4 6134All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN 6445All SZGR genes in this pathway
SU_TESTIS 7653All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1 9175All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
HOFMANN_MYELODYSPLASTIC_SYNDROM_HIGH_RISK_UP 107All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-149842848m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/4973413481A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-1852782851A,m8hsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-378*3073141A,m8hsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-5033423481Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-504846852m8hsa-miR-504AGACCCUGGUCUGCACUCUAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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