Gene Page: PRKDC

Summary
GeneID  5591
Symbol  PRKDC
Synonyms  DNA-PKcs|DNAPK|DNPK1|HYRC|HYRC1|XRCC7|p350
Description  protein kinase, DNA-activated, catalytic polypeptide
See related  HGNC:9413|MIM:600899|Ensembl:ENSG00000121031|HPRD:02941|
Locus tag  -
Gene type  protein-coding
Map location  8q11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0381 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LRRC240.790.74
LRFN40.750.75
COMTD10.740.68
AC006273.10.730.72
ZNF7680.730.77
FAM171A20.730.73
MACROD10.730.69
GPR172A0.730.74
MFSD100.730.74
AC009133.10.720.69
Top 10 negatively co-expressed genes
S100B-0.51-0.60
AF347015.27-0.49-0.57
C5orf53-0.49-0.55
ACOT13-0.48-0.53
PIR-0.48-0.56
COPZ2-0.47-0.54
AF347015.33-0.47-0.56
LACTB2-0.47-0.53
CSRP1-0.47-0.53
SLCO1A2-0.47-0.58
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0005515protein bindingIPI9442054 
GO:0005524ATP bindingIEA-
GO:0004677DNA-dependent protein kinase activityIDA15194694 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEABrain (GO term level: 7)-
GO:0001756somitogenesisIEA-
GO:0000723telomere maintenanceIEA-
GO:0002328pro-B cell differentiationIEA-
GO:0006303double-strand break repair via nonhomologous end joiningIEA-
GO:0006310DNA recombinationIEA-
GO:0006464protein modification processTAS7671312 
GO:0010332response to gamma radiationIEA-
GO:0007507heart developmentIEA-
GO:0006915apoptosisIEA-
GO:0018105peptidyl-serine phosphorylationIDA15194694 
GO:0033077T cell differentiation in the thymusIEA-
GO:0033153T cell receptor V(D)J recombinationIEA-
GO:0033152immunoglobulin V(D)J recombinationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP12023295 |12065431 
GO:0005958DNA-dependent protein kinase complexIDA15194694 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID9312071 
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1DNA-PKcs interacts with Akt1.BIND15678105 
AKT2PKBB | PKBBETA | PRKBB | RAC-BETAv-akt murine thymoma viral oncogene homolog 2Biochemical ActivityBioGRID16221682 
AP1B1ADTB1 | AP105A | BAM22 | CLAPB2adaptor-related protein complex 1, beta 1 subunitProtein-peptideBioGRID10608806 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorAffinity Capture-MSBioGRID15640154 
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutated-HPRD,BioGRID10464290 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetProtein-peptideBioGRID10608806 
C1DMGC12261 | MGC14659 | SUNCORnuclear DNA-binding protein-HPRD,BioGRID9679063 
CHEK1CHK1CHK1 checkpoint homolog (S. pombe)Protein-peptide
Reconstituted Complex		BioGRID10608806 |12756247 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinase-HPRD,BioGRID9632806 
CIB1CIB | KIP | KIP1 | SIP2-28calcium and integrin binding 1 (calmyrin)-HPRD,BioGRID9372844 
DCLRE1CA-SCID | DCLREC1C | FLJ11360 | FLJ36438 | RS-SCID | SCIDA | SNM1CDNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)Affinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID11955432 
E4F1E4F | MGC99614E4F transcription factor 1Protein-peptideBioGRID10608806 
EIF2S2DKFZp686L18198 | EIF2 | EIF2B | EIF2beta | MGC8508eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa-HPRD,BioGRID9442054 
HOXC4HOX3 | HOX3E | cp19homeobox C4-HPRD11279128 
HSF1HSTF1heat shock transcription factor 1in vitroBioGRID9325337 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaBiochemical ActivityBioGRID9632806 
ILF2MGC8391 | NF45 | PRO3063interleukin enhancer binding factor 2, 45kDa-HPRD,BioGRID9442054 
ILF3CBTF | DRBF | DRBP76 | MMP4 | MPHOSPH4 | MPP4 | NF-AT-90 | NF110 | NF90 | NFAR | NFAR-1 | NFAR2 | TCP110 | TCP80interleukin enhancer binding factor 3, 90kDa-HPRD,BioGRID9442054 
KAT2AGCN5 | GCN5L2 | MGC102791 | PCAF-b | hGCN5K(lysine) acetyltransferase 2ABiochemical ActivityBioGRID9488450 
LIG4-ligase IV, DNA, ATP-dependentProtein-peptideBioGRID10608806 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID9748231 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8-HPRD,BioGRID11749722 
MAPK9JNK-55 | JNK2 | JNK2A | JNK2ALPHA | JNK2B | JNK2BETA | PRKM9 | SAPK | p54a | p54aSAPKmitogen-activated protein kinase 9Biochemical ActivityBioGRID11749722 
