Gene Page: DCP1A

Summary
GeneID  55802
Symbol  DCP1A
Synonyms  FLJ21691|HSA275986|Nbla00360|SMAD4IP1|SMIF
Description  DCP1 decapping enzyme homolog A (S. cerevisiae)
See related  HGNC:18714|MIM:607010|HPRD:06113|
Locus tag  -
Gene type  protein-coding
Map location  3p21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.7979 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
VWA5A0.710.74
MATN20.710.67
NHSL20.680.68
ARHGAP60.630.61
BCO20.610.67
CAPS20.610.69
BAIAP30.610.71
DOCK100.600.67
TLL20.600.69
PAM0.600.74
Top 10 negatively co-expressed genes
NR2C2AP-0.32-0.36
EMID1-0.32-0.43
RPL18-0.31-0.49
IGFBP2-0.31-0.41
MPPED1-0.30-0.23
SLA-0.30-0.16
ISLR2-0.30-0.17
OLFM2-0.30-0.37
NEUROD6-0.30-0.27
RPS18-0.30-0.45
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12417715 |15231747 |16364915 
GO:0016787hydrolase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DCP2FLJ33245 | NUDT20DCP2 decapping enzyme homolog (S. cerevisiae)-HPRD,BioGRID12417715 
EIF2C1AGO1 | DKFZp686M13167 | EIF2C | GERP95 | Q99eukaryotic translation initiation factor 2C, 1EIF2C1 (Ago1) interacts with DCP1A.BIND15937477 
EIF2C2AGO2 | MGC3183 | Q10eukaryotic translation initiation factor 2C, 2EIF2C2 (Ago2) interacts with DCP1A.BIND15937477 
LSM8YJR022WLSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)Two-hybridBioGRID15231747 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD,BioGRID11836524 
TTF2HuF2transcription termination factor, RNA polymerase IIHuF2 interacts with SMIF TF.BIND12927788 
-HPRD,BioGRID12927788 
UPF1FLJ43809 | FLJ46894 | HUPF1 | KIAA0221 | NORF1 | RENT1 | pNORF1UPF1 regulator of nonsense transcripts homolog (yeast)Affinity Capture-WesternBioGRID12417715 
UPF2DKFZp434D222 | HUPF2 | KIAA1408 | MGC138834 | MGC138835 | RENT2 | smg-3UPF2 regulator of nonsense transcripts homolog (yeast)-HPRD12417715 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_RNA_DEGRADATION 5937All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE 1510All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 4829All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 179All SZGR genes in this pathway
REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 8450All SZGR genes in this pathway
REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP 177All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1 14895All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BAKKER_FOXO3_TARGETS_UP 6141All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1281751821A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-1381881951A,m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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