Gene Page: PARD3

Summary
GeneID  56288
Symbol  PARD3
Synonyms  ASIP|Baz|Bazooka|FLJ21015|PAR3|PAR3alpha|PARD3A|SE2-5L16|SE2-5LT1|SE2-5T2
Description  par-3 partitioning defective 3 homolog (C. elegans)
See related  HGNC:16051|MIM:606745|Ensembl:ENSG00000148498|HPRD:05994|
Locus tag  RP11-406D17.1
Gene type  protein-coding
Map location  10p11.22-p11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.991 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007409axonogenesisTASneuron, axon, neurite (GO term level: 12)14676191 
GO:0007205activation of protein kinase C activityTAS11260256 
GO:0006461protein complex assemblyTAS10934474 
GO:0007163establishment or maintenance of cell polarityTAS14676191 
GO:0008356asymmetric cell divisionTAS10934474 
GO:0007049cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005923tight junctionIDABrain (GO term level: 10)14676191 
GO:0005923tight junctionISSBrain (GO term level: 10)-
GO:0012505endomembrane systemIEA-
GO:0005819spindleIEA-
GO:0005737cytoplasmIEA-
GO:0005938cell cortexIEA-
GO:0005913cell-cell adherens junctionIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD10934474 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD14760703 
ECT2FLJ10461 | MGC138291epithelial cell transforming sequence 2 oncogeneAffinity Capture-WesternBioGRID15254234 
F11RCD321 | JAM | JAM-1 | JAM-A | JAM1 | JAMA | JCAM | KAT | PAM-1F11 receptor-HPRD11447115 
Reconstituted ComplexBioGRID12953056 
JAM2C21orf43 | CD322 | JAM-B | JAMB | PRO245 | VE-JAM | VEJAMjunctional adhesion molecule 2Affinity Capture-Western
Reconstituted Complex		BioGRID12953056 
JAM3FLJ14529 | JAM-C | JAMCjunctional adhesion molecule 3Affinity Capture-Western
Reconstituted Complex		BioGRID12953056 
PARD6APAR-6A | PAR6 | PAR6C | PAR6alpha | TAX40 | TIP-40par-6 partitioning defective 6 homolog alpha (C. elegans)Affinity Capture-WesternBioGRID12459187 
PARD6BPAR6Bpar-6 partitioning defective 6 homolog beta (C. elegans)Affinity Capture-WesternBioGRID12459187 
PARD6GFLJ45701 | PAR-6G | PAR6gammapar-6 partitioning defective 6 homolog gamma (C. elegans)Affinity Capture-WesternBioGRID12459187 
PLCB1FLJ45792 | PI-PLC | PLC-154 | PLC-I | PLC154phospholipase C, beta 1 (phosphoinositide-specific)PLCB1 (PLC-beta-1) interacts with PARD3 (Par3). This interaction was modeled on a demonstrated interaction between rat PLCB1 and human Par3.BIND15782111 
PLCB3FLJ37084phospholipase C, beta 3 (phosphatidylinositol-specific)PLCB3 (PLC-beta-3) interacts with PARD3 (Par3).BIND15782111 
PRKCIDXS1179E | MGC26534 | PKCI | nPKC-iotaprotein kinase C, iotaAffinity Capture-Western
Reconstituted Complex		BioGRID12459187 
PRKCZPKC-ZETA | PKC2protein kinase C, zetaAffinity Capture-WesternBioGRID12459187 
PVRL3CD113 | CDw113 | DKFZp566B0846 | FLJ90624 | PPR3 | PRR3 | PVRR3 | nectin-3poliovirus receptor-related 3Affinity Capture-Western
Reconstituted Complex		BioGRID12515806 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD12650946 
SMAD7CRCS3 | FLJ16482 | MADH7 | MADH8SMAD family member 7-HPRD12650946 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideAffinity Capture-MSBioGRID17353931 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideAffinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 5141All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION 167All SZGR genes in this pathway
REACTOME_CELL_CELL_JUNCTION_ORGANIZATION 5631All SZGR genes in this pathway
REACTOME_TIGHT_JUNCTION_INTERACTIONS 2911All SZGR genes in this pathway
REACTOME_CELL_JUNCTION_ORGANIZATION 7843All SZGR genes in this pathway
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 6342All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
MIDORIKAWA_AMPLIFIED_IN_LIVER_CANCER 5538All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_DN 2518All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
MCCOLLUM_GELDANAMYCIN_RESISTANCE_DN 76All SZGR genes in this pathway
AMBROSINI_FLAVOPIRIDOL_TREATMENT_TP53 10963All SZGR genes in this pathway
WANG_RECURRENT_LIVER_CANCER_UP 2013All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway


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