MRE11AATLD | HNGS1 | MRE11 | MRE11BMRE11 meiotic recombination 11 homolog A (S. cerevisiae)Protein-peptideBioGRID10608806 
NBNAT-V1 | AT-V2 | ATV | FLJ10155 | MGC87362 | NBS | NBS1 | P95nibrinNBS1 interacts with PRKDC (DNA-PKc).BIND15758953 
NCF1FLJ79451 | NCF1A | NOXO2 | SH3PXD1A | p47phoxneutrophil cytosolic factor 1Biochemical ActivityBioGRID9914162 
NCF2FLJ93058 | NCF-2 | NOXA2 | P67-PHOX | P67PHOXneutrophil cytosolic factor 2Biochemical ActivityBioGRID9914162 
NCF4MGC3810 | NCF | P40PHOX | SH3PXD4neutrophil cytosolic factor 4, 40kDaBiochemical ActivityBioGRID9914162 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6Affinity Capture-MS
Biochemical Activity		BioGRID10823961 
PARP1ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1poly (ADP-ribose) polymerase 1-HPRD9398855 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID12171929 
PRKDC is a PCNA-binding proteinBIND12171929 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, delta-HPRD9774685 
PTSFLJ97081 | PTPS6-pyruvoyltetrahydropterin synthaseProtein-peptideBioGRID10608806 
RAD17CCYC | FLJ41520 | HRAD17 | R24L | RAD17SP | RAD24RAD17 homolog (S. pombe)Protein-peptideBioGRID10608806 
RBBP8CTIP | RIMretinoblastoma binding protein 8Protein-peptideBioGRID10608806 
RPA1HSSB | REPA1 | RF-A | RP-A | RPA70replication protein A1, 70kDa-HPRD,BioGRID10064605 
RPA2REPA2 | RPA32replication protein A2, 32kDaDNA-PKcs interacts with RPA2.BIND11000264 
-HPRD,BioGRID10064605 |11731442 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD10470151 
Biochemical Activity
Protein-peptide		BioGRID9679063 |10608806 
|12756247 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD14743216 
WRNDKFZp686C2056 | RECQ3 | RECQL2 | RECQL3Werner syndrome-HPRD,BioGRID11889123 
XRCC4-X-ray repair complementing defective repair in Chinese hamster cells 4-HPRD9430729 
XRCC5FLJ39089 | KARP-1 | KARP1 | KU80 | KUB2 | Ku86 | NFIVX-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)-HPRD10207052 |10446239 
XRCC5 (Ku80) interacts with PRKDC (DNA-PKc).BIND15758953 
Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex		BioGRID9312071 |10446239 
|12393188 
XRCC6CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAAX-ray repair complementing defective repair in Chinese hamster cells 6-HPRD9312071 |10446239 
|11279128 
Affinity Capture-Western
in vitro
in vivo		BioGRID10064605 |10446239 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NON_HOMOLOGOUS_END_JOINING 148All SZGR genes in this pathway
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
BIOCARTA_G2_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_FAS_PATHWAY 3022All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_TNFR1_PATHWAY 2921All SZGR genes in this pathway
PID_DNA_PK_PATHWAY 1610All SZGR genes in this pathway
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PID_PI3KCI_AKT_PATHWAY 3530All SZGR genes in this pathway
PID_BARD1_PATHWAY 2919All SZGR genes in this pathway
REACTOME_DOUBLE_STRAND_BREAK_REPAIR 2414All SZGR genes in this pathway
REACTOME_DNA_REPAIR 11259All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_DN 6642All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_UP 13378All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 11785All SZGR genes in this pathway
MISSIAGLIA_REGULATED_BY_METHYLATION_DN 12267All SZGR genes in this pathway
WAKASUGI_HAVE_ZNF143_BINDING_SITES 5833All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_2 3317All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
REN_BOUND_BY_E2F 6140All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_SUBGROUPS 3020All SZGR genes in this pathway
MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_DN 7345All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN 172107All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_DN 8049All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
DING_LUNG_CANCER_BY_MUTATION_RATE 2018All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G123_UP 4521All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
WIERENGA_PML_INTERACTOME 4223All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
ABRAMSON_INTERACT_WITH_AIRE 4533All SZGR genes in this pathway


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